Indole alkaloids in medicine

Ban, Yoshio; Murakami, Yasuoki; Iwasawa, Yoshio; Tsuchiya, Masamitsu; Takano, Noriko

doi:10.1002/med.2610080205

Cited by 66 publications

(33 citation statements)

References 202 publications

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“…The rats were killed 2 h after day 5 of feeding. The heparinized blood was deproteinized (Somogyi, 1945). Sugar was estimated by the anthrone method (Roe, 1955…”

Section: Methodsmentioning

confidence: 99%

Catharanthus roseus cell cultures: Growth, alkaloid synthesis and antidiabetic activity

Benjamin

Kelkar

Pote

et al. 1994

Phytotherapy Research

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“…The rats were killed 2 h after day 5 of feeding. The heparinized blood was deproteinized (Somogyi, 1945). Sugar was estimated by the anthrone method (Roe, 1955…”

Section: Methodsmentioning

confidence: 99%

Catharanthus roseus cell cultures: Growth, alkaloid synthesis and antidiabetic activity

Benjamin

Kelkar

Pote

et al. 1994

Phytotherapy Research

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“…In the original description of the action of alkaloids in Narcissus, the fl owering bulb was associated with anticholinergic -type effects and the nonfl owering one with cholinergic actions (Ringer and Morshead 1879). Lycorine is also a centrally acting emetic and an inhibitor of protein synthesis in eukaryotic cells, by inhibition of peptide bond formation (Martin 1987;Ban et al 1988). There was only a quantitative difference between the two growth stages with the fl owering bulb about half as toxic.…”

Section: Distribution and Habitat-in Cool -Temperate Climatesmentioning

confidence: 99%

Liliaceae Juss.

2012

Toxic Plants of North America

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“…[23][24][25][26][27] Further, bacterial oxygenases can readily oxidize indole into various metabolites, such as isatin and isoindigo, that have also been shown to play a role in the control of biofilm formation via QS mechanisms. [23][24][25][26][27] Further, bacterial oxygenases can readily oxidize indole into various metabolites, such as isatin and isoindigo, that have also been shown to play a role in the control of biofilm formation via QS mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Indole-based novel small molecules for the modulation of bacterial signalling pathways

et al. 2015

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Gram-negative bacteria such as Pseudomonas aeruginosa use N-acylated L-homoserine lactones (AHLs) as autoinducers (AIs) for quorum sensing (QS), a major regulatory and cell-to-cell communication system for social adaptation, virulence factor production, biofilm formation and antibiotic resistance. Some bacteria use indole moieties for intercellular signaling and as regulators of various bacterial phenotypes important for evading the innate host immune response and antimicrobial resistance. A range of natural and synthetic indole derivatives have been found to act as inhibitors of QS-dependent bacterial phenotypes, complementing the bactericidal ability of traditional antibiotics. In this work, various indole-based AHL mimics were designed and synthesized via the 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide hydrochloride (EDC·HCl) and N,N'-dicyclohexylcarbodiimide (DCC) mediated coupling reactions of a variety of substituted or unsubstituted aminoindoles with different alkanoic acids. All synthesized compounds were tested for QS inhibition using a P. aeruginosa QS reporter strain by measuring the amount of green fluorescent protein (GFP) production. Docking studies were performed to examine their potential to bind and therefore inhibit the target QS receptor protein. The most potent compounds 11a, 11d and 16a showed 44 to 65% inhibition of QS activity at 250 μM concentration, and represent promising drug leads for the further development of anti-QS antimicrobial compounds.

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Indole alkaloids in medicine

Cited by 66 publications

References 202 publications

Catharanthus roseus cell cultures: Growth, alkaloid synthesis and antidiabetic activity

Catharanthus roseus cell cultures: Growth, alkaloid synthesis and antidiabetic activity

Liliaceae Juss.

Indole-based novel small molecules for the modulation of bacterial signalling pathways

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