2021
DOI: 10.1007/s40495-021-00257-6
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Indomethacin: Can It Counteract Bradykinin Effects in COVID-19 Patients?

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Cited by 18 publications
(14 citation statements)
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References 46 publications
(31 reference statements)
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“…Alkotaji et al 29 had hypothesised the importance of indomethacin in reducing cough and myalgia through its inhibitive action on bradykinin, and the mechanism and ill-effects of bradykinin are well documented. The theory proposed in this study explains the difference in symptomatic relief between the two groups.…”
Section: Discussionmentioning
confidence: 99%
“…Alkotaji et al 29 had hypothesised the importance of indomethacin in reducing cough and myalgia through its inhibitive action on bradykinin, and the mechanism and ill-effects of bradykinin are well documented. The theory proposed in this study explains the difference in symptomatic relief between the two groups.…”
Section: Discussionmentioning
confidence: 99%
“…The importance of indomethacin in reducing cough and myalgia through its inhibitive action of bradykinin has been hypothesised by Alkotaji et.al [28] and the mechanism and the ill-effects of bradykinin are well documented. The theory proposed in this reference explains the difference in symptomatic relief between the two groups.…”
Section: Discussionmentioning
confidence: 99%
“…Although no conclusive evidence is available for or against the use of NSAIDs, observational studies suggest that the use of selective COX-2 inhibitors, together with other drugs, can reduce the frequency of hospitalization, although it does not reduce the duration of symptoms [ 3 ]. In particular, indomethacin is an old and inexpensive anti-inflammatory drug used for headache and arthritis [ 77 , 78 ], and it can combat cough [ 79 , 80 ], which is a major cause of the spread of infection.…”
Section: Indomethacin As a Promising Nsaidmentioning
confidence: 99%
“…A recent network pharmacology approach identified 3 target proteins associated with the renin-angiotensin system imbalance caused by SARS-CoV-2 (MAPK8, MAPK10, and BAD) and showed that indomethacin can reduce excessive inflammation by inactivating target proteins [ 22 ]. It has also been hypothesized that indomethacin can counteract the proinflammatory effects of bradykinin, thus reducing the COVID-19-induced symptoms induced by bradykinin network activation, such as dry cough and musculoskeletal pains [ 80 ]. It has also been shown that indomethacin together with resveratrol can improve the disease [ 81 ].…”
Section: Indomethacin As a Promising Nsaidmentioning
confidence: 99%
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