Induced ER Chaperones Regulate a Receptor-like Kinase to Mediate Antiviral Innate Immune Response in Plants

Caplan, Jeffrey; Zhu, Xiaoxian; Mamillapalli, Padmavathi; Marathe, Rajendra; Anandalakshmi, R.; Dinesh-Kumar, S. P.

doi:10.1016/j.chom.2009.10.005

Cited by 89 publications

(72 citation statements)

References 58 publications

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“…However, virus-induced gene silencing (VIGS) of two PDI family members in tobacco, NtERp57 and NtP5, partially decreased N-gene mediated resistance to tobacco mosaic virus (TMV) (29). Whereas this hinted at an interaction between plant PDIs and viruses, it did not indicate a role as a susceptibility factor.…”

Section: Hvpdil5-1 Is a Susceptibility Factor To Bymoviruses In Barlementioning

confidence: 92%

PROTEIN DISULFIDE ISOMERASE LIKE 5-1is a susceptibility factor to plant viruses

Yang

Lüpken

Habekuß

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Protein disulfide isomerases (PDIs) catalyze the correct folding of proteins and prevent the aggregation of unfolded or partially folded precursors. Whereas suppression of members of the PDI gene family can delay replication of several human and animal viruses (e.g., HIV), their role in interactions with plant viruses is largely unknown. Here, using a positional cloning strategy we identified variants of PROTEIN DISULFIDE ISOMERASE LIKE 5-1 (HvPDIL5-1) as the cause of naturally occurring resistance to multiple strains of Bymoviruses. The role of wild-type HvPDIL5-1 in conferring susceptibility was confirmed by targeting induced local lesions in genomes for induced mutant alleles, transgene-induced complementation, and allelism tests using different natural resistance alleles. The geographical distribution of natural genetic variants of HvPDIL5-1 revealed the origin of resistance conferring alleles in domesticated barley in Eastern Asia. Higher sequence diversity was correlated with areas with increased pathogen diversity suggesting adaptive selection for bymovirus resistance. HvPDIL5-1 homologs are highly conserved across species of the plant and animal kingdoms implying that orthologs of HvPDIL5-1 or other closely related members of the PDI gene family may be potential susceptibility factors to viruses in other eukaryotic species.allele mining | resistance breeding | soil-borne virus disease | chaperone

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Section: Hvpdil5-1 Is a Susceptibility Factor To Bymoviruses In Barlementioning

confidence: 92%

PROTEIN DISULFIDE ISOMERASE LIKE 5-1is a susceptibility factor to plant viruses

Yang

Lüpken

Habekuß

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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“…For example, Mi-1-based resistance is triggered by the member of NBS-LRR class protein that does not have an N-terminal toll-interleukin receptor-like (TIR) domain. During second line of defence two modes of pathogen interaction; direct and indirect has been revealed by the previous research (Caplan et al 2009). …”

Section: The Mechanism Of Natural Resistancementioning

confidence: 99%

How Durable is Root Knot Nematode Resistance in Tomato?

Rashid¹,

Al-Mamun²,

Uddin³

2017

Plant Breed. Biotech.

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Among the plant parasitic nematodes, root knot nematode (RKN) is the most devastating in tomato growing regions. Controlling RKN mostly relies on nematicides. Since chemical application is limited due to adverse environmental effect, alternative approaches are required. Although there are some alternatives, but resistance cultivars are getting popularity in the farmer's field because of simplicity, cost-effective and environment safety. Genes conferring resistance to RKN have already been identified followed by the introgression into elite cultivars. Currently, natural resistance genes (R genes) are used in conventional breeding programmes. Simultaneously, molecular research is going on to characterize and map the linked markers for the detected resistant phenotypes. Currently, it is a prominent threat to maintain the durability of existing R genes. However, durability of host resistance govern by co-evolution of resistance genes from plants and (a)virulence genes from nematodes. So, understanding the mechanisms underlying co-evolution is essential for the durability of R genes. Here we review the existing potential natural resistance in tomato against RKN, currently used resistance mechanisms between RKN and tomato, influential factors of durability of natural resistance genes and opportunity to get more durable resistance in tomato.

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“…In another study, complementary proteomic approaches were used to identify a class of endoplasmic reticulum (ER)-residing chaperones that influence antiviral immune responses (Caplan et al, 2009). In N. benthamiana, the ER proteins ERp57, P5, calreticulin2, and CRT3 are strongly expressed within 2 h of TMV infection in plants expressing the N gene (Caplan et al, 2009).…”

Section: R Gene-mediated Responses To Virus Infectionmentioning

confidence: 99%

Plant Immune Responses Against Viruses: How Does a Virus Cause Disease?

2013

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Plants respond to pathogens using elaborate networks of genetic interactions. Recently, significant progress has been made in understanding RNA silencing and how viruses counter this apparently ubiquitous antiviral defense. In addition, plants also induce hypersensitive and systemic acquired resistance responses, which together limit the virus to infected cells and impart resistance to the noninfected tissues. Molecular processes such as the ubiquitin proteasome system and DNA methylation are also critical to antiviral defenses. Here, we provide a summary and update of advances in plant antiviral immune responses, beyond RNA silencing mechanisms-advances that went relatively unnoticed in the realm of RNA silencing and nonviral immune responses. We also document the rise of Brachypodium and Setaria species as model grasses to study antiviral responses in Poaceae, aspects that have been relatively understudied, despite grasses being the primary source of our calories, as well as animal feed, forage, recreation, and biofuel needs in the 21st century. Finally, we outline critical gaps, future prospects, and considerations central to studying plant antiviral immunity. To promote an integrated model of plant immunity, we discuss analogous viral and nonviral immune concepts and propose working definitions of viral effectors, effector-triggered immunity, and viral pathogen-triggered immunity.

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Induced ER Chaperones Regulate a Receptor-like Kinase to Mediate Antiviral Innate Immune Response in Plants

Cited by 89 publications

References 58 publications

PROTEIN DISULFIDE ISOMERASE LIKE 5-1is a susceptibility factor to plant viruses

PROTEIN DISULFIDE ISOMERASE LIKE 5-1is a susceptibility factor to plant viruses

How Durable is Root Knot Nematode Resistance in Tomato?

Plant Immune Responses Against Viruses: How Does a Virus Cause Disease?

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