Induced development of oxytetracycline tolerance in bacterial communities from soil amended with well-aged cow manure

Jauregi, Leire; Epelde, Lur; Artamendi, Maddi; Blanco, F.; Garbisu, Carlos

doi:10.1007/s10646-023-02650-x

Cited by 4 publications

(1 citation statement)

References 65 publications

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“…The selective pressure that the presence of antibiotics may exert on ARB proliferation in soil is of particular concern, as soil contains a number of bacterial genera of clinical relevance (Serwecińska, 2020). Much interest exists on the relationship between the use of organic amendments of animal (manure, slurry) and/or urban (sewage sludge) origin as fertilizers and the soil resistome (Jauregi et al, 2021a;Jauregi et al, 2021b;Jauregi et al, 2023). Manure is acknowledged as a reservoir of ARB and ARGs (Zhu et al, 2013), which can be disseminated in the environment through horizontal gene transfer (HGT) among bacteria mediated by mobile genetic elements (MGEs) (Heuer et al, 2011;Urra et al, 2019).…”

Section: Metal Contamination and Antibiotic Resistancementioning

confidence: 99%

Enhanced phytoremediation of metal contaminated soils aimed at decreasing the risk of antibiotic resistance dissemination

Garbisu,

Alkorta

2024

Front. Environ. Sci.

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The enhanced phytoremediation of metal contaminated soils holds great promise for the recovery of soil health and functionality, while providing a range of co-benefits, from an environmental and human health perspective, derived from the revegetation of the degraded sites and the concomitant delivery of ecosystem services. Due to diverse evolutionary co-selection mechanisms between metal resistance and antibiotic resistance in bacteria, metal contaminated soils are considered potential reservoirs of antibiotic resistant bacteria (ARB) which can contribute to the existing antibiotic resistance crisis. During the enhanced phytoremediation of metal contaminated soils, the application of organic wastes (e.g., manure, slurry, sewage sludge) as soil amendments can aggravate the risk of antibiotic resistance spread, because they often contain ARB which harbor antibiotic resistance genes (ARGs) that can then be propagated among soil bacterial populations through horizontal gene transfer (HGT). Due to the magnitude and criticality of the antibiotic resistance crisis, as well as the higher risk of spread and dispersal of ARB and ARGs (they make copies of themselves) compared to metals, it is proposed here to aim enhanced phytoremediation strategies towards decreasing the soil resistome (and, hence, the risk of its potential link with the human resistome), while reducing total and/or bioavailable metal concentrations and restoring soil health and the delivery of ecosystem services. To this purpose, a decalogue of practices is tentatively suggested. Finally, a proper management of plant and soil microbial compositions is a most crucial aspect, together with the selection of the right organic wastes and phytoremediation practices.

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Section: Metal Contamination and Antibiotic Resistancementioning

confidence: 99%

Enhanced phytoremediation of metal contaminated soils aimed at decreasing the risk of antibiotic resistance dissemination

Garbisu,

Alkorta

2024

Front. Environ. Sci.

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Biological remediation treatments improve the health of a mixed contaminated soil before significantly reducing contaminant levels

Hidalgo,

Artetxe,

Becerril

et al. 2023

Environ Sci Pollut Res

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Expanding the focus of the One Health concept: links between the Earth-system processes of the planetary boundaries framework and antibiotic resistance

Alkorta,

Garbisu

2024

Reviews on Environmental Health

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The scientific community warns that our impact on planet Earth is so acute that we are crossing several of the planetary boundaries that demarcate the safe operating space for humankind. Besides, there is mounting evidence of serious effects on people’s health derived from the ongoing environmental degradation. Regarding human health, the spread of antibiotic resistant bacteria is one of the most critical public health issues worldwide. Relevantly, antibiotic resistance has been claimed to be the quintessential One Health issue. The One Health concept links human, animal, and environmental health, but it is frequently only focused on the risk of zoonotic pathogens to public health or, to a lesser extent, the impact of contaminants on human health, i.e., adverse effects on human health coming from the other two One Health “compartments”. It is recurrently claimed that antibiotic resistance must be approached from a One Health perspective, but such statement often only refers to the connection between the use of antibiotics in veterinary practice and the antibiotic resistance crisis, or the impact of contaminants (antibiotics, heavy metals, disinfectants, etc.) on antibiotic resistance. Nonetheless, the nine Earth-system processes considered in the planetary boundaries framework can be directly or indirectly linked to antibiotic resistance. Here, some of the main links between those processes and the dissemination of antibiotic resistance are described. The ultimate goal is to expand the focus of the One Health concept by pointing out the links between critical Earth-system processes and the One Health quintessential issue, i.e., antibiotic resistance.

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Induced development of oxytetracycline tolerance in bacterial communities from soil amended with well-aged cow manure

Cited by 4 publications

References 65 publications

Enhanced phytoremediation of metal contaminated soils aimed at decreasing the risk of antibiotic resistance dissemination

Enhanced phytoremediation of metal contaminated soils aimed at decreasing the risk of antibiotic resistance dissemination

Biological remediation treatments improve the health of a mixed contaminated soil before significantly reducing contaminant levels

Expanding the focus of the One Health concept: links between the Earth-system processes of the planetary boundaries framework and antibiotic resistance

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