Indomethacin Inhibits Duodenal Mucosal Bicarbonate Secretion and Endogenous Prostaglandin E2 Output in Human Subjects

Selling, John A.

doi:10.7326/0003-4819-106-3-368

Cited by 70 publications

(24 citation statements)

References 20 publications

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“…These are macro-morphologically different from the stripped lesions caused by absolute ethanol or HCl/ethanol. Indomethacin, on its part, is a non-steroidal anti-inflammatory drug which reduces prostaglandin and bicarbonate secretion, as well as gastric mucosal blood flow in animals (Whittle, 1977;Flemstrom et al, 1982;Miller, 1982;Selling et al, 1987), and the role of prostaglandins in gastric mucosal protection is well known (Konturek et al, 1981(Konturek et al, , 1982Robert, 1981). When cytoprotection is significantly reduced by pre-treatment with indomethacin, the cytoprotection is interpreted to be mediated by endogenous prostaglandins.…”

Section: Discussionmentioning

confidence: 99%

Cytoprotective and antioxidant effects of the methanol extract of Eremomastax Speciosa in rats

Amang¹,

Tan²,

Patamaken³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

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Background: Ethno-botanical information shows that Eremomastax speciosa is used in the traditional management of various stomach complaints including gastro-duodenal ulcers. Materials and Methods:In this study, we tested the cytoprotective potential of the whole plant methanol extract (100-200 mg/kg, p.o), against HCl/ethanol, absolute ethanol, cold/restraint stress rats, and pylorus legated rats pre-treated with indomethacin. The effects of the extract on gastric lesion inhibition, the volume of gastric juice, gastric pH, gastric acid output, mucus production and gastric peptic activity were recorded. Oxidative stress parameters were measured in blood and gastric tissue samples obtained from the animals in all the models tested. Results: The extract significantly (p<0.05), reduced the formation of cold/restraint ulcers by (31-60%, inhibition), completely inhibited (100%) the formation of lesions induced by HCl/ethanol at the highest dose, but was less effective against absolute ethanol (22-46% inhibition). The extract (200 mg/kg), significantly reduced lesion formation (P<0.01), gastric acidity (P<0.01), and volume of gastric secretions (P<0.05), in the indomethacin/pylorus ligation model, and did not affect the activity of pepsin in gastric juice. Blood concentrations of antioxidant enzymes (catalase, SOD and GSH), increased significantly and MDA concentrations decreased in all models tested. Conclusion: Cytoprotection by E. speciosa methanol extract was attributed to its ability to reduce acid secretion, and to enhance mucosal defence and in vivo antioxidant status.

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Section: Discussionmentioning

confidence: 99%

Cytoprotective and antioxidant effects of the methanol extract of Eremomastax Speciosa in rats

Amang¹,

Tan²,

Patamaken³

et al. 2013

Afr. J. Trad. Compl. Alt. Med.

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“…However, this cytoprotection was significantly reduced when the experimental animals were pre-treated with indomethacin, a prostaglandin inhibitor. Indomethacin suppresses gastroduodenal bicarbonate secretion, disrupts the mucosal barrier, reduced endogenous prostaglandin biosynthesis as well as reduces gastric mucosal blood flow (10,11,12). Conversely the role of prostaglandins in gastric mucosal protection has been extensively studied (11,13,14,15).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Cassia sieberiana Root Bark Extract on Various Experimental Gastric Ulcer Models in Rats

Nartey¹,

Addo²,

Ofosuhene³

et al. 2011

J. Phyto. Therap.

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The antiulcerogenic effects of the root bark extract of C. sieberiana were studied using various gastric ulcer models in rats. This was to support the rational phytotherapeutic use of Cassia sieberiana root bark extract in managing gastric ulcer. The cytoprotective ability of the extract was tested using the HCl/ethanol and the indomethacin-HCl/ethanol induced gastric lesion models. The healing ability of the extract was tested using the acetic acid induced model. Ulcer index, gastric HCl output, mucus production, pepsin activity and volume of gastric secretion were measured. Oral administration of the abstract (500-1000 mg/kg body weight) inhibited the formation of gastric ulcers induced by . This inhibition was significantly (p <0.05) suppressed by pretreatment of the experimental rats with indomethacin (30 mg/kg i.p). Oral administration of the extract in acetic acid induced ulcers produced significant dose-dependent healing of the gastric ulcers, significantly decreased total gastric HCl output and also significantly increased gastric barrier mucus production but these were not associated with changes in gastric secretion volume or pepsin activity.

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“…NSAIDs disrupt the normal gastric mucosal barrier of bicarbonate and hydrophobic mucus via disturbance of PGs synthesis by inhibition of constitutive COX isoenzyme, COX-1 (Hawkins and Hanks, 2000; Hayllar and Bjarnason, 1995;Selling et al, 1987;Vane, 1971).…”

Section: Discussionmentioning

confidence: 99%

Anti-Inflammatory and Anti-Ulcerogenic Activities of Chantaleela Recipe

Sireeratawong¹,

Khonsung²,

Piyabhan³

et al. 2012

Afr. J. Trad. Compl. Alt. Med.

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Chantaleela recipe is indicated for relieving fever in Thai traditional folk medicine. In the present study, Chantaleela recipe was investigated for anti-inflammatory, analgesic, antipyretic and anti-ulcerogenic activities. In preliminary investigation Chantaleela recipe was found to exert an inhibitory activity on the acute phase of inflammation as seen in ethyl phenylpropiolate-induced ear edema as well as in carrageenan-induced hind paw edema in rats. The results suggest that the anti-inflammatory activity of Chantaleela recipe may be due to an inhibition via cyclooxygenase pathway. In the analgesic test, Chantaleela recipe showed a significant analgesic activity in both the early and late phases of formalin test, but exerted the most pronounced effect in the late phase. The analgesic activity of Chantaleela recipe may act via mechanism at peripheral and partly central nervous system. In antipyretic test, Chantaleela recipe significantly decreased rectal temperature of brewer's yeast-induced hyperthermia rats, probably by inhibiting synthesis and/or release of prostaglandin E 2 in the hypothalamus. Therefore, the key mechanism of anti-inflammatory, analgesic, and antipyretic activity of the Chantaleela recipe likely involves the inhibition of the synthesis and/or release of inflammatory or pain mediators, especially prostaglandins. The oral administration of the Chantaleela recipe reduced ulcer formation in acute gastric ulcer models (EtOH/HCl-, indomethacin-, and stress-induced gastric lesions). In contrast, this recipe did not reduce the secretory rate, total acidity, and increase pH in rat stomach. These results indicated that Chantaleela seem to possess anti-ulcerogenic effect. This activity may be due to the increase of gastric mucosal resistance or potentiation of defensive factors and/or the decrease of aggressive factors but did not associate the anti-secretory activity. Moreover, the high oral doses treated did not cause acute toxicity in rats and the long term oral administration did not produce gastric and ileum lesions.

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Indomethacin Inhibits Duodenal Mucosal Bicarbonate Secretion and Endogenous Prostaglandin E2 Output in Human Subjects

Cited by 70 publications

References 20 publications

Cytoprotective and antioxidant effects of the methanol extract of <i>Eremomastax Speciosa</i> in rats

Cytoprotective and antioxidant effects of the methanol extract of <i>Eremomastax Speciosa</i> in rats

The Effect of <i>Cassia sieberiana</i> Root Bark Extract on Various Experimental Gastric Ulcer Models in Rats

Anti-Inflammatory and Anti-Ulcerogenic Activities of Chantaleela Recipe

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