Indomethacin prevents post-ERCP pancreatitis in selected high-risk patients

Bonzi, Mattia; Fiorelli, Elisa Maria; Metodologica, Gruppo di Autoformazione

doi:10.1007/s11739-012-0872-z

Cited by 1 publication

(1 citation statement)

References 8 publications

(6 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The most common complication of ERCP is acute pancreatitis. The incidence of post-ERCP pancreatitis (PEP) ranges from 1% to 10% in all-risk patients, and it can even reach 25% in high-risk patients [ 1 ]. Most cases of PEP are mild, but about 10% of the episodes may be severe, resulting in significant morbidity and occasional mortality [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Use of NSAIDs via the Rectal Route for the Prevention of Pancreatitis after ERCP in All-Risk Patients: An Updated Meta-Analysis

Zhao

Lü

2018

Gastroenterology Research and Practice

View full text Add to dashboard Cite

The aim of this study was to assess the efficacy of the rectal administration of nonsteroidal anti-inflammatory drugs (NSAIDs) in preventing post-ERCP pancreatitis (PEP). We searched database for randomized controlled trials (RCTs) comparing periprocedural rectal administration of NSAIDs with placebo for the prevention of PEP. The rectal administration of NSAIDs significantly decreased the incidence of PEP in the whole patient population (odds ratio (OR): 0.44, 95% confidence interval (CI): 0.30–0.64, P < 0.0001), high-risk patients (OR: 0.34, 95% CI: 0.19–0.58, P = 0.0001), and all-risk patients (OR: 0.51, 95% CI: 0.31–0.84, P = 0.008). The incidence of PEP was reduced by indomethacin (OR: 0.54, 95% CI: 0.36–0.82, P = 0.004) and diclofenac (OR: 0.27, 95% CI: 0.15–0.46, P < 0.00001). The administration of NSAIDs before (OR: 0.42, 95% CI: 0.25–0.73, P = 0.002) or after (OR: 0.39, 95% CI: 0.27–0.56, P < 0.00001) ERCP reduced PEP. The NSAIDs were associated with a reduction in mild PEP (OR: 0.55, 95% CI: 0.36–0.83, P = 0.004) and moderate-to-severe PEP (OR: 0.47, 95% CI: 0.28–0.79, P = 0.004). The rectal administration of NSAIDs reduced the incidence of PEP in high-risk and all-risk patients.

show abstract

Section: Introductionmentioning

confidence: 99%