Induced Gene Unstabilization

Zamenhof, Stephen; Giovanni, Rosalie De; Greer, Sheldon

doi:10.1038/181827a0

Cited by 112 publications

(39 citation statements)

References 14 publications

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“…In fact, it is possible to enhance the damage to tumor cells by incorporating radiosensitising drugs to the gene sequence through chemotherapy. Since halopyrimidines are found among the chemicals with potential radiosensitising activity [109,110], we have recently addressed 2-chloro, 2-bromo, and 5-bromopyrimidine [111], and uracil (U), 5-fluorouracil (FU) and 5-chlorouracil (ClU) in a scattering study [57] (results for 5-bromouracil and 5-iodouracil [112] are not shown here). The use of pseudopotentials in combination with parallel processing is particularly important for these systems.…”

Section: Elastic Scattering: Single Open Channelmentioning

confidence: 99%

Recent advances in the application of the Schwinger multichannel method with pseudopotentials to electron-molecule collisions

et al. 2015

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Abstract. The Schwinger multichannel method [K. V. McKoy, Phys. Rev. A 30, 1734 (1984)], which is based on the Schwinger variational principle for the scattering amplitude [J. Schwinger, Phys. Rev. 72, 742 (1947)], was designed to account for exchange, polarization and electronically multichannel coupling effects in the low-energy region of electron scattering from molecules with arbitrary geometry. The applications of the method became more ambitious with the availability of computer power combined with parallel processing, use of norm-conserving pseudopotentials and improvement of the description of target excited states (minimal orbital basis for single configuration interaction). The most recent applications involving 33 and 45 electronically open channels for phenol and ethylene molecules, represent good examples of the present status of the method. In this colloquium, we review the strategy and point out new directions to apply the method in its full extension.

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Section: Elastic Scattering: Single Open Channelmentioning

confidence: 99%

Recent advances in the application of the Schwinger multichannel method with pseudopotentials to electron-molecule collisions

et al. 2015

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“…This is extremely important with regard to the sensitivity of halouracils to ionizing radiation, in particular for hadrontherapy treatments by carbon ions. Effectively, early studies have shown that DNA damage is strongly enhanced when replacing thymine by 5-bromouracil [31]. Such radio-sensitivity has also been identified more generally for 5-halouracil molecules and is widely used in radiation therapy treatments [32].…”

Section: −16mentioning

confidence: 99%

Non-adiabatic interactions in charge transfer collisions

Bacchus‐Montabonel¹,

Rozsályi²,

Bene³

et al. 2013

Open Physics

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Abstract:An analysis of the charge transfer mechanism in the collision of multiply charged ions with molecular and biomolecular targets is performed, considering the non-adiabatic interactions between the molecular states involved. Collisions of doubly charged C 2+ ions on small molecular targets, C O and OH, have been investigated, together with the analysis of charge transfer between C 4+ ions on uracil and halouracil biomolecular targets. The process is studied theoretically by means of ab-initio molecular calculations followed by a semi-classical treatment of the collision dynamics. The influence of rotational couplings is discussed with regard to the collision energy. Strong anisotropic and vibration effects are pointed out. PACS

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“…of 0-85 % NaCl. The highlypolymerized DNA was isolated from the cells by the method of Zamenhof, Reiner, De Giovanni & Rich (1956). A micromodification of the Dische diphenylamine test was used to estimate the amount of DNA obtained (Zamenhof, 1957).…”

Section: (Received 14 September 1962)mentioning

confidence: 99%