Indoor molds, bacteria, microbial volatile organic compounds and plasticizers in schools ? associations with asthma and respiratory symptoms in pupils

Kim, Jeong-Lim; Elfman, Lena; Mi, Yahong; Wieslander, Gunilla; Smedje, Greta; Norbäck, Dan

doi:10.1111/j.1600-0668.2006.00466.x

Cited by 181 publications

(143 citation statements)

References 55 publications

(78 reference statements)

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“…Recently, LOGUE et al [31] , respectively. Similar concentrations were found in offices or schools [32][33][34][35]. In developing or emerging countries, compared with industrialised ones, higher indoor concentrations are often observed [3], in particular for nitrogen dioxide and PM2.5, due to differences in cooking and heating habits (see section on rural areas).…”

Section: Geographical Variations In Iaq In Industrialised Countriesmentioning

confidence: 53%

“…It is important to point out that adjusted associations were not assessed in that latter study. MVOCs have been assessed in only three epidemiological studies [33,60,61]. Two investigations have dealt with MVOC concentration in classrooms, and found a significant relation between it and the risks of wheezing, asthma and nocturnal breathlessness [33,60].…”

Section: Mouldsmentioning

confidence: 99%

“…MVOCs have been assessed in only three epidemiological studies [33,60,61]. Two investigations have dealt with MVOC concentration in classrooms, and found a significant relation between it and the risks of wheezing, asthma and nocturnal breathlessness [33,60]. More recently, positive associations were observed between a fungal index assessed with MVOCs and current asthma (8.6%) and chronic bronchitis-like symptoms (8.4%) in the inhabitants of the OQAI representative sample of the 24 million dwellings of metropolitan France (n5567), especially in rural areas (OR 2.95 (95% CI 1.10-7.95) and OR 3.35 (95% CI 1.33-8.48), respectively).…”

Section: Mouldsmentioning

confidence: 99%

“…Although most studies focused on adverse respiratory effects of moulds, inverse associations were also observed between mould exposure and the risk of allergic/respiratory symptoms in young children [33,57,63]. The PIAMA (Prevention and Incidence of Asthma and Mite Allergy) study suggested a protective effect of early exposure to mould on asthma [57].…”

Section: Mouldsmentioning

confidence: 99%

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Respiratory health and indoor air pollutants based on quantitative exposure assessments

et al. 2012

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We reviewed the main epidemiological studies that evaluate the respiratory effects of indoor air pollutants quantitatively in industrialised countries. Consistent results support short-term (aggravation) and, although more rarely, long-term (prevalence augmentation) effects on asthma, chronic bronchitis and chronic obstructive pulmonary disease (COPD) in indoor settings with poor air quality. Environmental tobacco smoke is one of the most important risks for respiratory symptoms and diseases worldwide. The evidence is also reliable for indoor nitrogen dioxide and particulate matter, which have been associated with asthma, bronchitis and COPD. Whereas formaldehyde and volatile organic compounds seem to be the main pollutants in indoor settings, relevant papers on their respiratory effects are still scarce, and limited to asthma and bronchitis. Moulds have been associated with an increased risk of asthma and COPD. Contradictory results have been found between endotoxins and asthma. The role of phthalates, persistent organic pollutants and flame retardants in respiratory diseases remains to be established. Results from rural areas of industrialised countries indicate that exposure to some indoor bio-contaminants might be protective in early life, while it is associated with adverse respiratory adverse effects in adulthood. Studies focusing on indoor air pollutants should be developed to better understand their involvement in the inception and aggravation of respiratory diseases.

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Section: Geographical Variations In Iaq In Industrialised Countriesmentioning

confidence: 53%

Section: Mouldsmentioning

confidence: 99%

Section: Mouldsmentioning

confidence: 99%

Section: Mouldsmentioning

confidence: 99%

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Respiratory health and indoor air pollutants based on quantitative exposure assessments

et al. 2012

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“…The exact concentration of any given fungal VOC in water-damaged, moldy buildings is difficult to measure because concentrations vary depending on the ventilation rate, moisture, temperature, and other parameters. However, reported concentrations of 1-octen-3-ol in moldy buildings and classrooms range from 0.2 μg/m 3 (0.00004 ppm) up to 900 μg/m 3 (0.16 ppm) (15,(30)(31)(32).…”

Section: Discussionmentioning

confidence: 99%

Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration

Inamdar

Hossain

Bernstein

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

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Parkinson disease (PD) is the most common movement disorder and, although the exact causes are unknown, recent epidemiological and experimental studies indicate that several environmental agents may be significant risk factors. To date, these suspected environmental risk factors have been man-made chemicals. In this report, we demonstrate via genetic, biochemical, and immunological studies that the common volatile fungal semiochemical 1-octen-3-ol reduces dopamine levels and causes dopamine neuron degeneration in Drosophila melanogaster. Overexpression of the vesicular monoamine transporter (VMAT) rescued the dopamine toxicity and neurodegeneration, whereas mutations decreasing VMAT and tyrosine hydroxylase exacerbated toxicity. Furthermore, 1-octen-3-ol also inhibited uptake of dopamine in human cell lines expressing the human plasma membrane dopamine transporter (DAT) and human VMAT ortholog, VMAT2. These data demonstrate that 1-octen-3-ol exerts toxicity via disruption of dopamine homeostasis and may represent a naturally occurring environmental agent involved in parkinsonism.building-related illness | mold | mushroom alcohol

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Bisphenol A Exposure and the Development of Wheeze and Lung Function in Children Through Age 5 Years

et al. 2014

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Importance Bisphenol A (BPA), a prevalent endocrine disrupting chemical, has been associated with wheezing in children, but few studies have examined its impact on lung function or wheeze in older children. Objective The objectives of this study were to test whether BPA exposure was associated with lung function, with wheeze, and with pattern of wheeze in children over the first five years. Design A birth cohort study, enrolled during early pregnancy. Setting Greater Cincinnati, Ohio area. Participants 398 mother-infant dyads,. Exposure We collected maternal urine during pregnancy (16 and 28 weeks) and child urine annually to assess gestational and child BPA exposure. Main Outcome Measures We assessed parent-reported wheeze every 6 months for 5 years and measured child forced expiratory volume in one second (FEV1) at age 4 and 5 years. We evaluated associations of BPA with respiratory outcomes: FEV1, child wheeze, and wheeze phenotype. Results Urinary BPA concentrations and FEV1 data were available for 208 children, and urinary BPA and parent-reported wheeze data were available for 360 children. Mean maternal urinary BPA ranged from 0.5 to 316 μg/g of creatinine. In multivariable analysis, every 10-fold increase in mean maternal urinary BPA was associated with 14.2% decrease in %FEV1 at 4 years (95% CI −24.5, −3.9) but no association was found at 5 years. In multivariable analysis, every 10-fold increase in mean maternal urinary BPA concentration was marginally associated with a 55% increase in the odds of wheezing (OR 1.55, 95% CI 0.91, 2.63). While mean maternal urinary BPA concentration was not associated with wheeze phenotypes, a 10-fold increase in 16 week maternal BPA was associated with a 4.3 fold increase in odds of persistent wheeze (OR 4.3, 95% CI 1.4, 13.3). Child BPA concentrations were not associated with FEV1 or wheeze. Conclusions and Relevance These results provide evidence that suggest that prenatal, but not postnatal, exposure to BPA is associated with diminished lung function and the development of persistent wheeze in children.

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Indoor molds, bacteria, microbial volatile organic compounds and plasticizers in schools ? associations with asthma and respiratory symptoms in pupils

Cited by 181 publications

References 55 publications

Respiratory health and indoor air pollutants based on quantitative exposure assessments

Respiratory health and indoor air pollutants based on quantitative exposure assessments

Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration

Bisphenol A Exposure and the Development of Wheeze and Lung Function in Children Through Age 5 Years

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