Indole- and indolizine-glyoxylamides displaying cytotoxicity against multidrug resistant cancer cell lines

Metal-organic framework MIL-53(Al): synthesis, catalytic performance for the Friedel-Crafts acylation, and reaction mechanism

“…Heterocyclic aromatic ketones are important organic intermediates in the synthesis of fine chemicals, which are mainly used as medicines and in prepared spices and agricultural chemicals. Some of these chemicals also have biological activity [2]. Indole and indole derivatives are the most heterocyclic aromatic compounds found in nature.…”

Some electrophilic reactivity studies of di-(2-indolyl)dibenzofurans and di-(2-indolyl)carbazoles

“…15 Alkaloids containing the indole-glyoxylamide moiety have been shown to act as selective ligands at peripheral benzodiazepine receptor sites, 16 and to show in vitro cytotoxicity against a range of cancer cell lines. 17 The reaction of 3,6-di-(2-indolyl)-dibenzofuran 1 with oxalyl chloride in anhydrous diethyl ether at room temperature gave the corresponding bis-glyoxylic acid chloride 35 in 80% yield as a brown solid (Scheme 4). The 1 H NMR spectrum of the bisglyoxylic acid chloride 35 showed the disappearance of the indole H3 and H3 0 protons at 6.96 ppm, and the 13 C NMR spectrum showed two carbonyl resonances at 167.2 and 184.8 ppm.…”

Design and Synthesis of Novel Indolizine Analogues as COX-2 Inhibitors: Computational Perspective and in vitro Screening

“…[8][9][10][11][12][13][14][15][16][17][18] Accordingly, synthesis and derivatization of indolizines have attracted considerable attention of medicinal chemist over the decades. [19][20][21][22][23][24][25][26][27][28][29][30][31][32][33] Particularly the 3-benzoylindolizines are attractive since their derivatives have been used as pharmacologically interesting compounds and their vital role as the synthetic intermediates for 3-substituted indolizines is also apparent.…”