Indoleamine 2,3-Dioxygenase 1 Inhibitor-Loaded Nanosheets Enhance CAR-T Cell Function in Esophageal Squamous Cell Carcinoma

Shao, Jingwen; Hou, Lin; Liu, Jinyan; Liu, Yulin; Ning, Jie; Zhao, Qitai; Zhang, Yi

doi:10.3389/fimmu.2021.661357

Cited by 17 publications

(9 citation statements)

References 46 publications

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“…These results suggest that DNAJC5B may be related to the function, activation state, and role in anti-tumor immune responses of CD8 + T cells. Moreover, this discovery offered crucial insights for the development of novel immunotherapeutic strategies for esophageal cancer, especially in terms of utilizing or targeting CD8 + T cells, consistent with the ndings of other researchers [23].…”

Section: Discussionsupporting

confidence: 84%

WITHDRAWN: Clinical characterization and immunosuppressive regulation of DNAJCB5B in Esophageal Squamous Cell Carcinoma

Hu,

Xu,

Tian

et al. 2024

Preprint

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Background DnaJ Homolog Subfamily C Member 5B (DNAJC5B), as a member of the heat shock protein family, has not yet been fully clarified in its role in tumor development, making it particularly important to study its potential role in the immunotherapy of esophageal cancer. Methods This study utilized the esophageal cancer dataset from the TCGA database, selecting genes associated with DNAJC5B expression through Pearson correlation analysis, followed by Gene Ontology (GO) functional enrichment analysis and KEGG pathway analysis. Additionally, single-cell RNA sequencing data was used to analyze DNAJC5B expression in different T cell subgroups. The prognostic value of DNAJC5B was evaluated using Kaplan-Meier survival curves, receiver operating characteristic (ROC) curves, and Cox proportional hazards model analysis. Results DNAJC5B is highly expressed in patients with advanced esophageal cancer, especially in males. Immunohistochemical staining results indicate a notable enrichment of DNAJC5B in the cytoplasm of cancer tissue cells. GO and KEGG analysis indicated significant correlations between DNAJC5B expression and immune-related processes like adaptive immune response and cell surface receptor signaling pathways. Single-cell analysis showed that DNAJC5B predominantly accumulates in CD8+ T cells and is associated with cell activation state. Survival analysis indicated that patients with high DNAJC5B expression had a median survival of 681 days, markedly lower than the 1361 days in those with low expression. Both univariate and multivariate Cox proportional hazards model analyses identified DNAJC5B as an independent prognostic factor in ESCC patients. Conclusion This study suggests that DNAJC5B may play a significant immunomodulatory role in esophageal cancer, particularly in regulating CD8+ T cell function and tumor immune escape. These findings support the potential of DNAJC5B as a biomarker for treatment and prognosis evaluation in esophageal cancer, providing new strategic directions for immunotherapy of esophageal cancer.

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Section: Discussionsupporting

confidence: 84%

WITHDRAWN: Clinical characterization and immunosuppressive regulation of DNAJCB5B in Esophageal Squamous Cell Carcinoma

Hu,

Xu,

Tian

et al. 2024

Preprint

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“…With the utilizing of epacadostat-loaded hyaluronic acid-modified nanomaterial graphene oxide (HA-GO) nanosheets, CAR-T cells exhibit a more powerful anti-tumor ability. [76] To overcome the immunosuppressive impact of TME with high concentrations of Kyn, Yang et al [77] have modified CAR-T cells through overexpression (OE) of KYUN. They found that KYUN-OE CAR-T cells showed a superior anti-tumor activity even in the immunosuppressive TME with high Kyn.…”

Section: Strategies For Improving the Effectiveness Of Car-t Cells By...mentioning

confidence: 99%

Targeting metabolism to improve CAR-T cells therapeutic efficacy

Liu,

Zhao,

Gao

et al. 2024

Chinese Medical Journal

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Chimeric antigen receptor T (CAR-T) cell therapy achieved advanced progress in the treatment of hematological tumors. However, the application of CAR-T cell therapy for solid tumors still faces many challenges. Competition with tumor cells for metabolic resources in an already nutrient-poor tumor microenvironment is a major contributing cause to CAR-T cell therapy’s low effectiveness. Abnormal metabolic processes are now acknowledged to shape the tumor microenvironment, which is characterized by increased interstitial fluid pressure, low pH level, hypoxia, accumulation of immunosuppressive metabolites, and mitochondrial dysfunction. These factors are important contributors to restriction of T cell proliferation, cytokine release, and suppression of tumor cell-killing ability. This review provides an overview of how different metabolites regulate T cell activity, analyzes the current dilemmas, and proposes key strategies to reestablish the CAR-T cell therapy’s effectiveness through targeting metabolism, with the aim of providing new strategies to surmount the obstacle in the way of solid tumor CAR-T cell treatment.

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“…Enhanced MUC1-CAR T cells have been shown to have better antitumor activity because they can survive longer in vivo , which means they have long-lasting antitumor effects ( 156 ). Also, it has been recently reported that IDO1 inhibitor-loaded nanosheets could enhance CAR T-cell effectiveness in ESCC and CD276 suppress CAR T-cell function ( 157 , 158 ). The selection of different solid tumor-specific antigens and the delivery of CAR T cells are still the disadvantages of CAR T-cell therapy ( 159 ).…”

Section: Targeting Tumor Microenvironment For Esophageal Squamous Cel...mentioning

confidence: 99%

The Role of Tumor Microenvironment in Invasion and Metastasis of Esophageal Squamous Cell Carcinoma

2022

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Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers in the world, with a high rate of morbidity. The invasion and metastasis of ESCC is the main reason for high mortality. More and more evidence suggests that metastasized cancer cells require cellular elements that contribute to ESCC tumor microenvironment (TME) formation. TME contains many immune cells and stromal components, which are critical to epithelial–mesenchymal transition, immune escape, angiogenesis/lymphangiogenesis, metastasis niche formation, and invasion/metastasis. In this review, we will focus on the mechanism of different microenvironment cellular elements in ESCC invasion and metastasis and discuss recent therapeutic attempts to restore the tumor-suppressing function of cells within the TME. It will represent the whole picture of TME in the metastasis and invasion process of ESCC.

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Indoleamine 2,3-Dioxygenase 1 Inhibitor-Loaded Nanosheets Enhance CAR-T Cell Function in Esophageal Squamous Cell Carcinoma

Cited by 17 publications

References 46 publications

WITHDRAWN: Clinical characterization and immunosuppressive regulation of DNAJCB5B in Esophageal Squamous Cell Carcinoma

WITHDRAWN: Clinical characterization and immunosuppressive regulation of DNAJCB5B in Esophageal Squamous Cell Carcinoma

Targeting metabolism to improve CAR-T cells therapeutic efficacy

The Role of Tumor Microenvironment in Invasion and Metastasis of Esophageal Squamous Cell Carcinoma

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