2002
DOI: 10.1128/mcb.22.11.3744-3756.2002
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Induced Expression and Association of the Mona/Gads Adapter and Gab3 Scaffolding Protein during Monocyte/Macrophage Differentiation

Abstract: Mona/Gads is a Grb2-related, Src homology 3 (SH3) and SH2 domain-containing adapter protein whose expression is restricted to cells of hematopoietic lineage (i.e., monocytes and T lymphocytes). During monocyte/ macrophage differentiation, Mona is induced and interacts with the macrophage colony-stimulating factor receptor, M-CSFR (also called Fms), suggesting that Mona could be involved in developmental signaling downstream of the M-CSFR by recruiting additional signaling proteins to the activated receptor. Ou… Show more

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Cited by 37 publications
(40 citation statements)
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References 60 publications
(119 reference statements)
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“…28 While HPK1-N cells already react to M-CSF stimulation (Figure 2d) and express the M-CSFR (Figure 3c), M-CSFR triggered pathways may function inefficiently. 20,29,30 Caspase cleavage of HPK1 was shown to modulate its function in lymphocytes. 8,14 In contrast, little is known about the role of HPK1 in myeloid cells.…”
Section: Discussionmentioning
confidence: 99%
“…28 While HPK1-N cells already react to M-CSF stimulation (Figure 2d) and express the M-CSFR (Figure 3c), M-CSFR triggered pathways may function inefficiently. 20,29,30 Caspase cleavage of HPK1 was shown to modulate its function in lymphocytes. 8,14 In contrast, little is known about the role of HPK1 in myeloid cells.…”
Section: Discussionmentioning
confidence: 99%
“…However, only the late wave, which is independent of Grb2/Sos assembly or PI 3-kinase activity, is required for macrophage differentiation (Gobert Gosse et al 2005). Mona, an adaptor protein that increases late Erk1/2 phosphorylation (Bourgin et al 2002) and Gab3 are coinduced during monocytic differentiation in a CSF-1R Tyr-807-dependent manner (Fig. 4A).…”
Section: Er Stanley and V Chitumentioning
confidence: 99%
“…Mona interacts with Gab3 and with the CSF-1R pTyr-697 site. This site is also important for Gab3 tyrosine phosphorylation, induction of Mona expression, and macrophage differentiation (Bourgin et al 2002). Gab proteins interact with Shp2 and mediate Erk1/2 activation downstream from growth factor receptors (Nishida et al 1999;Meng et al 2005;Lee et al 2011).…”
Section: Er Stanley and V Chitumentioning
confidence: 99%
“…8,26 Thus, addition of the MEK inhibitor U0126 could be delayed by 24 h after the beginning of M-CSF stimulation while being still able to block M-CSF differentiation signal. 8 This prompted us to perform delayed PP2 addition experiments on M-CSF stimulation of FD-Fms cells.…”
Section: Macrophage Differentiation Requires Late and Sustained Sfk Amentioning
confidence: 99%
“…Flow cytometry determination of Mac-2 expression on FD-Fms cells was performed by indirect immunofluorescence as previously described. 26 Mac2 antibody and FITC-conjugated F(ab 0 ) 2 fragment goat anti-rat immunoglobulin G were from Cedarlane and Caltag Laboratories (Burlingame, CA, USA), respectively. Cultivated BMMC were labeled by direct immunofluorescence according to instructions from antibody manufacturers.…”
Section: Morphological and Flow Cytometric Analysesmentioning
confidence: 99%