Induced Pluripotent Stem-Cell-Derived Neural Cell Types in Treatment of Stroke

Lau, Vivian W; Platt, Simon; Stice, Steven L.; West, Franklin D.

doi:10.1007/978-3-319-15063-5_10

Cited by 2 publications

(6 citation statements)

References 132 publications

(186 reference statements)

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“…Multifunctional therapeutic action of transplanted neural stem cells. Transplanted NSCs derived from ESCs, iPSCs, or fetal brain have demonstrated multimodal therapeutic function after intravenous, intraparenchymal, or intracerebroventricular administration (Kokaia et al, ; Lau et al, ). NSCs demonstrate immunomodulatory function through the expression of cytokines and chemokines in response pro‐inflammatory signaling from activated microglia and infiltrating circulatory immune cells (Huang et al, ; Watanabe et al, ).…”

Section: Sources Of Neural Stem Cellsmentioning

confidence: 99%

“…iPSC‐NSC‐treated stroke pigs ultimately demonstrated faster recovery of functional deficits relative to nontreated control stroke pigs (Lau, Platt, Grace, Baker, & West, ). Although further progress is needed for clinical application of iPSC technology for stroke, with shortened reprogramming duration being critical, these preclinical studies show that iPSC‐NSCs are a promising future treatment option for stroke (Lau, Platt, Stice, & West, ).…”

Section: Sources Of Neural Stem Cellsmentioning

confidence: 99%

“…In preclinical animal models of stroke, IP injections are the most commonly reported and are performed through a transcranial approach (Table ). The popularity of IP transplantation is likely due to the numerous advantages of direct transplantation including site specificity, eliminating the need for cells to transverse the BBB, guaranteed delivery of large cell numbers to the injury site, and limiting the potential for off‐target effects (e.g., clogging microvasculature in nontarget organs leading to ischemic events; Lau et al, ). The most significant hurdle to the clinical use of IP transplantation is the highly invasive nature of the required craniectomy, which could lead to additional complications in stroke patients that are already severely compromised.…”

Section: Clinical Considerations For Translationmentioning

confidence: 99%

“…Since the in vitro characterization of iPSC-NSCs, several studies have documented improved tissue and functional recovery after transplantation into preclinical rodent and pig stroke models (Oki et al, 2012;Polentes et al, 2012; iPSC-NSC-treated stroke pigs ultimately demonstrated faster recovery of functional deficits relative to nontreated control stroke pigs (Lau, Platt, Grace, Baker, & West, 2018). Although further progress is needed for clinical application of iPSC technology for stroke, with shortened reprogramming duration being critical, these preclinical studies show that iPSC-NSCs are a promising future treatment option for stroke (Lau, Platt, Stice, & West, 2015).…”

Section: Induced Pluripotent Stem Cell-derived Neural Stem Cellsmentioning

confidence: 99%

“…IV administration of NSCs is another popular route since it is generally the least invasive and is less technically challenging (Lau et al, ). Indeed, IV administration could potentially allow NSCs to be injected during the acute stage of stroke when patients may be too unstable to undergo transcranial IP NSC treatment, or enable NSCs to be administered by healthcare professionals that are not capable of performing a craniotomy.…”

Section: Clinical Considerations For Translationmentioning

confidence: 99%

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Neural stem cell therapy for stroke: A multimechanistic approach to restoring neurological function

2019

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Introduction Neural stem cells (NSCs) have demonstrated multimodal therapeutic function for stroke, which is the leading cause of long‐term disability and the second leading cause of death worldwide. In preclinical stroke models, NSCs have been shown to modulate inflammation, foster neuroplasticity and neural reorganization, promote angiogenesis, and act as a cellular replacement by differentiating into mature neural cell types. However, there are several key technical questions to address before NSC therapy can be applied to the clinical setting on a large scale. Purpose of Review In this review, we will discuss the various sources of NSCs, their therapeutic modes of action to enhance stroke recovery, and considerations for the clinical translation of NSC therapies. Understanding the key factors involved in NSC‐mediated tissue recovery and addressing the current translational barriers may lead to clinical success of NSC therapy and a first‐in‐class restorative therapy for stroke patients.

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Section: Sources Of Neural Stem Cellsmentioning

confidence: 99%

Section: Sources Of Neural Stem Cellsmentioning

confidence: 99%

Section: Clinical Considerations For Translationmentioning

confidence: 99%

Section: Induced Pluripotent Stem Cell-derived Neural Stem Cellsmentioning

confidence: 99%

Section: Clinical Considerations For Translationmentioning

confidence: 99%

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Neural stem cell therapy for stroke: A multimechanistic approach to restoring neurological function

2019

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Review article: Paracrine effects of Transplanted Neural stem cells in Ischemic strokes

Methaq Mueen Al-Kaabi,

Abdal-jabbar Falih AL-Rubai

2021

IJCMG

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Ischemic stroke is one of the most common causes of death in the world. Pathophysiologically, ischemic stroke is associated with blood brain barrier disruption, cell loss, inflammation and intense immune reaction which worsen the condition. The Stroke Treatment Academic Industry Roundtable recommends the use of any treatment that has multiple mechanisms of action to restore the neurological function. Growing evidences from researchers to understand the biology of neural stem cells indicated that these cells have crucial role in brain homeostasis and have high therapeutic potential to modify and restore neurological function after neurovascular injury. Contemporarily, Paracrine hypothesis is growing and indicated that neural stem cells transplantation can release several neurotrophic factors which can regenerate, restore, and modulate the neurological diseases by mitigating the inflammatory process, reducing the immune reactions and also can stimulate the angiogenesis and neurogenesis. This, generate a new attitude toward the development of acellular therapy instead of using whole allogenic neural stem cells in the regenerative medicine. This review is to focus on the paracrine effects of transplanted neural stem cells in the brain ischemic injuries which can modulate and improve the neurological outcome after ischemic injury.

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Induced Pluripotent Stem-Cell-Derived Neural Cell Types in Treatment of Stroke

Cited by 2 publications

References 132 publications

Neural stem cell therapy for stroke: A multimechanistic approach to restoring neurological function

Neural stem cell therapy for stroke: A multimechanistic approach to restoring neurological function

Review article: Paracrine effects of Transplanted Neural stem cells in Ischemic strokes

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