Indol-3-Carbinol – ein Glucosinolat-Derivat aus Kreuzblütler-Gemüsen zur Vorbeugung und komplementär-onkologischen Behandlung von Brustkrebs

Pfeifer, Ben; Fahrendorf, Theodor

doi:10.1055/s-0034-1395861

Cited by 4 publications

(3 citation statements)

References 72 publications

(10 reference statements)

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“…Cruciferous vegetables like cabbage, cauliflower, Brussels sprouts, and broccoli contain in the raw form indole glucosinolates (also named glucobrassicins). These molecules are converted by endogenous enzymatic digestion to several polyaromatic indolic compounds, which could be the reason for many of the physiological effects of these foods; however, among the indoles, only I3C is available at commerce as an off-white solid [ 10 – 12 ].…”

Section: Introductionmentioning

confidence: 99%

“…The synthesis of I3C occurs in sequential steps; first, an intermediate complex is developed after glycolysis from the glucosinolate structure. In the second stage, the sulfur cyanate of the intermediate is separated, and the indole ring of I3C is created [ 10 , 13 , 14 ]. The discarded cyanate makes this molecule different from the aliphatic or aromatic isothiocyanates.…”

Section: Introductionmentioning

confidence: 99%

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3,3′-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways

Reyes-Hernández,

Figueroa-González,

Quintas-Granados

et al. 2023

Cancer Cell Int

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Dietary compounds in cancer prevention have gained significant consideration as a viable method. Indole-3-carbinol (I3C) and 3,3′-diindolylmethane (DIM) are heterocyclic and bioactive chemicals found in cruciferous vegetables like broccoli, cauliflower, cabbage, and brussels sprouts. They are synthesized after glycolysis from the glucosinolate structure. Clinical and preclinical trials have evaluated the pharmacokinetic/pharmacodynamic, effectiveness, antioxidant, cancer-preventing (cervical dysplasia, prostate cancer, breast cancer), and anti-tumor activities of I3C and DIM involved with polyphenolic derivatives created in the digestion showing promising results. However, the exact mechanism by which they exert anti-cancer and apoptosis-inducing properties has yet to be entirely understood. Via this study, we update the existing knowledge of the state of anti-cancer investigation concerning I3C and DIM chemicals. We have also summarized; (i) the recent advancements in the use of I3C/DIM as therapeutic molecules since they represent potentially appealing anti-cancer agents, (ii) the available literature on the I3C and DIM characterization, and the challenges related to pharmacologic properties such as low solubility, and poor bioavailability, (iii) the synthesis and semi-synthetic derivatives, (iv) the mechanism of anti-tumor action in vitro/in vivo, (v) the action in cellular signaling pathways related to the regulation of apoptosis and anoikis as well as the cell cycle progression and cell proliferation such as peroxisome proliferator-activated receptor and PPARγ agonists; SR13668, Akt inhibitor, cyclins regulation, ER-dependent-independent pathways, and their current medical applications, to recognize research opportunities to potentially use these compounds instead chemotherapeutic synthetic drugs.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

3,3′-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways

Reyes-Hernández,

Figueroa-González,

Quintas-Granados

et al. 2023

Cancer Cell Int

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“…It appears that these large-molecule drugs can cross damaged blood-brain barriers. 11 In addition, the patient supplemented with numerous other drugs and substances that are reported in scientific publications to have antitumor properties, including artemisinin, 12,13 aspirin, 14,15 cannabidiol, 16 chloroquine, 17-19 doxycycline, 20 flaxseed oil, 21 hydroxychloroquine, 18,19 indole-3-carbinol, 22,23 melatonin, 24,25 nanocurcumin, 22,26 omega-3 fish oil, 27 pterostilbene, 28,29 quercetin, 22,30 resveratrol, 14,22 turkey tail mushroom ( Trametes [Coriolus] versicolor ), 31,32 and vitamin D 3 . 24,33,34 Since March 2013, there has been no evidence of cancer outside the patient’s central nervous system.…”

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confidence: 99%

Breast Cancer With Brain Metastases: Perspective From a Long-Term Survivor

Kofron

Chapman

2020

Integr Cancer Ther

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The purpose of this essay is to inform others that it is possible to survive breast cancer with brain metastases. The second author is the subject patient and a long-term survivor of systemic metastatic breast cancer with numerous brain metastases (corresponding to 8% survivor group). We credit her survival to a combination of (1) medicine as practiced by an excellent oncologist with whom we developed a partnership to manage the patient’s health, (2) our informed exploration of the available scientific knowledge including a review of scientific research articles that go beyond conventional care, and (3) the patient’s supplementation with numerous repurposed drugs and other substances reported to have antitumor properties. Alongside her conventional treatment (the medical standard of care), it seems likely that this supplementation has been a key factor in the patient’s long-term survival. We also point out that the lack of follow-up magnetic resonance imaging brain scans for early detection of brain metastases poses substantial risks for patients with HER2+ metastatic breast cancer in non–central nervous system locations. Thus, we suggest that research be conducted on such early detection for possible inclusion in the recommendations for the medical standard of care. Finally, medical doctors and also patients with backgrounds in biological science may wish to consider potential options and advantages of repurposed drugs and other substances reported in scientific publications when the medical standard of care has limited options for advanced cancer and other severe chronic health conditions. However, any efforts along this line by patients should be in collaboration with their medical doctors.

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Novel [(3-indolylmethylene)hydrazono]indolin-2-ones as apoptotic anti-proliferative agents: design, synthesis andin vitrobiological evaluation

Eldehna

Abo-Ashour

Ibrahim

et al. 2018

Journal of Enzyme Inhibition and Medicinal Chemistry

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On account of their significance as apoptosis inducing agents, merging indole and 3-hydrazinoindolin-2-one scaffolds is a logic tactic for designing pro-apoptotic agents. Consequently, 27 hybrids (6a–r, 9a–f and 11a–c) were synthesised and evaluated for their cytotoxicity against MCF-7, HepG-2 and HCT-116 cancer cell lines. SAR studies unravelled that N-propylindole derivatives were the most active compounds such as 6n (MCF-7; IC50=1.04 µM), which displayed a significant decrease of cell population in the G2/M phase and significant increase in the early and late apoptosis by 19-folds in Annexin-V-FTIC assay. Also, 6n increased the expression of caspase-3, caspase-9, cytochrome C and Bax and decreased the expression of Bcl-2. Moreover, compounds 6i, 6j, 6n and 6q generated ROS by significant increase in the level of SOD and depletion of the levels of CAT and GSH-Px in MCF-7.

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Indol-3-Carbinol – ein Glucosinolat-Derivat aus Kreuzblütler-Gemüsen zur Vorbeugung und komplementär-onkologischen Behandlung von Brustkrebs

Cited by 4 publications

References 72 publications

3,3′-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways

3,3′-Diindolylmethane and indole-3-carbinol: potential therapeutic molecules for cancer chemoprevention and treatment via regulating cellular signaling pathways

Breast Cancer With Brain Metastases: Perspective From a Long-Term Survivor

Novel [(3-indolylmethylene)hydrazono]indolin-2-ones as apoptotic anti-proliferative agents: design, synthesis andin vitrobiological evaluation

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