Indole derivatives inhibited the formation of bacterial biofilm and modulated Ca2+ efflux in diatom

Yang, Cuiyun; Yin, Yu; Sun, Wei; Chen, Xia

doi:10.1016/j.marpolbul.2014.09.027

Cited by 32 publications

(12 citation statements)

References 37 publications

(42 reference statements)

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“…Our results do not coincide with the findings of Yang et al [22], because the 5-bromo indole showed more anti-algal activity that gramine. Therefore, further research is necessary to fully clarify the anti-algal mechanism of these compounds.…”

Section: Anti-algal Activitycontrasting

confidence: 99%

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Chemical Basis for the Phytotoxicity of Indoles in Relation to the Allelopathy of Cereals

Bravo¹,

Copaja²

2018

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Phytotoxic activity of an indole series substituted with electron-acceptor and electron-donor groups in the aromatic ring was determined. They are potential decomposition products, of natural indole alkaloids in cereals plants with allelopathic properties. Phytotoxic selectivity was evaluated from antialgal activity against the microalga Chlorella vulgaris, seed germination seeds and biomass weight of seedling of barley, rye, wheat, oat and maize species and the weed Lolium rigidum. Lipophilia character of the compounds was determined by RP-HPLC method. Both, the electronic character of the substituents, evaluated from σ p parameter, and the lipophilia character of the molecules measured from logP HPLC parameter, are involved in the phytotoxic activity. The three bio indicators has shown that the compounds with the higher electron-acceptor groups showed the higher level of phytotoxicity and the molecules with electron-donor groups showed the lowest activity, although, in some cases, this behavior is modified by the lipophilic properties of the molecules. These results are rationalized in terms of polarization of N-H bond of heterocyclic ring. Compounds with the higher logP HPLC values showed the higher phytotoxic activity. Further evidence on the role of lipophilicity was obtained from linear regression between the average inhibitions percentages of biomass and logP HPLC values. The activity increased linearly by increasing the lipophilic character of the compounds. Therefore, quantitative effects in the phytotoxic activity of the electronic properties of the substituents in the aromatic ring and lipophilic character of the indoles can be inferred from σ p and logP HPLC parameters, respectively. The results strongly suggest that the potential decomposition products of the natural indole alkaloids from cereals or other natural sources may be in connection with the allelopathic phenomenon of plants when are released into the soil.

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Section: Anti-algal Activitycontrasting

confidence: 99%

“…Cellular Ca 2+ efflux in algae has been proposed as one of the possible mechanisms that inhibits the growth of the algae Cylindrotheca sp and other bioactivity of indole and gramine [22]. Their results showed that gramine had more anti-algal activity than indoles substituted with halogen atoms in the aromatic ring.…”

Section: Anti-algal Activitymentioning

confidence: 99%

Chemical Basis for the Phytotoxicity of Indoles in Relation to the Allelopathy of Cereals

Bravo¹,

Copaja²

2018

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“…For example, plant-derived indolylacetonitrile reduces virulence factor production in P. aeruginosa, in which the compound is stable [42], indolylacetonitrile reduces the virulence of C. albicans more effectively than indole [56], 7-benzyloxyindole attenuates the virulence of S. aureus more than indole [57], and 6-chloroindole inhibits the growth of, and biofilm formation by, algal Cylindrotheca sp. by inducing Ca 2+ efflux [66].…”

Section: Antivirulence Activities Of Indoles Against Non-indole-produmentioning

confidence: 99%

Roles of Indole as an Interspecies and Interkingdom Signaling Molecule

Lee

Wood

2015

Trends in Microbiology

408

298

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“…In the current investigation, melatonin was found to have inhibitory effects on Xoc in a dose-dependent manner. In previous research, it was observed that indole and its derivatives have an antibacterial effect (Raut et al, 2012;Yang et al, 2014). Therefore, the inhibitory effect of melatonin may be due to the indole in its structure.…”

Section: Discussionmentioning

confidence: 97%

Melatonin treatments reduce the pathogenicity and inhibit the growth of Xanthomonas oryzae pv. oryzicola

et al. 2018

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Rice bacterial leaf streak (BLS), caused by Xanthomonas oryzae pv. oryzicola (Xoc), is a prevalent disease worldwide. Melatonin, an indoleamine with the chemical name N‐acetyl‐5‐methoxytryptamine, is known to inhibit the growth of human pathogenic bacteria. However, the impact of melatonin on agricultural pathogenic bacteria remains poorly understood. In this study, the effect of melatonin on Xoc was investigated. Exogenous melatonin (200 μg mL−1) significantly inhibited the growth of Xoc and reduced the mRNA expression level of seven cell division‐related genes. Melatonin reduced the pathogenicity of Xoc towards the susceptible rice IR24. The lesion length in IR24 infected by Xoc pretreated with melatonin (200 μg mL−1) was more than 23% smaller than the lesion length of the control group. Similarly, infection of IR24 leaves by Xoc pretreated with melatonin (200 μg mL−1) reduced the bacterial population by 45%. The biofilm formation, swimming motility and extracellular protease activities of Xoc also decreased under melatonin treatment. Melatonin only slightly changed the morphology of Xoc but significantly reduced the mRNA expression of toxin genes. Furthermore, treating leaves with exogenous melatonin reduced the incidence of BLS by 17%. It is reported for the first time that melatonin reduces pathogenicity and may serve as a bactericide for controlling BLS disease.

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Indole derivatives inhibited the formation of bacterial biofilm and modulated Ca2+ efflux in diatom

Cited by 32 publications

References 37 publications

Chemical Basis for the Phytotoxicity of Indoles in Relation to the Allelopathy of Cereals

Chemical Basis for the Phytotoxicity of Indoles in Relation to the Allelopathy of Cereals

Roles of Indole as an Interspecies and Interkingdom Signaling Molecule

Melatonin treatments reduce the pathogenicity and inhibit the growth of Xanthomonas oryzae pv. oryzicola

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