Indole alkaloid sulfonic acids from an aqueous extract of Isatis indigotica roots and their antiviral activity

Abstract

Six new indole alkaloid sulfonic acids (1–6), together with two analogues (7 and 8) that were previously reported as synthetic products, were isolated from an aqueous extract of the Isatis indigotica root. Their structures including the absolute configurations were determined by spectroscopic data analysis, combined with enzyme hydrolysis and comparison of experimental circular dichroism and calculated electronic circular dichroism spectra. In the preliminary assay, compounds 2 and 4 showed antiviral activity against Coxsackie virus B3 and influenza virus A/Hanfang/359/95 (H3N2), respectively.

Untargeted liquid chromatography coupled with mass spectrometry reveals metabolic changes in nitrogen-deficient Isatis indigotica Fortune

“…Isatis indigotica Fortune (Brassicaceae) has long been used as a medicinal plant for the treatment of colds, fever, and influenza (Zhou and Zhang, 2013), especially for the treatment of severe acute respiratory syndrome (SARS) and H 1 N 1 -influenza (Jie et al, 2017;Lin et al, 2005). In previous studies, I.indigotica was demonstrated to have various pharmacologically active compounds in crude herbs (Li et al, 2015;Meng et al, 2017;Yang et al, 2014). Compounds such as indican, quinazolinone, indirubin (INR), tryptanthrin, glucosinolate and their derivatives extract from I. indogotica are identified to have antiviral, anti-inflammatory and anticancer effects Kaur et al, 2017;Shi et al, 2012).…”

Synthetic strategies, SAR studies, and computer modeling of indole 2 and 3-carboxamides as the strong enzyme inhibitors: a review

“…The chemistry and therapeutic study of heterocyclic compounds have been considered a powerful approach to treat a wide range of diseases [3]. In recent years, researchers have done many studies on the synthesis and biological evaluation of indole derivatives due to their biological properties and their potential to be the target [4,5].…”

Gastrodin Derivatives from Gastrodia elata

“…Undoubtedly, chemical reactions occur during decocting, and the resulting artificial products are highly suspected of playing important roles in the theory of Chinese medicine, although concrete proof is yet to be reported in many cases. Thus, we systematically studied the chemical constituents of an aqueous extract of "tian ma" to unravel the chemical and biological diversity of certain traditional Chinese medicines [26][27][28][29][30][31][32][33][34][35][36][37]. We previously reported on 51 compounds from the aqueous extract, including seven new p-hydroxybenzyl-substituted amino acids, seven new p-hydroxybenzyl-substituted glutathione derivatives, one new N,N-bis(p-hydroxybenzyl)-substituted ergothioneine, and one new bis(p-hydroxybenzyl)-substituted 9,9′-neolignan with a novel carbon skeleton [38][39][40][41].…”