Indole clubbed 2,4‐thiazolidinedione linked 1,2,3‐triazole as a potent antimalarial and antibacterial agent against drug‐resistant strain and molecular modeling studies
Dipti B. Upadhyay,
Jaydeep A. Mokariya,
Paras J. Patel
et al.
Abstract:In the face of escalating challenges of microbial resistance strains, this study describes the design and synthesis of 5‐({1‐[(1H‐1,2,3‐triazol‐4‐yl)methyl]‐1H‐indol‐3‐yl}methylene)thiazolidine‐2,4‐dione derivatives, which have demonstrated significant antimicrobial properties. Compared with the minimum inhibitory concentrations (MIC) values of ciprofloxacin on the respective strains, compounds 5a, 5d, 5g, 5l, and 5m exhibited potent antibacterial activity with MIC values ranging from 16 to 25 µM. Almost all t… Show more
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