Indomethacin for prevention of ectopic ossification after hip arthroplasty

Kjærsgaard‐Andersen, Per; Schmidt, Steen Asmus

doi:10.3109/17453678608993206

Cited by 60 publications

(11 citation statements)

References 18 publications

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“…Indomethacin and other NSAIDs have been shown to be effective when given prophylactically for PHO [4,7,19], or in patients at risk for this complication [15,18]. Furthermore, the same treatment has been shown to prevent recurrence after excision [9,10] and to prevent recurrence of heterotopic bone after resection in patients with neurological injuries.…”

Section: Discussionmentioning

confidence: 99%

“…In most instances the symptoms are not severe enough to warrant excision [8]. Furthermore resection of PHO almost invariably results in recurrence [6,9,11]. This is not surprising, since the individual's tendency to react with a bone-forming response to surgical trauma seems to be the most important factor in the development of PHO [8,17].…”

Section: Discussionmentioning

confidence: 99%

“…In some patients the disability becomes serious enough to warrant resection. The risk of recurrence after surgical removal of PHO is very high [6,9]. Various treatments have been proposed to prevent the recurrence of PHO after resection, such as diphosphonates [13,20], postoperative local irradiation [2,4], insertion of free-fat autografts [1,14], or nonsteroid anti-inflammatory drugs (NSAIDs) [9,15].…”

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confidence: 99%

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Nonsteroid anti-inflammatory drugs prevent the recurrence of heterotopic ossification after excision

Sodemann

Persson

Nilsson

1990

Arch Orthop Trauma Surg

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The prophylactic effect of nonsteroid anti-inflammatory drugs on the recurrence of high-grade periarticular heterotopic ossification after resection was studied in ten patients operated on for loosening of one or both components of a cemented total hip prosthesis. These drugs, given at a standard dosage for 1-3 weeks after surgery, prevented the recurrence of heterotopic ossification. In some patients the range of motion of their joint increased following surgery, while it remained unaffected in the majority. At follow-up 2-5 years after surgery, all patients walked well and there were no clinical or radiographs signs of loosening of the prosthetic components. It is concluded that treatment with NSAIDs following resection of periarticular heterotopic ossification prevents recurrence.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Nonsteroid anti-inflammatory drugs prevent the recurrence of heterotopic ossification after excision

Sodemann

Persson

Nilsson

1990

Arch Orthop Trauma Surg

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“…NSA P: In allen Stu dien, auch in experimentellen Modellen (51), wird die Wirk samkei t von NSAP positiv beurteilt. Das Prophylaxe-Schema ist bei allen Au toren ann äh ernd identisc h: Indomethacin 3 x 25 mg (17,21 ,26, 32,39,40,44), auch 2 x50 mg (45, 46) ode r lbuprofen 3 x 400 mg (14, 45, 46) und auch Aspirin (37) über einen Zeitra um von in der Regel 6 Wochen (21,26,32,39,40,44) Strahlentherapie: Zeitpunkt der Bestr ahlung: Experimentell konnte bei Ratten gezeigt werden, daß eine einmalige Bestrahlung I Stunde pr ä-operati v denselben Effekt hat wie 2 Tage post-OP, da gegen fanden sich nach einer Bestrahlung 2 Tage prä-OP signifika nt mehr h. O . (19).…”

Section: Ergebnisseunclassified

Strahlentherapie zur Prophylaxe von periartikulären, heterotopen Ossifikationen nach Implantation von Hüfttotalendoprothesen

Goldmann

Seegenschmiedt²,

Andreas³

et al. 2008

Z Orthop Ihre Grenzgeb

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From June 1988 to January 1991 the efficacy of a low-dose (5 x 2 Gy) versus a high-dose (10 x 2 Gy, resp. 5 x 3,5 Gy) prophylactic postoperative radiotherapy was assessed in a prospective randomized trial. 60 patients at the highest risk for formation of heterotopic ossification (HO) were included in this study, i.e. patients that presented already HO in the ipsi- or contralateral hip at the time of surgery. After both irradiation regimen the incidence and severity of HO was significantly less than without prophylaxis; there was no significant difference (regarding the severity of HO, the hip score (16) and the hip mobility) between the two regimen.

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“…De nombreuses tentatives ont 6t6 fakes dans ce but, utilisant en particulier la radiotherapie [2,10,27,30,38], la prednisolone, ou l'indomethacine [13,21,33,34], et l'6thane-hydroxy-diphosphonate [3,14,37]. Ces divers moyens se sont averes relativement efficaces, mais non sans inconvenients ni sans effets indesirables.…”

Section: Introductionunclassified

Effet d'un inhibiteur calcique, le v�rapamil, sur le d�veloppement des ossifications h�t�rotopiques

Duriez

Flautre

Blary

et al. 1990

International Orthopaedics

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After division of the tendo achilles in rats heterotopic bone forms in the muscle and in the tendon stumps. Tenotomy was performed in 26 male rats. Thirteen received Verapamil (36 mm/Kg) for six days per week for five months, and the remainder were not given this drug. The onset of heterotopic ossification was monitored by monthly x-rays. After five months the animals were killed and the sectioned tendons examined microscopically. The radiographs had shown that the amount of ossification was less in rats treated with Verapamil. This was confirmed at microscopy, but examination of the sections under polarised light showed that the ratio of lamellar to woven bone was the same in the two groups. Verapamil appeared to reduce the amount of heterotopic bone formation but did not influence the substitution of woven by lamellar bone.

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Indomethacin for prevention of ectopic ossification after hip arthroplasty

Cited by 60 publications

References 18 publications

Nonsteroid anti-inflammatory drugs prevent the recurrence of heterotopic ossification after excision

Nonsteroid anti-inflammatory drugs prevent the recurrence of heterotopic ossification after excision

Strahlentherapie zur Prophylaxe von periartikulären, heterotopen Ossifikationen nach Implantation von Hüfttotalendoprothesen

Effet d'un inhibiteur calcique, le v�rapamil, sur le d�veloppement des ossifications h�t�rotopiques

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