Indole alkaloids from the Marquesan plant Rauvolfia nukuhivensis and their effects on ion channels

Martin, Nicolas J.; Ferreiro, Sara F.; Barbault, Florent; Nicolas, Maël; Lecellier, Gaêl; Paetz, Christian; Gaysinski, Marc; Albrecht, Eva; Thomas, Olivier P.; Botana, Luís M.; Raharivelomanana, Phila

doi:10.1016/j.phytochem.2014.10.026

Cited by 22 publications

(8 citation statements)

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“…Among these main fidelity levels, it is striking to note the presence of two Marquesan endemic plants ( Rauvolfia nukuhivensis and Santalum insulare var. marchionense ) among the six of Marquesan cosmetopoeia; this constitutes real originality and could lead to pertinent phytochemical studies as recently highlighted [25–27]. Regarding coconut oil, its omnipresence is related to its use as an excipient for fragrant preparations but also to its own virtues (active principle) in hydration for example.…”

Section: Resultsmentioning

confidence: 97%

Ethnobotanical survey of cosmetic plants used in Marquesas Islands (French Polynesia)

Jost¹,

Ansel²,

Lecellier³

et al. 2016

J Ethnobiology Ethnomedicine

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BackgroundCosmetic plants and their uses have often been neglected in ethnobotanical surveys which focus mainly on plants with medicinal or food uses. Thus, this survey was carried out to specifically investigate cosmetics in a small community and to establish a cosmetopoeia, based on the model of pharmacopoeia for medicinal plants. The geographic spread of the survey covered the Marquesas Islands, one of the five archipelagos of French Polynesia (Pacific Ocean). This archipelago was also recently investigated for its pharmacopoeia.MethodsThis survey is based on individual interviews of Marquesan informants on the islands of Tahiti (Society archipelago) and Nuku Hiva (Marquesas archipelago). The methodological approach was semi-directive with open-ended questions based on cosmetic criteria (application area, cosmetic use, plant). Before each interview, researchers and the informant signed a Prior Informed Consent (PIC). Quantitative analyses were performed using basic statistics and the indice of Fidelity Level (FL).ResultsTwenty-eight informants from five of the six inhabited Marquesan islands were interviewed and yielded more than 500 cosmetic recipes. Marquesan cosmetopoeia included 79 plant taxa, of which 5% are Marquesan endemics, 23% are indigenous, 28% are Polynesian introductions and 44% are modern introductions. Among the introduced species, half were cultivated whereas the other half were weedy species. Most of the plants were abundant and only eight species were considered rare, of which four were Marquesan endemics. Main cosmetic plants were identified through informant citations and fidelity levels, and included Calophyllum inophyllum, Cananga odorata, Citrus aurantiifolia, Cocos nucifera, Curcuma longa, Gardenia taitensis, Mentha spp., Ocimum basilicum, Rauvolfia nukuhivensis and Santalum insulare var. marchionense. The most referred application areas were skin, hair and private parts whereas the main cosmetic uses were perfume, hydration, medicinal care and healing.ConclusionsThrough this survey, Marquesan cosmetopoeia was investigated in detail and uncovered a majority of introduced and abundant plants, and a minority of endemic and rare plants which required proper management to avoid future shortage. The well known perfumed coconut oil or monoi appeared as the main Marquesan cosmetic preparation either for the skin and the hair. Several plants and preparations warrant scientific investigations for their originality.

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Section: Resultsmentioning

confidence: 97%

Ethnobotanical survey of cosmetic plants used in Marquesas Islands (French Polynesia)

Jost¹,

Ansel²,

Lecellier³

et al. 2016

J Ethnobiology Ethnomedicine

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“…Five extracts strongly inhibited hERG currents (l " Table 1): C. ipecacuanha (Rubiaceae; roots and rhizomes, 32.5 %), Chelidonium majus L. (Papaveraceae; herb, 47.9 %), Cinchona pubescens (Rubiaceae; bark, 45.3 %), N. nucifera (Nelumbonaceae; leaves, 50.4 %), and Rauvolfia serpentina L. (Apocynaceae; roots, 39.1 %). All active extracts were obtained from alkaloid-rich plants and were previously reported to cause arrhythmias and/or contain hERG blocking constituents [7,19,20,[27][28][29][30][31]. For instance, aporphine- [7], isoquinoline- [30], and ajmaline-type [31] alkaloids present in the abovementioned extracts were shown to inhibit the hERG current in vitro and in vivo at a low micromolar range.…”

Section: Resultsmentioning

confidence: 99%

“…All active extracts were obtained from alkaloid-rich plants and were previously reported to cause arrhythmias and/or contain hERG blocking constituents [7,19,20,[27][28][29][30][31]. For instance, aporphine- [7], isoquinoline- [30], and ajmaline-type [31] alkaloids present in the abovementioned extracts were shown to inhibit the hERG current in vitro and in vivo at a low micromolar range. In this view, our screening results corroborate the cardiac liabilities previously described for these plants, and add affluence to the hERG-related cardiotoxicity monitoring of relevant botanicals.…”

Section: Resultsmentioning

confidence: 99%

hERG Channel Blocking Ipecac Alkaloids Identified by Combined In Silico – In Vitro Screening

et al. 2016

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Human ether-a-go-go-related gene channel blocking is associated with QT interval prolongation and increased risk of potentially fatal arrhythmias. As natural products keep increasing in popularity, there is an urgent need for studies assessing human ether-a-go-go-related gene channel-related cardiotoxic risks. We selected 49 plant species based on the results of a pharmacophore-based virtual screening campaign, in parallel with a literature data survey concerning highly consumed herbal medicines with reported cardiac liabilities. Lead-like enhanced extracts were prepared, an initial in vitro screening was performed at 100 µg/mL by voltage clamp on Xenopus oocytes, and five human ether-a-go-go-related gene channel blocking extracts were identified. In accordance to the six virtually predicted alkaloids, the root extract of Carapichea ipecacuanha inhibited human ether-a-go-go-related gene channel currents by 32.5 %. A phytochemical workflow resulted in the isolation and identification of five out of the six virtually predicted alkaloids. All isolates blocked human ether-a-go-go-related gene channel currents to different extents. The major ipecac constituents emetine (1) and cephaeline (2) showed IC50 values of 21.4 and 5.3 µM, respectively, measured by whole-cell patch clamp in HEK293 cells. This is the first report on human ether-a-go-go-related gene channel blockers from C. ipecacuanha. Its roots and rhizomes are used to produce different pharmacopeial ipecac preparations that are mainly used as emetics for poisoning treatment. Our findings raise further questions regarding the safety and over-the-counter appropriateness of these herbal products.

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“…These nitrogen-containing compounds occur in characteristic plant families such as Ranunculaceae, Papaveraceae, Berberidaceae, Apocynaceae, and Rubiaceae. 49 , 67 , 72 , 80 , 81 …”

Section: Herg Channel Blockers Of Natural Originmentioning

confidence: 99%

Natural products modulating the hERG channel: heartaches and hope

Kratz

Grienke

Scheel³

et al. 2017

Nat. Prod. Rep.

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Indole alkaloids from the Marquesan plant Rauvolfia nukuhivensis and their effects on ion channels

Cited by 22 publications

References 59 publications

Ethnobotanical survey of cosmetic plants used in Marquesas Islands (French Polynesia)

Ethnobotanical survey of cosmetic plants used in Marquesas Islands (French Polynesia)

hERG Channel Blocking Ipecac Alkaloids Identified by Combined In Silico – In Vitro Screening

Natural products modulating the hERG channel: heartaches and hope

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