Indoles in Multicomponent Processes (MCPs)

Shiri, Morteza

doi:10.1021/cr2003954

Cited by 736 publications

(167 citation statements)

References 341 publications

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“…Indole scaffolds have been known for their value in the development of new compounds of pharmaceutical interest. [18][19][20] Up to date, several 21,22 Herein, in continuation of our studies towards the synthesis of heterocyclic compounds and multicomponent reactions, [23][24][25][26][27][28][29][30][31][32] and since there is a wide range of reactions that include indole in the preparation of heterocyclic compounds, this review presents the recent applications of indole in the synthesis of diverse heterocyclic compounds during the period from 2012 to 2017. This review rst discusses indoles' C-3 carbon atom reactivity applicable to electrophilic reactions, followed by MCRs in which the N position of indole is reacted as a nucleophile to afford N-substituted indole products.…”

Section: Introductionmentioning

confidence: 99%

Recent advances in the application of indoles in multicomponent reactions

2018

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Indoles are some of the most versatile and common nitrogen-based heterocyclic scaffolds and are frequently used in the synthesis of various organic compounds. Indole based compounds are very important among heterocyclic structures due to their biological and pharmaceutical activities. The last decade, in particular, has witnessed considerable activity towards the synthesis of indole derivatives due to the possibilities for the design of polycyclic structures by the incorporation of multiple fused heterocyclic scaffolds in an attempt to achieve promising new heterocycles with chemical and biomedical relevance. In this study, we provide an overview on recent applications of indole in the multicomponent reactions for the synthesis of various heterocyclic compounds during the period of 2012 to 2017.

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Section: Introductionmentioning

confidence: 99%

Recent advances in the application of indoles in multicomponent reactions

2018

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“…[1] In this context, it is not surprising to note a beehive of activity in the development of sustainable methods for the synthesis [2] and functionalization [3] of the indolyl core. Over the past ten years, advances in catalysis have revolutionized the field by bringing unexpected levels of efficiency, selectivity, and sustainability into practice.…”

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confidence: 99%

One‐Pot Gold‐Catalyzed Synthesis of Azepino[1,2‐a]indoles

et al. 2012

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Als außergewöhnlich effektiver Katalysator für die Eintopfsynthese tricyclischer Azepinoindole in einer neuartigen Kaskadenreaktion erwies sich ein Komplex aus Gold(I) und einem N‐heterocyclischen Carben (IPr=1,3‐Di(isopropylphenyl)imidazol‐2‐yliden). Einfach verfügbare Substrate, hohe Chemoselektivität, gute Ausbeuten und Wasser als einziges stöchiometrisches Begleitprodukt sind einige der Hauptvorteile dieser Methode.

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“…Ethyl 3-(indol-3-yl) alkanoates were obtained by one-pot, three-component KnoevenagelMichael reaction of indoles, Meldrum's acid and various aldehydes followed by decarboxylative ethanolysis of the adducts obtained. [23][24][25][26] The other strategy is based on the conjugate addition of indoles to alkylidenemalonates. 6 Recently, urea palladecycles 27 and Sc(OTf) 3 36 Two efficient protocols for the synthesis of 3-unsubstituted-4-(indol-3-yl)-3,4-dihydrocoumarins have been reported.…”

Section: Introductionmentioning

confidence: 99%