Indoor salt water baths followed by artificial ultraviolet B light for chronic plaque psoriasis

Peinemann, Frank; Harari, Marco; Peternel, Sandra; Chan, Thalia; Gambichler, Thilo

doi:10.1002/14651858.cd011941

Cited by 6 publications

(8 citation statements)

References 48 publications

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“…Our search in the Cochrane library retrieved six protocols that in the future may present results of relevance for the clinical question of this review. These protocols, which have been published in the Cochrane Library, will assess the following: interventions for guttate psoriasis; 18 methotrexate for psoriasis; 21 indoor salt water baths followed by artificial ultraviolet B light for chronic plaque psoriasis; 22 lifestyle changes for treating psoriasis; 23 antistreptococcal interventions for guttate and chronic plaque psoriasis 19 ; and complementary therapies for chronic plaque psoriasis. 24 Regarding clinical implications, only two Cochrane SRs provided high-quality evidence relating to use of anti-TNF agents for psoriasis in pediatric patients and use of combined therapy of steroids and vitamin D for scalp psoriasis.…”

Section: Discussionmentioning

confidence: 99%

What do Cochrane systematic reviews say about interventions for treating psoriasis?

et al. 2018

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Section: Discussionmentioning

confidence: 99%

What do Cochrane systematic reviews say about interventions for treating psoriasis?

et al. 2018

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“…We conducted an electronic literature database search on June 4, 2019 without applying any limits in the Skin Group Specialized Register (CRS), the Cochrane Central Register of Controlled Trials (CENTRAL) 2019, Issue 6 in the Cochrane Library, MEDLINE via Ovid (from 1946), Embase via Ovid (from 1974), and LILACS (Latin American and Caribbean Health Science Information database, from 1982). The strategies of the electronic searches including online trials registers and other sources are provided with the original Cochrane Review 10 …”

Section: Methodsmentioning

confidence: 99%

“…This article is an abridged version of a Cochrane Review published in The Cochrane Library 10 . While preparing this systematic review, we endorsed the PRISMA statement, adhered to its principles and conformed to its checklist 11 …”

Section: Methodsmentioning

confidence: 99%

Indoor balneophototherapy for chronic plaque psoriasis: Abridged Cochrane Review

Peinemann

Harari

Peternel

et al. 2020

Dermatologic Therapy

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Artificial exposure to ultraviolet B light (UVB) while soaking in an indoor salt bath, also called balneophototherapy, could simulate the natural exposure to the sun while bathing in the Dead Sea. We aimed to assess the effects of this intervention on patients with chronic plaque psoriasis. We searched CENTRAL, MEDLINE, Embase, and LILACS up to June 2019. We included randomized controlled trials (RCTs). The primary efficacy outcome was psoriasis area and severity index (PASI)‐75 to detect people with a 75% or more reduction in the PASI score from baseline. The primary adverse outcome was treatment‐related adverse events requiring withdrawal. We included eight RCTs (2105 participants; 1976 analyzed). With respect to PASI‐75, two studies found that salt bath + UVB may improve psoriasis when compared to UVB alone (risk ratio 1.71, 95% confidence interval 1.24 to 2.35; 278 participants). With respect to treatment‐related adverse events requiring withdrawal, two other studies found little to no difference when compared to UVB alone (risk ratio 0.96, 95% confidence interval 0.35 to 2.64; 404 participants). Salt bath + UVB could improve psoriasis when compared to UVB alone, though, results are based on a limited number of studies and provide low‐certainty evidence.

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“…2 However, the evidence underlying clinical efficacy, such as longer remission from disease and higher dermatology-related quality of life, has not yet been clearly evaluated. In a Cochrane review, 3 we evaluated whether balneophototherapy would improve the skin of patients with chronic plaque psoriasis compared with UVB alone.…”

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confidence: 99%

“…Peinemann iD , 1 M. Harari,2 S. Peternel iD ,3,4 T. Chan, 5 D. Chan,6 A.M. Labeit 7 and T.Gambichler iD 8 1 Pediatric Oncology and Hematology, Children's Hospital, University of Cologne, Cologne, Germany; 2 Dead Sea and Arava Science Center, Dead Sea Branch, Ein Bokek, Israel; 3 Department of Dermatovenereology, Clinical Hospital Center Rijeka, Rijeka, Croatia; 4 University of Rijeka, Faculty of Medicine, Rijeka, Croatia; 5 Faculty of Life Sciences & Medicine, King'sConflicts of interest: M.H., besides working as a researcher at the Dead Sea and Arava Science Centre, is the medical director at the DMZ Medical Centre, which provides Dead Sea climatotherapy. T.G., since 1998, has been performing research in the field of indoor salt water baths followed by artificial ultraviolet B; and is the author of Gambichler 2001 (included study) and Gambichler 2000b (excluded study).…”

mentioning

confidence: 99%