Indoor air pollution and the risk of orofacial clefts in a rural population in Shanxi province, China

Liu, Yingying; Wang, Bin; Li, Zhiwen; Zhang, Le; Liu, Jufen; Ren, Aiguo

doi:10.1002/bdra.23522

Cited by 15 publications

(11 citation statements)

References 29 publications

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“… 16 The risk of alcohol use and smoking has been reported in previous studies; however, we did not observe a significant risk. 17 , 18 Future studies need to further examine parental and environmental factors, including passive smoking, 19 endocrine disrupting chemicals, 20 indoor air pollution, 21 folate, 22 , 23 supplemental vitamins, 24 – 26 and stress. 27 , 28 …”

Section: Discussionmentioning

confidence: 99%

Prevalence and Risk of Birth Defects Observed in a Prospective Cohort Study: The Hokkaido Study on Environment and Children’s Health

Hanaoka

Tamura

Ito

et al. 2018

Journal of Epidemiology

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BackgroundPrevalence rates of all anomalies classified as birth defects, including those identified before the 22nd gestational week, are limited in published reports, including those from the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR). In our birth cohort study, we collected the data for all birth defects after 12 weeks of gestation.MethodsSubjects in this study comprised 19,244 pregnant women who visited one of 37 associated hospitals in the Hokkaido Prefecture from 2003 through 2012, and completed follow-up. All birth defects after 12 weeks of gestation, including 55 marker anomalies associated with environmental chemical exposures, were recorded. We examined parental risk factors for birth defects and the association between birth defects and risk of growth retardation.ResultsPrevalence of all birth defects was 18.9/1,000 births. The proportion of patients with birth defects delivered between 12 and 21 weeks of gestation was approximately one-tenth of all patients with birth defects. Among those with congenital malformation of the nerve system, 39% were delivered before 22 weeks of gestation. All patients with anencephaly and encephalocele were delivered before 22 weeks of gestation. We observed different patterns of parental risk factors between birth defect cases included in ISBDSR and cases not included. Cases included in ISBDSR were associated with an increased risk of preterm birth. Cases not included in ISBDSR were associated with an increased risk of being small for gestational age at term.ConclusionsData from our study complemented the data from ICBDSR. We recommend that birth defects not included in ICBDSR also be analyzed to elucidate the etiology of birth defects.

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Section: Discussionmentioning

confidence: 99%

Prevalence and Risk of Birth Defects Observed in a Prospective Cohort Study: The Hokkaido Study on Environment and Children’s Health

Hanaoka

Tamura

Ito

et al. 2018

Journal of Epidemiology

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“…Although the correlation between secondhand smoke and CMs has been a concern for several decades, different studies obtained somewhat different results . Most studies reported a significantly increased risk for cardiovascular system malformations, whereas a study by Wasserman et al did not .…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, study results regarding the association have been inconsistent. Some studies suggested that exposure to secondhand smoke in nonsmoking women significantly increases the risk of CMs in their offspring, whereas others showed no relation or even a protective effect . In 2010, two meta‐analyses were conducted to examine the association between secondhand smoke and CMs .…”

Section: Introductionmentioning

confidence: 99%

“…Since those meta‐analyses, however, many original studies related to this topic have emerged. Many of these studies were conducted in different regions and have investigated the association between secondhand smoke and organ‐system malformations . It is therefore possible to conduct an updated comprehensive assessment based on the new and previously existing evidence.…”

Section: Introductionmentioning

confidence: 99%

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Congenital malformations are associated with secondhand smoke among nonsmoking women: A meta‐analysis

Zheng

Xie

Yang

et al. 2018

Birth

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Background The association between active maternal smoking and congenital malformations is well established, but little is known about the association between secondhand smoke and congenital malformations. Moreover, studies regarding the association between congenital malformations and secondhand smoke have not yielded consistent results. Methods In July 2018, we searched PubMed, EMBASE, and China Biology Medicine databases for observational studies characterizing the relationship between secondhand smoke and congenital malformations of offspring in nonsmoking women. Two reviewers independently decided on whether a study should be included, did data extraction, and assessed study quality. Pooled risks with 95% confidence intervals were calculated using either the fixed‐effects models or random‐effects models. Further subgroup analyses and sensitivity analyses were performed to explore the potential source of heterogeneity and to examine the robustness of risk estimates. Results Thirty‐three studies with a total of 31 944 cases and 32 335 controls were included. Secondhand smoke exposure was associated with an increased risk of congenital malformations (odds ratio = 1.92; 95% confidence interval 1.61‐2.30). Secondhand smoke was correlated with significantly increased risk for digestive system (1.17 [1.05‐1.32]), nervous system (1.74 [1.33‐2.29]), and cardiovascular system (2.10 [1.32‐3.35]) malformations and for oral clefts (1.87 [1.47‐2.39]). Conclusions Secondhand smoke exposure increases the risk for overall and several organ‐system malformations. These findings highlight the necessity of improving community awareness to prevent secondhand smoke exposure during the preconception and conception periods.

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“…Parental smoking has been considered an important determinant of developmental disorders, but the environmental impact of smoke exposure from cooking and cleft risk has only been mentioned in two existing studies [ 9 , 10 ]. In low-resource countries, biomass cooking fuel is used by approximately 80% of rural households and has been associated with a wide variety of diseases, including stillbirths [ 11 ].…”

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confidence: 99%

The role of smoke from cooking indoors over an open flame and parental smoking on the risk of cleft lip and palate: A case- control study in 7 low-resource countries

Auslander

McKean‐Cowdin

Brindopke

et al. 2020

Journal of Global Health

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Background Cleft is one of the most common birth defects globally and the lack of access to surgery means millions are living untreated. Smoke exposure from cooking occurs infrequently in developed countries but represents a high-proportion of smoke exposure in less-developed regions. We aimed to study if smoke exposure from cooking is associated with an increased risk in cleft, while accounting for other smoke sources. Methods We conducted a population-sampled case-control study of children with cleft lip and/or palate and healthy newborns from Vietnam, Philippines, Honduras, Nicaragua, Morocco, Congo, and Madagascar. Multivariable regression models were used to assess associations between maternal cooking during pregnancy, parental smoking, and household tobacco smoke with cleft. Results 2137 cases and 2014 controls recruited between 2012-2017 were included. While maternal smoking was uncommon (<1%), 58.3% case and 36.1% control mothers cooked over an open fire inside. Children whose mothers reported cook smoke exposure were 49% (95% confidence interval (CI) = 1.2-1.8) more likely to have a child with a cleft. This was consistent in five of seven countries. No significant associations were found for any other smoke exposure. Conclusions Our finding of maternal cook smoke and cleft in low-resource countries, similar to maternal tobacco smoke in high-resource countries, may reflect a common etiology. This relationship was present across geographically diverse countries with variable socioeconomic statuses and access to care. Exposures specific to low-resource settings must be considered to develop public health strategies that address the populations at increased risk of living with cleft and inform the mechanisms leading to cleft development.

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Indoor air pollution and the risk of orofacial clefts in a rural population in Shanxi province, China

Abstract: Periconceptional exposure to IAP from coal combustion and tobacco smoking may increase the risk of OFCs in offsprings of women in Shanxi Province. Birth Defects Research (Part A) 106:708-715, 2016. © 2016 Wiley Periodicals, Inc.

Cited by 15 publications

References 29 publications

Prevalence and Risk of Birth Defects Observed in a Prospective Cohort Study: The Hokkaido Study on Environment and Children’s Health

Prevalence and Risk of Birth Defects Observed in a Prospective Cohort Study: The Hokkaido Study on Environment and Children’s Health

Congenital malformations are associated with secondhand smoke among nonsmoking women: A meta‐analysis

The role of smoke from cooking indoors over an open flame and parental smoking on the risk of cleft lip and palate: A case- control study in 7 low-resource countries

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