Indolizidine and quinolizidine alkaloids

Transition Metal‐Catalyzed Synthesis of Fused Five‐Membered Aromatic Heterocycles

“…The diverse pharmacological potential of indolizines and related derivatives stimulates a continuous interest in utilizing molecules containing this core in synthetic biologically active compounds [279][280][281][282][283][284][285][286][287]. Furthermore, indolizines, due to their intriguing molecular properties, found applications in the field of material science and in a range of artificial materials [279,280].…”

Asymmetric Synthesis of Ring Functionalizedtrans-2,6-Disubstituted Piperidines fromN-Sulfinyl δ-Amino β-Keto Phosphonates. Total Synthesis of (−)-Myrtine

“…Polyhydroxylated piperidines (azasugars) are potent inhibitors of carbohydrate-processing enzymes, which suggests they will find utility in treating viral infections, cancer, diabetes, and tuberculosis . Furthermore, piperidines serve as building blocks for the synthesis of more complex alkaloids, including the indolizidine and quinolizidine ring systems, which in themselves exhibit a broad range of biological activities , Unfortunately, most of these procedures lack generality, are racemic,7c or target specific syntheses. 7d-n Few of these methods provide convenient access to enantiopure ring functionalized examples, with the majority of these being target-specific .…”

SmI2-Mediated Couplings of α-Amino Acid Derivatives. Formal Synthesis of (−)-Pumiliotoxin 251D and (±)-Epiquinamide

“…Among them, indolizidine, quinolizidine, and piperidine alkaloids play an important role due to their interesting framework and biological activities. These compounds are very widespread in nature and are found in a myriad of organisms . Although the literature describes plenty of methods to prepare these heterocyclic systems, short, direct, and diversity-oriented approaches are scarce.…”