Indolylboronic Acids: Preparation and Applications

Abstract

Indole derivatives are associated with a variety of both biological activities and applications in the field of material chemistry. A number of different strategies for synthesizing substituted indoles by means of the reactions of indolylboronic acids with electrophilic compounds are considered the methods of choice for modifying indoles because indolylboronic acids are easily available, stable, non-toxic and new reactions using indolylboronic acids have been described in the literature. Thus, the aim of this review is to summarize the methods available for the preparation of indolylboronic acids as well as their chemical transformations. The review covers the period 2010–2019.

Recent Progress Concerning the N-Arylation of Indoles

“…An example of such a compound is sertindole, which is used as an antipsychotic drug [ 3 ]. Due to the significant biological activity of the indole derivatives, much attention has been paid to the modification of the indole unit [ 4 , 5 , 6 , 7 , 8 ].…”

Organophosphates as Versatile Substrates in Organic Synthesis

“…Beyond the realm of traditional methods, techniques involving transition-metal complexes [ 5 , 6 , 7 ], electrosynthesis [ 8 , 9 , 10 , 11 , 12 ], and photochemical transformations [ 13 , 14 , 15 ] are widely used. These developments have allowed for the preparation of a wide range of compounds as well as transformations that include the formation of C–C bonds [ 16 , 17 , 18 , 19 , 20 , 21 ], the synthesis of heterocyclic compounds [ 22 , 23 , 24 , 25 , 26 , 27 , 28 ], and the preparation of tetrasubstituted alkenes [ 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 ]. In addition to conventional starting compounds, organophosphates are increasingly utilized in organic synthesis, likely due to their availability.…”