Indole Aldehydes and Ketones

Mn/Al2O3 and Mn/ZrO2 as selective catalysts for the synthesis of bis(indolyl)methanes: The role of surface acidity and particle morphology

“…The reaction between indole and aldehyde most probably takes place via the formation of indolyl carbinol which further converted to an azofulvenium salt. The azofulvenium salt acts as an electrophile, which further undergo addition with another indole molecule giving corresponding bis(indolyl)methane [51] or adsorption of the molecule on surface can take place through several mechanisms. This proposed mechanism may follow Eley-Rideal model after step 1 and form azofulvenium salt, which adsorbs on the surface of the catalyst and the other indole molecule comes in contact with azofulvenium salt and forms the final product bis(indolyl)methane.…”

Functionalization of Indole and Pyrrole Cores via Michael-Type Additions

“…The pyrrole derivatives 3 and 4 display antibacterial activity [1][2][3]. Marine alkaloids (±)-B-norrhazinal (5) and (-)-rhazinilam Scheme 1 (6) possess intriguing antimitotic properties [10][11][12][13][14]. Tryptamine (7) and its derivatives are present in many naturally and synthetically derived molecules with interesting biological activities [15].…”