Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity

Sarvestani, Samaneh K.; Signs, Steven A.; Hu, Bo; Yeu, Yunku; Feng, Hao; Ni, Ying; Hill, David R.; Fisher, Robert C.; Ferrandon, Sylvain; DeHaan, Reece K.; Stiene, Jennifer; Cruise, Michael; Hwang, Tae Hyun; Shen, Xiling; Spence, Jason R.; Huang, Emina H.

doi:10.1038/s41467-020-20351-5

Cited by 66 publications

(54 citation statements)

References 111 publications

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“…By adding growth factors for the growth and development of different organs based on the intestinal organ culture system, other organs derived from the digestive tract epithelium, such as the liver[ 47 ] and pancreas[ 53 ], have been established, in addition to other epithelial organs from non-digestive tract sources, such as the prostate[ 54 ] and breast[ 55 ]. Intestinal organs can simulate the relationship between cells in vivo and can be used to study the characteristics of stem cells; they are also widely used in studying ulcerative colitis (UC)[ 56 ] and other intestinal diseases.…”

Section: Bioprinting Organoids Applicationsmentioning

confidence: 99%

Developments and Opportunities for 3D Bioprinted Organoids

Ren¹,

Yang²,

Ma³

et al. 2024

IJB

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Organoids developed from pluripotent stem cells or adult stem cells are three-dimensional cell cultures possessing certain key characteristics of their organ counterparts, and they can mimic certain biological developmental processes of organs in vitro. Therefore, they have promising applications in drug screening, disease modeling, and regenerative repair of tissues and organs. However, the construction of organoids currently faces numerous challenges, such as breakthroughs in scale size, vascularization, better reproducibility, and precise architecture in time and space. Recently, the application of bioprinting has accelerated the process of organoid construction. In this review, we present current bioprinting techniques and the application of bioinks and summarize examples of successful organoid bioprinting. In the future, a multidisciplinary combination of developmental biology, disease pathology, cell biology, and materials science will aid in overcoming the obstacles pertaining to the bioprinting of organoids. The combination of bioprinting and organoids with a focus on structure and function can facilitate further development of real organs.

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Section: Bioprinting Organoids Applicationsmentioning

confidence: 99%

Developments and Opportunities for 3D Bioprinted Organoids

Ren¹,

Yang²,

Ma³

et al. 2024

IJB

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show abstract

“…The limitations are common to organoid modelling, including lack of vasculature and immune cells, high cost, technical difficulties and the closed nature of the 3D structure. Chip technology, microfluidics and co-culturing systems could address some of these limitations 24 , 25 . However, collectively, the cellular and mouse models developed in the past decade provide a long-awaited milestone that should stimulate translational and preclinical research in coeliac disease.…”

Section: Milestones and Gaps In Pathogenesismentioning

confidence: 99%

Society for the Study of Celiac Disease position statement on gaps and opportunities in coeliac disease

Sánchez

Silvester

Lebwohl

et al. 2021

Nat Rev Gastroenterol Hepatol

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Progress has been made in understanding coeliac disease, a relatively frequent and underappreciated immune-mediated condition that occurs in genetically predisposed individuals. However, several gaps remain in knowledge related to diagnosis and management. The gluten-free diet, currently the only available management, is not curative or universally effective (some adherent patients have ongoing duodenal injury). Unprecedented numbers of emerging therapies, including some with novel tolerogenic mechanisms, are currently being investigated in clinical trials. In March 2020, the Celiac Disease Foundation and the Society for the Study of Celiac Disease convened a consensus workshop to identify high-yield areas of research that should be prioritized. Workshop participants included leading experts in clinical practice, academia, government and pharmaceutical development, as well as representatives from patient support groups in North America. This Roadmap summarizes key advances in the field of coeliac disease and provides information on important discussions from the consensus approach to address gaps and opportunities related to the pathogenesis, diagnosis and management of coeliac disease. The morbidity of coeliac disease is often underestimated, which has led to an unmet need to improve the management of these patients. Expanded research funding is needed as coeliac disease is a potentially curable disease.

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“…The authors further showed an example of how this system can be used to study motility disorders of the human gastrointestinal tract. Interestingly a recent study demonstrated that patient-derived (UC) organoids recapitulated colitic reactivity offering opportunities to tailor interventions to the individual patient [146]. In this context, a recent study demonstrated that PSC-derived intestinal organoids can be used for compound testing [147].…”

Section: Intestinal Organoidsmentioning

confidence: 99%

The Gut-Brain Axis in Inflammatory Bowel Disease—Current and Future Perspectives

Günther

Rothhammer

Karow

et al. 2021

IJMS

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The gut–brain axis is a bidirectional communication system driven by neural, hormonal, metabolic, immunological, and microbial signals. Signaling events from the gut can modulate brain function and recent evidence suggests that the gut–brain axis may play a pivotal role in linking gastrointestinal and neurological diseases. Accordingly, accumulating evidence has suggested a link between inflammatory bowel diseases (IBDs) and neurodegenerative, as well as neuroinflammatory diseases. In this context, clinical, epidemiological and experimental data have demonstrated that IBD predisposes a person to pathologies of the central nervous system (CNS). Likewise, a number of neurological disorders are associated with changes in the intestinal environment, which are indicative for disease-mediated gut–brain inter-organ communication. Although this axis was identified more than 20 years ago, the sequence of events and underlying molecular mechanisms are poorly defined. The emergence of precision medicine has uncovered the need to take into account non-intestinal symptoms in the context of IBD that could offer the opportunity to tailor therapies to individual patients. The aim of this review is to highlight recent findings supporting the clinical and biological link between the gut and brain, as well as its clinical significance for IBD as well as neurodegeneration and neuroinflammation. Finally, we focus on novel human-specific preclinical models that will help uncover disease mechanisms to better understand and modulate the function of this complex system.

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Induced organoids derived from patients with ulcerative colitis recapitulate colitic reactivity

Cited by 66 publications

References 111 publications

Developments and Opportunities for 3D Bioprinted Organoids

Developments and Opportunities for 3D Bioprinted Organoids

Society for the Study of Celiac Disease position statement on gaps and opportunities in coeliac disease

The Gut-Brain Axis in Inflammatory Bowel Disease—Current and Future Perspectives

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