2000
DOI: 10.1046/j.1365-313x.2000.00883.x
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Indole‐3‐glycerol phosphate, a branchpoint of indole‐3‐acetic acid biosynthesis from the tryptophan biosynthetic pathway in Arabidopsis thaliana

Abstract: The phytohormone indole-3-acetic acid (IAA) plays a vital role in plant growth and development as a regulator of numerous biological processes. Its biosynthetic pathways have been studied for decades. Recent genetic and in vitro labeling evidence indicates that IAA in Arabidopsis thaliana and other plants is primarily synthesized from a precursor that is an intermediate in the tryptophan (Trp) biosynthetic pathway. To determine which intermediate(s) acts as the possible branchpoint for the Trp-independent IAA … Show more

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Cited by 147 publications
(113 citation statements)
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“…Consequently, information on the biochemical processes involved in Trp-independent IAA production in plants is limited. 20,21 In plants, 4 Trp-dependent pathways have been proposed: indole-3-acetamide (IAM), indole-3-pyruvic acid (IPA), tryptamine (TRA), and indole-3-acetaldoxime pathways. 18 Although different plant species might use specific strategies or modifications to optimize synthetic pathways, plants would be expected to share evolutionarily conserved core mechanisms for IAA biosynthesis.…”
Section: Iaa Biosynthetic Pathwaysmentioning
confidence: 99%
“…Consequently, information on the biochemical processes involved in Trp-independent IAA production in plants is limited. 20,21 In plants, 4 Trp-dependent pathways have been proposed: indole-3-acetamide (IAM), indole-3-pyruvic acid (IPA), tryptamine (TRA), and indole-3-acetaldoxime pathways. 18 Although different plant species might use specific strategies or modifications to optimize synthetic pathways, plants would be expected to share evolutionarily conserved core mechanisms for IAA biosynthesis.…”
Section: Iaa Biosynthetic Pathwaysmentioning
confidence: 99%
“…The TRYPTOPHAN AMINOTRANSFERASE OF ARABIDOPSIS (TAA)/YUCCA (YUC) linear pathway has been considered as a predominant Trp-dependent auxin biosynthetic pathway (4,(6)(7)(8). However, labeling studies and analyses of Trp auxotrophic mutants have long predicted the existence of a Trp-independent IAA biosynthetic pathway (9)(10)(11)(12)(13). When the Arabidopsis and maize seedlings were fed with isotope-labeled precursor, IAA was more enriched than Trp, and the incorporation of label into IAA from Trp is low, suggesting that IAA can be produced de novo without Trp as an intermediate (11,12).…”
mentioning
confidence: 99%
“…When the Arabidopsis and maize seedlings were fed with isotope-labeled precursor, IAA was more enriched than Trp, and the incorporation of label into IAA from Trp is low, suggesting that IAA can be produced de novo without Trp as an intermediate (11,12). The Trp biosynthetic mutant trp1, defective in phosphoribosylanthranilate transferase (PAT), and indole-3-glycerol phosphate synthase (IGS) antisense plants are deficient in steps earlier than indole-3-glycerol phosphate (IGP) formation and display decreased levels of both IAA and Trp (10,14). However, the trp3 and trp2 mutants, defective in tryptophan synthase α (TSA) and tryptophan synthase β (TSB) subunits, respectively, accumulate higher levels of IAA than the wild type despite containing lower Trp levels (10,11,15,16).…”
mentioning
confidence: 99%
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