Indole-Bearing Azo Compounds: Molecular Docking and in silico ADMET Analysis
Ömer Dilek,
Tahir Tilki,
Çiğdem Karabacak Atay
Abstract:In this study, the interaction between the 12 indole-bearing azo compounds (a-l), which were previously synthesized by our research group, and two proteins, 2XIR and 5TGZ, was investigated using an in silico method. The ligand-protein interaction parameters and quantities were determined via molecular docking simulation studies. Since compound e has the lowest docking scores for both 2XIR and 5TGZ, it was selected for additional research on binding interactions. Both e-2XIR and e-5TGZ had docking scores that w… Show more
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