Indolizine Derivatives with Biological Activity IV: 3-(2-Aminoethyl)-2-methylindolizine, 3-(2-Aminoethyl)-2-methyl-5,6,7,8-tetrahydroindolizine, and Their N-Alkyl Derivatives

Chemical constituents in n-butanol fractions of Costus afer ker Gawl leaf and stem

“…Indolizine found only in n -butanol fraction of C. afer leaves is an organic compound containing two condensed rings (5- and 6-membered) and a nitrogen atom junction [ 32 ]. Indolizine possesses biological activities such as anti-inflammatory [ 33 ], hypoglycemic activities [ 34 ], 5HT3 receptor antagonist [ 35 ], anti-acetylcholine [ 36 ], central nervous system depressant activity [ 37 ], estrogen receptor binding [ 38 ] antioxidant property [ 39 ], antimicrobial and analgesic activity [ 40 ], many aminoacid derivatives with an active indolizine nucleus have been utilized in cancer therapy [ 41 ]. Benzofuran, 2,3-dihydro is a coumaran and research has shown that it possesses anti-inflammatory, antidiarrheal and anti-helminthic activities [ 25 ].…”

Multicomponent Strategy to Pyrazolo[3,4-e]indolizine Derivatives under Microwave Irradiation

“…Yellow solid, 0.199g, yield 78%; mp 247-249 °C ; IR (KBr, ν, cm -1 ) 2924,2850,1687,1668,1572,1493,1453,1362,1289,1256,1223,1166,1040,984,866,844,777 8, 137.7, 137.2, 136.0, 135.8, 133.7, 130.2, 129.9, 129.5, 129.0, 128.8, 127.9, 127.4, 127.1, 120.6, 117.1, 111.5, 106.7, 56.6, 35.4, 30.1, 13.7 -9-phenyl-3,4-dihydropyrazolo[3,4-b] -9-phenyl-3,4-dihydropyrazolo[3,4-b] 7, (100 MHz,CDCl 3 ,δ,ppm) 196.3,195.1,150.6,137.8,137.1,135.8,133.0,131.3,130.3,130.1,130.0,129.7,129.5,129.3,128.8,128.7,128.2,127.9,127.7,127.4,127.2,125.9,121.0,118.2,111.8,106.6,56.8,35.4,30. -7,9-diphenyl-3,4-dihydropyrazolo[3,4 -b] 3,3-Dimethyl-6-(4-methylbenzoyl) -7,9-diphenyl-2-(p-tolyl)-3,4-dihydropyrazolo[3,4-b]…”

Greener synthesis of indolizine analogues using water as a base and solvent: study for larvicidal activity against Anopheles arabiensis

“…The 1‐azabicyclo[4,3,0]nonane (indolizine) framework occupies a special place in heterocyclic systems due to the presence of this structural assembly in a number of natural products of biological importance such as tabersonine, (−)‐strychnine, (+)‐vinblastine, (−)‐monomorine, and (−)‐gephyrotoxin . On the other hand, synthetic indolizine derivatives have been reported as calcium channel blockers, phospholipase A 2 inhibitors, histamine H 3 ‐receptors antagonist, 5‐HT 3 ‐receptors antagonists, anti‐inflammatory, antitumor agents, and oral hypoglycemic and CNS activity . In continuation of our studies on synthesis of promising heterocyclic compounds for anti‐TB, anticancer, and antimosquito properties and screening them for polymorphism behavior, herewith, we undertake design and synthesis of novel indolizine scaffolds (Scheme 1) to be screened for larvicidal activity against Anopheles arabiensis by standard WHO larvicidal assay using standard substance…”