Indoor-related microbe damage induces complement system activation in building users

Atosuo, Janne; Karhuvaara, Outi; Suominen, Eetu N.; Vilén, Liisa; Nuutila, Jari; Putus, Tuula

doi:10.1177/1753425920966641

“…1) n=numbers of samples, 2) Cl=confidence limit. 3) Numbers in the same column followed by the same letter are not significantly different. 4) P-values for comparisons of bacterial concentrations between room types.…”

Section: Room-to-room Variationmentioning

confidence: 98%

Airborne bacterial species in indoor air and association with physical factors

Madsen

¹

,

Moslehi-Jenabian

²

,

Frankel

³

et al. 2023

Preprint

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The aim of this study is to obtain knowledge about which cultivable bacterial species are present in indoor air in homes, and whether the concentration and species composition of airborne bacteria is associated with different factors. Measurements have been performed for one whole year inside different rooms in 5 homes and once in 52 homes. Within homes, a room-to-room variation for concentrations of airborne bacteria was found, but an overlap in bacterial species was found across rooms. Eleven species were found very commonly and included: Acinetobacter lowffii, Bacillus megaterium, B. pumilus, Kocuria carniphila, K. palustris, K. rhizophila, Micrococcus flavus, M. luteus, Moraxella osloensis, and Paracoccus yeei. The concentrations of gram-negative bacteria in general and the species P. yeei were significantly associated with the season with highest concentrations in spring. The concentrations of P. yeei, K. rhizophila, and B. pumilus were associated positively with relative humidity, and concentrations of K. rhizophila were associated negatively with temperature and air change rate. Micrococcus flavus concentrations were associated negatively with air change rate. Overall, this study identified species which are commonly present in indoor air in homes, and that the concentrations of some species were associated with the factors: season, air change rate, and relative humidity.

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“…1) n=numbers of samples, 2) Cl=confidence limit. 3) Numbers in the same column followed by the same letter are not significantly different. 4) P-values for comparisons of physical factors or bacterial concentrations between room types.…”

Section: Room-to-room Variationmentioning

confidence: 98%

“…Airborne bacteria in indoor environments are confirmed or presumed causal agents of various infectious diseases 1,2 . In addition, airborne bacteria are inflammogenic 3 and seem to be involved in either an increase or decrease in the risk of developing asthma and atopy 4,5 . Indoor work activities such as e.g.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Airborne bacterial species in indoor air and association with physical factors

Madsen

¹

,

Moslehi-Jenabian

²

,

Frankel

³

et al. 2023

Preprint

0

View full text Add to dashboard Cite

The aim of this study is to obtain knowledge about which cultivable bacterial species are present in indoor air in homes, and whether the concentration and diversity of airborne bacteria are associated with different factors. Measurements have been performed for one whole year inside different rooms in 5 homes and once in 52 homes. Within homes, a room-to-room variation for concentrations of airborne bacteria was found, but an overlap in bacterial species was found across rooms. Eleven species were found very commonly and included: Acinetobacter lowffii, Bacillus megaterium, B. pumilus, Kocuria carniphila, K. palustris, K. rhizophila, Micrococcus flavus, M. luteus, Moraxella osloensis, and Paracoccus yeei. The concentrations of gram-negative bacteria in general and the species P. yeei were significantly associated with the season with the highest concentrations in spring. The concentrations of P. yeei, K. rhizophila, and B. pumilus were associated positively with relative humidity, and concentrations of K. rhizophila were associated negatively with temperature and air change rate. Micrococcus flavus concentrations were associated negatively with air change rate. Overall, this study identified species which are commonly present in indoor air in homes, and that the concentrations of some species were associated with the factors: season, air change rate, and relative humidity.

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“…The loss of biological diversity promotes dysbiosis, imbalances in the microbial ecosystem on or within the body, and loss of tolerance to environmental microbes [ 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 ]. Dysbiosis decreases resilience against changes in environmental exposure and promotes systemic subclinical inflammation, allergy, and asthma [ 44 , 45 , 46 , 47 ], symptoms also associated with wet buildings [ 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 ]. The pathophysiological mechanism behind the morbidity associated with wet buildings is still an open question [ 59 , 60 , 61 , 62 , 63 ], but enhancement of dysbiosis, loss of tolerance to environmental microbes, and activation of inflammasomes by exposure to immunoreactive antimicrobial substances from wet, “moldy” buildings cannot be excluded [ 13 , 35 , 44 , 51 , 54 , 56 , 57 , 58 , 64 ].…”

Section: Introductionmentioning

confidence: 99%

Melinacidin-Producing Acrostalagmus luteoalbus, a Major Constituent of Mixed Mycobiota Contaminating Insulation Material in an Outdoor Wall

Andersson

¹

,

Salo

²

,

Mikkola

³

et al. 2021

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Occupants may complain about indoor air quality in closed spaces where the officially approved standard methods for indoor air quality risk assessment fail to reveal the cause of the problem. This study describes a rare genus not previously detected in Finnish buildings, Acrostalagmus, and its species A. luteoalbus as the major constituents of the mixed microbiota in the wet cork liner from an outdoor wall. Representatives of the genus were also present in the settled dust in offices where occupants suffered from symptoms related to the indoor air. One strain, POB8, was identified as A. luteoalbus by ITS sequencing. The strain produced the immunosuppressive and cytotoxic melinacidins II, III, and IV, as evidenced by mass spectrometry analysis. In addition, the classical toxigenic species indicating water damage, mycoparasitic Trichoderma, Aspergillus section Versicolores, Aspergillus section Circumdati, Aspergillus section Nigri, and Chaetomium spp., were detected in the wet outdoor wall and settled dust from the problematic rooms. The offices exhibited no visible signs of microbial growth, and the airborne load of microbial conidia was too low to explain the reported symptoms. In conclusion, we suggest the possible migration of microbial bioactive metabolites from the wet outdoor wall into indoor spaces as a plausible explanation for the reported complaints.

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Indoor-related microbe damage induces complement system activation in building users

Cited by 7 publications

References 26 publications

Airborne bacterial species in indoor air and association with physical factors

Airborne bacterial species in indoor air and association with physical factors

Airborne bacterial species in indoor air and association with physical factors

Melinacidin-Producing Acrostalagmus luteoalbus, a Major Constituent of Mixed Mycobiota Contaminating Insulation Material in an Outdoor Wall

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