Induced hypothermia using large volume, ice-cold intravenous fluid in comatose survivors of out-of-hospital cardiac arrest:

Bernard, Stephen; Buist, Michael; Monteiro, Orlando; Smith, Karen

doi:10.1016/s0300-9572(02)00276-9

Cited by 440 publications

(241 citation statements)

References 13 publications

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“…For example, the immediate use of ice-cold intravenous saline to induce TH has been shown to be feasible and can achieve target temperatures (32-34°C) within 60 min. 23,24 It is possible that the use of newer devices and adjunctive use of cold saline might allow for partial cooling to be achieved in an even shorter time frame. In addition, while a number of groups have demonstrated the value of the mouse model of cardiac arrest to evaluate post-resuscitation injury, 25-27 further work in larger animal models will be required.…”

Section: Discussionmentioning

confidence: 99%

Intra-arrest cooling with delayed reperfusion yields higher survival than earlier normothermic resuscitation in a mouse model of cardiac arrest

Zhao¹,

Abella²,

Beiser³

et al. 2008

Resuscitation

103

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SummaryBackground-Therapeutic hypothermia (TH) represents an important method to attenuate postresuscitation injury after cardiac arrest. Laboratory investigations have suggested that induction of hypothermia before return of spontaneous circulation (ROSC) may confer the greatest benefit. We hypothesized that a short delay in resuscitation to induce hypothermia before ROSC, even at the expense of more prolonged ischemia, may yield both physiological and survival advantages.

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Section: Discussionmentioning

confidence: 99%

Intra-arrest cooling with delayed reperfusion yields higher survival than earlier normothermic resuscitation in a mouse model of cardiac arrest

Zhao¹,

Abella²,

Beiser³

et al. 2008

Resuscitation

103

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“…Intravascular cooling bypasses the peripheral compartment and can achieve cooling of the core in a smaller amount of time. The use of intravenous ice-cold fluids in patients resuscitated from cardiac arrest as a rapid, safe, and easy means of inducing hypothermia is supported by several studies [79][80][81]. One study used 4°C Lactated Ringer's solution infused for 30 min in 22 resuscitated cardiac arrest patients and showed a decrease in median T c of 1.7°C, as well as beneficial hemodynamic, renal, and acid-base effects [80].…”

Section: Infusion Of Ice-cold Fluidsmentioning

confidence: 99%

“…The use of intravenous ice-cold fluids in patients resuscitated from cardiac arrest as a rapid, safe, and easy means of inducing hypothermia is supported by several studies [79][80][81]. One study used 4°C Lactated Ringer's solution infused for 30 min in 22 resuscitated cardiac arrest patients and showed a decrease in median T c of 1.7°C, as well as beneficial hemodynamic, renal, and acid-base effects [80]. Infusing up to 30 ml/kg ice-cold 4°C saline has been shown to effectively and quickly lower T c by 4.0±0.3°C within 60 minutes when used in combination with surface cooling [79].…”

Section: Infusion Of Ice-cold Fluidsmentioning

confidence: 99%

Therapeutic Hypothermia for Acute Neurological Injuries

2012

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Therapeutic hypothermia (TH) is the intentional reduction of core body temperature to 32°C to 35°C, and is increasingly applied by intensivists for a variety of acute neurological injuries to achieve neuroprotection and reduction of elevated intracranial pressure. TH improves outcomes in comatose patients after a cardiac arrest with a shockable rhythm, but other off-label applications exist and are likely to increase in the future. This comprehensive review summarizes the physiology and cellular mechanism of action of TH, as well as different means of TH induction and maintenance with potential side effects. Indications of TH are critically reviewed by disease entity, as reported in the most recent literature, and evidence-based recommendations are provided.

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“…Multiple techniques of hypothermia induction have been published including: application of ice packs; 5 surface cooling with cooled forced-air, 4,20 or circulating water blankets; 18,19 infusion of 4°C iv fluids; [26][27][28] immersion in cold water; 29 specialized endovascular cooling devices; 21,30,31 and cardiopulmonary bypass. 32 No trials comparing hypothermia techniques in cardiac arrest patients have been published.…”

mentioning

confidence: 99%

“…27 A retrospective review found endovascular cooling was superior to cooling blankets for rapid induction of hypothermia in subarachnoid hemorrhage patients. 28 At present, there is insufficient evidence to make definitive recommendations among techniques to induce therapeutic hypothermia after cardiac arrest. Comparative studies of techniques or combinations of techniques are required.…”

mentioning

confidence: 99%

Management following resuscitation from cardiac arrest: Recommendations from the 2003 Rocky mountain critical care conference

Bell

Brindley

Forrest

et al. 2005

Can J Anesth/J Can Anesth

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P Pu ur rp po os se e: : To propose a strategy for the management of patients admitted to critical care units after resuscitation from cardiac arrest.S So ou ur rc ce e: : Prior to the conference relevant studies were identified via literature searches and brief reviews circulated on the following topics: glucose and blood pressure management; therapeutic hypothermia; prearrest outcome prediction; post-arrest outcome prediction; and management of myocardial ischemia. Two days were devoted to assessing evidence and developing a management strategy at the conference. Consensus opinion of conference participants [intensive care unit (ICU) physicians] was used when high grade evidence was unavailable. Additional literature searches and data grading were performed post-conference. P Pr ri in nc ci ip pa al l f fi in nd di in ng gs s: : High grade evidence was lacking in most areas. Specific goals of treatment were proposed for: general care; neurologic care; respiratory care; cardiac care; and gastrointestinal care. There was adequate evidence to recommend therapeutic hypothermia for comatose patients who had witnessed ventricular fibrillation or ventricular tachycardia arrests. Conference participants supported extending therapeutic hypothermia to other presenting rhythms in selected circumstances. Additional goals included mean arterial pressure 80 to 100 mmHg, glucose 5 to 8 mmol·L -1 using insulin infusions, and PaO 2 > 100 mmHg for the first 24 hr. Absent withdrawal to pain 72 hr after resuscitation should prompt consideration of palliative care. The level of evidence for other recommendations was low.C Co on nc cl lu us si io on ns s: : The proposed management strategy represents an approach to manage patients in the ICU following resuscitation from cardiac arrest. Most of the recommendations are based on low grade evidence. Additional research is needed to improve the evidence base. A standard post-arrest management strategy could help facilitate future research. Objectif : Proposer une stratégie de traitement à adopter avec les patients admis aux unités de soins intensifs (USI) après la réanimation post-arrêt cardiaque. Source : Avant la conférence, les études utiles ont été repérées dans les publications et de brèves revues ont circulé sur

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Induced hypothermia using large volume, ice-cold intravenous fluid in comatose survivors of out-of-hospital cardiac arrest:

Cited by 440 publications

References 13 publications

Intra-arrest cooling with delayed reperfusion yields higher survival than earlier normothermic resuscitation in a mouse model of cardiac arrest

Intra-arrest cooling with delayed reperfusion yields higher survival than earlier normothermic resuscitation in a mouse model of cardiac arrest

Therapeutic Hypothermia for Acute Neurological Injuries

Management following resuscitation from cardiac arrest: Recommendations from the 2003 Rocky mountain critical care conference

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