Induced Delayed Hypersensitivity Reactions and Malignancy

Cole, Milton B.; Ware, Stephen C.; Roberts, E B S Frances

doi:10.1111/j.1532-5415.1967.tb02810.x

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“…The differences between the findings in our study with M. pharyngis and those of Millian and Spigland (10) in subjects of similar age distribution are probably due to differences in the groups studied, as pointed out by Davis and Hsu (12) in making determinations of serum uptake levels of tyrosine and triiodothyronine in various aging populations, and by Cole et al (13) in studying induced hypersensitivity reactions in a group of older patients. These differences emphasize the need for control studies of populations before attempting to relate mycoplasma infection or serological reactions etiologically to any disease process.…”

Section: Discussioncontrasting

confidence: 65%

Mycoplasmas (Pplo) and Disease: Serum Antibody Titers in a Hospital Population of Elderly Patients

Coleman

Cole

Roberts

et al. 1968

J American Geriatrics Society

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In a random sample of eera from a predominantly male group of hoepital patients with an average age of 67, complementdixing antibodies were found in 20 per cent to M. horninis type 1, in 16 per cent to Unknown Strain CE 5, in 1 per cent to M. pharyngis and in 2 per cent to M. pneumoniae.These percentages are lower than thoee reported in the literature for younger populations of patients. Thus the immunological experience with mycoplasmas ( pleuropneumonia-like organisms) varies from one population to another. In general, however, the incidence of mycoplaemal infection eeeme to be lower in older than in younger populatione.The findings also indicate that the mere isolation of these organisms from the sera of patients who manifest a dieease process doee not constitute evidence of an etiological relation. rhip unlees other correlates can be established.Until recently the study of mycoplasmas (PPLO or pleuropneulnonia-like organisms) has been one of the neglected areas of microbiology (I). Since 1962, however, when Chanock and associates (2) isolated and characterized a my coplasma from patients with atypical pneumonia, the importance of these organisms in human disease has been recognized. In 1965 Mufson et al. (3) demonstrated that exudative pharyngitis could be produced in volunteers experimentally infected with Mycoplasma horninis type 1. Several studies have indicated the possibility that mycoplasmas may be involved in other diseases. Fahlberg et al. (4) isolated mycoplasmas from the synovial fluid in 22 of 24 patients with rheumatoid arthritis, and Bartholomew (6) isolated these forms from 14 of 17 patients with rheumatoid arthritis, systemic lupus erythematosus or Reiter's syndrome.Clark and associates (6) established that antibodies to mycoplasmas in human serum can be detected readily by complement fixation, and such studies have been conducted on populations of young patients in whom infection with

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Section: Discussioncontrasting

confidence: 65%