Indoor Air Pollution and the Health of Vulnerable Groups: A Systematic Review Focused on Particulate Matter (PM), Volatile Organic Compounds (VOCs) and Their Effects on Children and People with Pre-Existing Lung Disease

Maung, Tun Z.; Bishop, Jack E.; Holt, Eleanor; Turner, Alice; Pfrang, Christian

doi:10.3390/ijerph19148752

Cited by 107 publications

(49 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The interior environment of a house is contaminated by various gases and particles produced during various human activities such as cooking, smoking, burning, candles, insecticides, incense sticks, etc [10]. The current study discovered that poor indoor air quality has a significant association with respiratory illness.…”

Section: Discussionmentioning

confidence: 64%

Geospatial Mapping of Indoor Air Quality and Respiratory Illnesses in an Urban Slum

Shah¹,

Shabadi²,

Karkra³

et al. 2023

Cureus

View full text Add to dashboard Cite

IntroductionAir pollution is a well-recognized determinant of health. The general perception has focused primarily on outdoor pollution, and indoor pollution which may be due to smoking, biomass use, an extension of outdoor pollution, etc. has been neglected. It is therefore imperative to understand the levels of indoor pollution and find out if these are associated with high rates of illnesses, particularly, respiratory diseases. Material and methodsThis was a cross-sectional study involving 300 houses and 727 participants in an urban slum, selected through simple random sampling. Indoor air quality was assessed using the Prana C -Air Plus air quality monitor (Prana Air, New Delhi, India). The instrument detected formaldehyde, air quality index (AQI), temperature, humidity, PM2.5, PM10 particles, and total volatile organic (TVO) compounds. Sociodemographic details were noted, and geospatial mapping was done using Q-GIS software (www.qgis.org). A questionnaire was used to survey the residents of those houses. Ethical committee clearance was obtained before starting the project. ResultsThe mean distribution of pollution parameters over the entire study area was AQI -67.4±65.48, PM 2.5 -37.6±35.82 μg/m 3 , formaldehyde -0.09±0.37 mg/m 3 , PM 10 -43.9±38.59 μg/m 3 , TVO compounds -0.43±2.13 mg/m 3 , CO 2 -1128.9±323.86 ppm, temperature -23.7±21.2 degree Celsius, and PM 1 -24.3±20.5 μg/m 3 ; 2.6% of the participants had respiratory diseases, and a significant association was found between the AQI, TVO compounds and ventilation, and respiratory diseases (p<0.05). ConclusionIndoor air pollution not unlike outdoor pollution can have dramatic health effects and needs to be addressed to lower the overall respiratory disease burden. The AQI, TVOC, and poor ventilation/cross-ventilation are associated with respiratory illnesses. Geospatial mapping shows a concentration of cases in areas of high pollution.

show abstract

Section: Discussionmentioning

confidence: 64%

Geospatial Mapping of Indoor Air Quality and Respiratory Illnesses in an Urban Slum

Shah¹,

Shabadi²,

Karkra³

et al. 2023

Cureus

View full text Add to dashboard Cite

show abstract

“…At indoor level, in order to improve people’s health conditions, we suggest increasing the ventilation rate in the work places and houses. Indeed, previous studies have shown how an improvement in indoor air given by better ventilation increases productivity and prevents pathological conditions such as rhinitis and the risk of allergic symptoms [ 24 , 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

Consequences of exposure to pollutants on respiratory health: From genetic correlations to causal relationships

et al. 2022

View full text Add to dashboard Cite

Modern society grew rapidly over the last few decades and this led to an alarming increase in air pollutants and a worsening of the human health, especially in relation to the respiratory system. Indeed, chronic respiratory diseases were the third main cause of death in 2017, with over 3 million of deaths. Furthermore, the pollution has considerable consequences both for burden medical expenses and environmental. However, the mechanisms linking pollutants to the onset of these diseases remain unclear. Thus, in this study we addressed this problem through the United Kingdom BioBank database, analyzing 170 genome-wide association studies (103 related to respiratory diseases and 67 related to pollutants). We analyzed the genetic correlations and causal relationships of these traits, leveraging the summary statistics and bioinformatics packages such as Linkage Disequilibrium Score Regression and Latent Causal Variable. We obtained 158 significant genetic correlations and subsequently we analyzed them through the Latent Causal Variable analysis, obtaining 20 significant causal relationships. The most significant were between "Workplace full of chemicals or other fumes: Sometimes" and “Condition that has ever been diagnosed by a doctor: Asthma” and between “Workplace very dusty: Sometimes” and “Condition that has ever been diagnosed by a doctor: Emphysema or chronic bronchitis”. Finally, we identified single nucleotide polymorphisms independently associated with sveral pollutants to analyze the genes and pathways that could be involved in the onset of the aforementioned respiratory system disorders and that could be useful clinical target. This study highlighted how crucial are the air condition of the working environments and the type of transport used in the onset of respiratory-related morbidity. Based on that, we also suggested some interventions, in order to improve quality life and develop new and eco-friendly society and life style, such as improving indoor air circulation, the use of public transport and urban reforestation.

show abstract

“…Volatile organic compounds (VOCs) in indoor air are believed to contribute to sick building syndrome and multiple chemical sensitivity (Win-Shwe et al, 2013;Redlich et al, 1997). They could also exacerbate asth-ma and chronic obstructive pulmonary disease (COPD) (Maung et al, 2022;Bentayeb et al, 2015). From 1997 through 2002, the Ministry of Health, Labour, and Welfare (MHLW) in Japan established indoor air guidelines to maintain public health for 13 VOCs and semi-volatile organic compounds, including aldehydes, alkanes, aromatic hydrocarbons, pesticides, and phthalates (MHLW, 2000a(MHLW, , 2000b(MHLW, , 2001(MHLW, , 2002.…”

Section: Introductionmentioning

confidence: 99%

Species differences in activation of TRPA1 by resin additive-related chemicals relevant to indoor air quality

et al. 2023

View full text Add to dashboard Cite

Transient Receptor Potential Ankyrin 1 (TRPA1), which is expressed in the airways, has causative and exacerbating roles in respiratory diseases. TRPA1 is known as a target of sick building syndrome-related air pollutants, such as formaldehyde. Thus, an in vitro TRPA1 activation assay would be useful for predicting the potential risk of air pollution. In this study, we used human TRPA1 (hTRPA1)and mouse TRPA1 (mTRPA1)-expressing cell lines to measure TRPA1 activation by the emerging indoor air pollutants 2-ethyl-1-hexanol (2-EH), a mixture of 2,2,4-trimethyl-1,3-pentanediol 1-and 3-monoisobutyrate (Texanol), and 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (TXIB). The results indicated that 2-EH activated both hTRPA1 and mTRPA1 in a concentration-dependent manner, whereas TXIB did not activate hTRPA1 or mTRPA1. Texanol also activated hTRPA1 in a concentration-dependent manner. In contrast, a bell-shaped concentration-dependent curve was observed for mouse TRPA1 activation by Texanol, indicating inhibitory effects at a higher concentration range, which was also reported for menthol, a typical TRPA1 modulator. To further elucidate the mechanism underlying the species difference in TRPA1 activation by Texanol, V875G and G878V mutations were introduced into hTRPA1 and mTRPA1, respectively, which were reported to be key mutations for the inhibitory effect of menthol. These mutations switched the inhibitory effects of Texanol; thus, hTRPA1/V875G, but not mTRPA1/ G878V, was inhibited at higher concentrations of Texanol. These results indicate that Texanol shares an interaction site with menthol. Overall, these findings suggest that careful interpretation is necessary when extrapolating rodent TRPA1-dependent toxicological effects to humans, especially with respect to the risk assessment of indoor air pollutants.

show abstract

Indoor Air Pollution and the Health of Vulnerable Groups: A Systematic Review Focused on Particulate Matter (PM), Volatile Organic Compounds (VOCs) and Their Effects on Children and People with Pre-Existing Lung Disease

Cited by 107 publications

References 74 publications

Geospatial Mapping of Indoor Air Quality and Respiratory Illnesses in an Urban Slum

Geospatial Mapping of Indoor Air Quality and Respiratory Illnesses in an Urban Slum

Consequences of exposure to pollutants on respiratory health: From genetic correlations to causal relationships

Species differences in activation of TRPA1 by resin additive-related chemicals relevant to indoor air quality

Contact Info

Product

Resources

About