Induced Circular Dichroism Analysis of Thermally Induced Conformational Changes on Protein Binding Sites Under a Crowding Environment
Chikashi Ota,
Tomoya Konishi,
Shun‐ichi Tanaka
et al.
Abstract:Protein‐ligand interactions in crowded cellular environments play a crucial role in biological functions. The crowded environment can perturb the overall protein structure and local conformation, thereby influencing the binding pathway of protein‐ligand reactions within the cellular milieu. Therefore, a detailed understanding of the local conformation is crucial for elucidating the intricacies of protein‐ligand interactions in crowded cellular environments. In this study, we investigated the feasibility of ind… Show more
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