Indomethacin-induced blood flow distribution in premature and full-term piglets

Dyess, D. Lynn; Peeples, Guy L.; Ardell, Jeffrey L.; Tacchi, Ernest J.; Roberts, W.Scott; Ferrara, John J.; Powell, Randall W.

doi:10.1016/s0022-3468(05)80334-3

Cited by 22 publications

(9 citation statements)

References 18 publications

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“…In the end stage, the histological hallmark of NEC is a ''bland infarct'' characterized by full thickness coagulation (ischemic) necrosis, a paucity of acute inflammatory cells (neutrophils), and a predominantly lymphocytic infiltrate [44,45]. Therefore, investigators have postulated that intestinal ischemia resulting from respiratory distress syndrome or cyanotic congenital heart disease for instance, may be an important inciting event in the pathogenesis of NEC by causing mucosal injury [11,46,47].…”

Section: Intestinal Bacteriamentioning

confidence: 99%

Current concepts regarding the pathogenesis of necrotizing enterocolitis

et al. 2009

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Necrotizing enterocolitis (NEC) is a devastating disease that predominantly affects premature neonates. The mortality associated with NEC has not changed appreciably over the past several decades. The underlying etiology of NEC remains elusive, although bacterial colonization of the gut, formula feeding, and perinatal stress have been implicated as putative risk factors. The disease is characterized by massive epithelial destruction, which results in gut barrier failure. The exact molecular and cellular mechanisms involved in this complex disease are poorly understood. Recent studies have provided significant insight into our understanding of the pathogenesis of NEC. Endogenous mediators such as prostanoids, cyclooxygenases, and nitric oxide may play a role in the development of gut barrier failure. Understanding the structural architecture of the gut barrier and the cellular mechanisms that are responsible for gut epithelial damage could lead to the development of novel diagnostic, prophylactic and therapeutic strategies in NEC.

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Section: Intestinal Bacteriamentioning

confidence: 99%

Current concepts regarding the pathogenesis of necrotizing enterocolitis

et al. 2009

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“…In previous studies, radioactive and fluorescent microsphere deposition has been used to quantitate the effects of hormones and other agents on blood flow to GI tissues or organs (8,9,11,26,30). Therefore, the aim of the current study was to determine the effect of acute GLP-2 infusion on the distribution of blood flow in GI and other visceral organs in TPN-fed neonatal piglets using the fluorescent microsphere deposition method.…”

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confidence: 99%

Glucagon-like peptide-2 acutely increases proximal small intestinal blood flow in TPN-fed neonatal piglets

Stephens¹,

Stoll²,

Cottrell³

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

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“…This issue can be illustrated citing the study by Hofer et al (3), which examined 467 term infants and found that the definitions of the pediatric consensus of SIRS applied to only 53% of cases of early-onset sepsis with positive blood culture, and the sensitivity of the criteria to define SIRS was 20% for thermal instability, 43% for abnormal total WBC count, 87% to respiratory disturbances, and 33% for circulatory signs. In 87 neonates with meningitis, Krebs and Costa (4) showed that clinical findings were often unspecific, confirming the difficulty of early diagnosis of the disease in the neonatal period.…”

Section: Definitions Of Sepsis In Neonatology: a Fundamental Toolmentioning

confidence: 99%