Induced Hypothermia in Severe Bacterial Meningitis

Respective impact of lowering body temperature and heart rate on mortality in septic shock: mediation analysis of a randomized trial

“…Of note, only three patients with meningitis were included in our study. In such patients it has been suggested that fever may have a different impact on outcome and that therapeutic hypothermia appeared harmful [11,39,40]. Our results on the mediation of heart rate and temperature lowering on outcomes cannot be extrapolated to the late mortality of septic shock and to febrile ICU patients without severe infection.…”

Reducing Mortality in Critically Ill Patients: A Systematic Update

“…Mourvillier et al conducted an unblinded mRCT in 49 French ICUs to assess the effect of moderate hypothermia on neurological outcome in patients affected by severe bacterial meningitis [ 7 ]. The primary outcome was 3-month score on the Glasgow Outcome Scale (GOS).…”

“…Only four mRCTs that fulfi ll our inclusion criteria were found. One intervention, hypothermia in bacterial meningitis [ 7 ], increased mortality. Three interventionscolloids [ 8 ], vasopressin and steroids in cardiocirculatory arrest (CCA) [ 9 ], and ulinastatin in severe sepsis [ 10 ] -seem to have a benefi cial effect on survival.…”

Understanding coma in bacterial meningitis

“…Such comatose state at presentation is a strong indicator of poor outcome [1][2][3]. At disease onset, bacterial invasion and the release of bacterial compounds promote inflammation, leukocyte invasion and stimulation of microglia.…”