Induced cervical ripening with mifepristone (RU 486) and bioconversion of arachidonic acid in human pregnant uterine cervix in the first trimester

Rådestad, Angelique Flöter; Bygdeman, M.; Green, K.

doi:10.1016/0010-7824(90)90069-8

Cited by 40 publications

(10 citation statements)

References 11 publications

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“…21,22) Onapristone Increased the Expression of MMP-3 mRNA in the Uterine Cervix of Pregnant Rabbits We further examined the effects of onapristone on the expression of uterine cervical MMP-3 mRNA in pregnant rabbit, since MMPs including MMP-1, MMP-3 and MMP-9 are considered to closely participate in uterine cervical ripening at term pregnancy.…”

Section: Effect Of Onapristone On the Dna Concentration Andmentioning

confidence: 99%

An Antiprogesterone, Onapristone, Enhances the Gene Expression of Promatrix Metalloproteinase 3/Prostromelysin-1 in the Uterine Cervix of Pregnant Rabbit.

Imada

Sato

Hashizume

et al. 2002

Biological & Pharmaceutical Bulletin

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Using a progesterone receptor antagonist, onapristone/ZK 98.299, we examined the in-vivo effects of progesterone on the function of uterine cervix during pregnancy. Onapristone was intravenously administered to pregnant rabbits on day 20 post coitum. After 24 h, the antiprogesterone increased the wet weight of the uterine cervix and decreased the DNA concentration in the cervix. In-situ hybridization also indicated that antiprogesterone augmented the expression of matrix metalloproteinase (MMP)-3/stromelysin-1 mRNA in the uterine cervix. These changes are very similar to those observed and reported thus far in ripened and dilated uterine cervix. These results suggest that during pregnancy, progesterone closely participates in the maintenance of the function of uterine cervix by preventing the production of MMPs and thereby destruction of extracellular matrix, and thus add support to the theory that antiprogesterone has the potential to accelerate for the uterine cervical ripening and dilatation.

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Section: Effect Of Onapristone On the Dna Concentration Andmentioning

confidence: 99%

An Antiprogesterone, Onapristone, Enhances the Gene Expression of Promatrix Metalloproteinase 3/Prostromelysin-1 in the Uterine Cervix of Pregnant Rabbit.

Imada

Sato

Hashizume

et al. 2002

Biological & Pharmaceutical Bulletin

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“…The clinical use of antiprogestins such as RU486 has resulted in ripening of the cervix (199,200) although monkey studies show the effect of RU486 on the cervix to be limited and in this respect distinguish progesterone antagonism from the normal course of labor (201). Detailed studies in the guinea pig (108) have demonstrated that the cervix softens dramatically with little, if any, increase in myometrial activity.…”

Section: G Ripening Of the Cervixmentioning

confidence: 99%

Pregnancy Maintenance and Parturition: The Role of Prostaglandin in Manipulating the Immune and Inflammatory Response

Kelly

1994

Endocrine Reviews

153

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“…With regard to mifepristone, several studies have shown that efficacy and side effects, such as vaginal bleeding, are proportional to both dose levels and duration of exposure to the drug (Durlot et al 1988; Lefebvre et al 1990). There is evidence to suggest that the cervical effects of mifepristone occur with doses as low as 50 mg and with duration of time of exposure to the drug of 24 h. However, it has been shown by Radestad et al (1990) that a total dose of 200 mg mifepristone with a 48 h duration of exposure is more effective than with a 36 h duration of exposure. On the other hand, vaginal bleeding before operation is twice as frequent (50%) in the 48 h time scale as in the 36 h time scale (25%).…”

Section: Discussionmentioning

confidence: 99%

“…Firstly, mifepristone was given 48 h before operation, instead of 36 h used by Henshaw and Templeton (1991). Radestad et al (1990) also have shown that a 48 h administration schedule reduces the cervical stiffness significantly more than a 36 h schedule. Secondly, our study was a nonrandomised study, and the mean gest‐ational age was slightly greater, although not significantly, in the mifepristone group.…”

Section: Discussionmentioning

confidence: 99%

Effects of gemeprost and mifepristone on the mechanical properties of the cervix prior to first trimester termination of pregnancy

Carbonne

Brennand

Maria

et al. 1995

BJOG

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Objective To study the effects of oral mifepristone and vaginal gemeprost on the mechanical properties of the cervix prior to first trimester termination of pregnancy by vacuum aspiration. Design A comparative study. Each patient served as her own control. Setting The Royal Infirmary of Edinburgh, Scotland, UK. Subjects Forty nulliparous women at six to twelve weeks of pregnancy. Interventions The women received either gemeprost (1 mg) 3 h prior to termination of pregnancy or mifepristone (200 mg) 48 h before operation. Main outcome measures Two different objective methods of assessment of the mechanical properties of the cervix, one measuring the distensibility of the cervix before drug administration and immediately before the operation, and the other measuring the force necessary to dilate the cervix; incidence of new symptoms following drug intake; immediate complications and estimated blood loss. Results Both treatments significantly increased cervical distensibility. Baseline dilatation was greater in the mifepristone group. The force required to dilate the cervix was significantly reduced in mifepristone‐treated patients, There was a good correlation between the two different methods of assessment of the mechanical properties of the cervix only in the gemeprost group. Conclusion Cervagem and mifepristone can be used to increase cervical distensibility. Cervical dilatation is easier with a 48 h regimen of mifepristone than with gemeprost.

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Induced cervical ripening with mifepristone (RU 486) and bioconversion of arachidonic acid in human pregnant uterine cervix in the first trimester

Cited by 40 publications

References 11 publications

An Antiprogesterone, Onapristone, Enhances the Gene Expression of Promatrix Metalloproteinase 3/Prostromelysin-1 in the Uterine Cervix of Pregnant Rabbit.

An Antiprogesterone, Onapristone, Enhances the Gene Expression of Promatrix Metalloproteinase 3/Prostromelysin-1 in the Uterine Cervix of Pregnant Rabbit.

Pregnancy Maintenance and Parturition: The Role of Prostaglandin in Manipulating the Immune and Inflammatory Response

Effects of gemeprost and mifepristone on the mechanical properties of the cervix prior to first trimester termination of pregnancy

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