A close correlation between CO2 concentration and aerosol enables the wide utilization of CO2 concentration as a good representation of Severe Acute Respiratory Syndrome-Coronavirus-2 infection airborne transmission. On the other side, many indoor air-quality monitoring devices have been developed for indoor monitoring applications. However, most of them are multiparameter air-quality sensor systems and tend to consume relatively high power, are relatively large devices, and are fairly expensive; therefore, they not meet the requirement for indoor monitoring applications. This paper presents a smart wireless sensor node that can measure and monitor CO2 concentration levels. The node was designed to meet the requirements of indoor air-quality monitoring applications by considering several factors, such as compact size, low cost, and low power, as well as providing real-time, continuous, reliable, and remote measurement. Furthermore, the commercial off-the-shelf and low-power consumption components are chosen to fit with the low-cost development and reduce energy consumption. Moreover, a low-power algorithm and cloud-based data logger also were applied to minimize the total power consumption. This power strategy was applied as a preliminary development toward an autonomous sensor node. The node has a compact size and consumes low energy for one cycle of CO2 measurement, accompanied by high accuracy with very low measurement error. The experiment result revealed the node could measure and monitor in real-time continuous, reliable, and remote CO2 concentration levels in indoor and outdoor environments. A user interface visualizes CO2 concentration graphically and numerically using the Adafruit platform for easy accessibility over the Internet of Things. The developed node is very promising and suitable for indoor CO2 monitoring applications with the acquired data that could be utilized as an indicator to minimize the risk of indoor Severe Acute Respiratory Syndrome-Coronavirus-2 airborne transmission.