2023
DOI: 10.21203/rs.3.rs-2621494/v1
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Indole-3-methanol alleviates cisplatin-induced ovarian damage by inhibiting ovarian fibrosis through the TGF-β1/Smad pathway

Abstract: Background Ovarian injury is one of the side effects of chemotherapy in female patients, which seriously endangers female reproductive health. Indole-3-carbinol (I3C), a natural substance abundant in cruciferous vegetables, has been reported to attenuate tissue damage. This study aimed to investigate whether I3C could prevent from ovarian damage induced by chemotherapy. Methods A mouse model of ovarian damage was established by intraperitoneal injection of cisplatin or co-treatment with I3C. Then the ovarian i… Show more

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