Indomethacin and paracetamol: Interaction with prostaglandin synthesis in the rat stomach

Kolfschoten, A. A. van; Hagelen, F.; Noordwijk, J. van

doi:10.1016/0014-2999(82)90168-6

Cited by 11 publications

(6 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Paracetamol inhibits the ex vivo production of PGE 2 from mouse brain cells [47]. It also stimulated the production of PGs in the rat stomach [48], but did not reduce urinary excretion of PGE 2 [49]. Mean paracetamol consumption did not differ significantly between the two groups, which may reduce the effect of paracetamol in our study.…”

Section: Discussionmentioning

confidence: 53%

See 1 more Smart Citation

Endoscopic Comparison of the Gastroduodenal Safety and the Effects on Arachidonic Acid Products between Meloxicam and Piroxicam in the Treatment of Osteoarthritis

et al. 2001

View full text Add to dashboard Cite

Our objective was to evaluate the efficacy, the gastroduodenal safety, and the effects on arachidonic acid products of meloxicam, a new acidic enolic non-steroidal anti-inflammatory drug which preferentially inhibits cyclo-oxygenase-2 over cyclo-oxygenase-1, versus piroxicam in patients with osteoarthritis of the knee. Meloxicam 7.5 mg or piroxicam 20 mg daily was administered for 4 weeks in this double-blind parallel-groups randomised study. The efficacy for pain relief of the two tested medications was assessed by means of visual analogue scale and other clinical parameters. Pre- and post-treatment endoscopies were performed, and the findings were scored and recorded. The gastric fluid was aspirated at each time and prostaglandin E2, thromboxane B2 and leukotriene B4 were determined by ELISA. There was no significant difference between the groups regarding the primary efficacy. Changes in endoscopic findings by means of Lanza score showed statistically significant differences between the two treatment groups in favour of meloxicam at all sites--gastric, duodenal and total. Within-group comparisons showed a statistically significant difference (worsening) in gastric and total score with piroxicam, but no significant difference with meloxicam. The frequency of clinically relevant cases (total score >2) also showed a statistically significant worsening in the piroxicam group. The better GI tolerability of meloxicam was also suggested by fewer adverse GI events and no withdrawals due to adverse events compared with piroxicam. The pre-/post-study gastric juice concentration of PGE2, TXB2, and LTB4 in the meloxicam group was 135.2 +/- 85.8/71.2 +/- 32.2, 116.3 +/- 81.7/99.4 +/- 107.5 and 388 +/- 321/223 +/- 98 pg/ml respectively. The pre-/post-study gastric juice concentration of PGE2, TXB2 and LTB4 in the piroxicam group was 105.7 +/- 43.1/68.2 +/- 34.9, 94.0 +/- 50.9/105.9 +/- 121.1 and 625 +/- 1574/828 +/- 1464 pg/ml, respectively. Both meloxicam and piroxicam significantly inhibited gastric PGE2 levels after 4 weeks' treatment; however, there was no difference between these two groups. Neither of these medications had an effect on TXB2. Only meloxicam inhibited LTB4 concentration significantly, and the between-groups difference was significant. Meloxicam 7.5 mg once daily had better gastrointestinal tolerability and an efficacy comparable to that of piroxicam 20 mg over 4 weeks in patients with osteoarthritis of the knee.

show abstract

Section: Discussionmentioning

confidence: 53%

“…The effect of paracetamol on PG biosynthesis is variable [47][48][49]. Paracetamol inhibits the ex vivo production of PGE 2 from mouse brain cells [47].…”

Section: Discussionmentioning

confidence: 99%

Endoscopic Comparison of the Gastroduodenal Safety and the Effects on Arachidonic Acid Products between Meloxicam and Piroxicam in the Treatment of Osteoarthritis

et al. 2001

View full text Add to dashboard Cite

show abstract

“…In con trast to nonsteroidal anti-inflammatory drugs (NSAIDs), a previous study has shown that acetaminophen does not induce serious gastrointestinal damage in man [1], In addition, administration of a high dose of acetamino phen (orally or intraperitoneally) has been reported to exhibit a protective effect on gas tric mucosa against various irritants, such as NSAIDs, ethanol and stress [2][3][4], It has been stated that acetaminophen may stimulate prostaglandin Ea (PGE2) synthesis to protect gastric mucosa [5], On the contrary, some reports have suggested that protection by acetaminophen was not attributable to the stimulation of PG synthesis but due to an increase in mucus secretion [3] or to a direct effect on gastric mucosal cells [6], Other studies have reported acetamino phen to possess direct antioxidant actions against free-radical-induced oxidative stress in vitro [7][8][9][10], but it remains to be shown if the in vivo gastric protective effect of acet aminophen is due to its antioxidant effect. Superoxide radicals or hydroxyl radicals have been reported to play important roles in the pathogenesis of gastric erosions induced by ischemia-reperfusion in rats [11][12][13][14], There fore, using this model of acute gastric mucosal injury, we studied whether or not the protec tive effect of acetaminophen against ischemia-reperfusion-induced gastric injury is due to antioxidant or radical scavenging ac tions in vivo.…”

Section: Introductionmentioning

confidence: 99%

Protective Effect of Acetaminophen against Acute Gastric Mucosal Lesions Induced by Ischemia-Reperf usion in the Rat

Nakamoto

Kamisaki²,

Wada³

et al. 1997

Pharmacology

View full text Add to dashboard Cite

We examined the effect of acetaminophen, an analgesic and antipyretic drug, on acute gastric mucosal injury induced by ischemia-reperfusion in rats. Ischemia-reperfusion was induced by clamping the celiac artery for 30 min with a small clip. Sixty minutes after repefusion, the total area of erosions was measured. Acetaminophen (300 and 500 mg/kg) administered intraperitoneally 90 min before the ischemia significantly reduced the total area of erosions. The drug also inhibited the increase in lipid peroxide levels induced by ischemia-reperfusion in the gastric tissue and the increase in lipid peroxidation caused by the hydroxyl radical, OH^·, in vitro. Gastric prostaglandin E₂ (PGE₂) contents tended to increase after ischemia-reperfusion in both control and acetaminophen-treated groups. A significant difference in gastric PGE2 contents between control and acetaminophen-treated groups was not observed. The results indicate that acetaminophen may protect the gastric mucosa against ischemia-reperfusion injury, probably by blocking hydroxyl-radical-induced membrane damage.

show abstract

“…Previous studies indicate that low levels of acetaminophen exposure increase PG synthesis in rats (van Kolfschoten et al, 1981(van Kolfschoten et al, , 1982Boughton-Smith and Whittle, 1983;Danon et al, 1983), facilitating ovulation (Tsafriri et al, 1972;Clark et al, 1978;Ando et al, 1999) and implantation (Hurst and MacFarlane, 1981;Agrawal and Alvin Jose, 2009). Studies of urinary acetaminophen concentrations in women found no association with fecundability (Smarr et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

“…The most commonly used non-NSAID pain-reliever among US women during the preconception period is acetaminophen (Werler et al, 2005), which has potent analgesic effects but limited antiinflammatory effects (Botting, 2000). Compared with NSAIDs, acetaminophen has weak and varying effects on PG synthesis, with high levels of exposure inhibiting synthesis, and low levels of exposure stimulating synthesis (van Kolfschoten et al, 1981(van Kolfschoten et al, , 1982Boughton-Smith and Whittle, 1983;Danon et al, 1983). In humans, acetaminophen has been shown to slightly reduce the odds of anovulatory cycles (Matyas et al, 2015) and have little effect on female fecundability (Smarr et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Preconception use of pain-relievers and time-to-pregnancy: a prospective cohort study

et al. 2016

View full text Add to dashboard Cite

show abstract

Indomethacin and paracetamol: Interaction with prostaglandin synthesis in the rat stomach

Cited by 11 publications

References 7 publications

Endoscopic Comparison of the Gastroduodenal Safety and the Effects on Arachidonic Acid Products between Meloxicam and Piroxicam in the Treatment of Osteoarthritis

Endoscopic Comparison of the Gastroduodenal Safety and the Effects on Arachidonic Acid Products between Meloxicam and Piroxicam in the Treatment of Osteoarthritis

Protective Effect of Acetaminophen against Acute Gastric Mucosal Lesions Induced by Ischemia-Reperf usion in the Rat

Preconception use of pain-relievers and time-to-pregnancy: a prospective cohort study

Contact Info

Product

Resources

About