Indocyanine Green Nanoparticles for Theranostic Applications

Cai, Lintao; Sheng, Zonghai; Hu, Dehong; Xue, Miaomiao; He, Min; Gong, Peng

doi:10.5101/nml.v5i3.p145-150

Cited by 4 publications

(1 citation statement)

References 14 publications

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“…20 These strategies have proven to be effective for addressing the dye pharmacokinetics, but the photothermal degradation of ICG still remains the main challenge that has hampered its widespread use in clinical applications. 21,22 In 1936, E. Jelley discovered the molecular aggregation phenomenon of pseudo-isocyanine chloride (PIC), 23 introducing the concept of J-aggregates which have a bathochromic shift as a hallmark. Since then, plenty of work has been done concerning the light absorption properties of cyanine dyes.…”

Section: Introductionmentioning

confidence: 99%

Exploiting cyanine dye J-aggregates/monomer equilibrium in hydrophobic protein pockets for efficient multi-step phototherapy: an innovative concept for smart nanotheranostics

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Exploiting cyanine dye J-aggregates/monomer equilibrium in hydrophobic protein pockets for efficient multi-step phototherapy: an innovative concept for smart nanotheranostics

et al. 2021

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Optical Characteristics of Indocyanine Green J-Aggregates Induced by Cisplatin for Phototheranostic Applications

Vincy

Bhatia

Vankayala

2022

ACS Biomater. Sci. Eng.

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The development of an optical system for combinatorial theranostics is of significant interest. Clinical translation of such theranostic agents need to cross several barriers. Herein, we have developed a facile method for the preparation of J-aggregates using FDA approved agents, namely, NIR fluorophore indocyanine green (ICG) and a chemotherapeutic drug, cisplatin (CDDP), which induces ICG to form indocyanine green J-aggregates (IJAs). The formation of IJAs has been characterized by the formation of a new absorption peak centered at ∼896 nm. The existing methods to synthesize IJAs have used several harsh reaction conditions, such as elevated temperatures, for a prolonged time duration (∼60 days). To the best of our knowledge, for the first time, we have reported the formation of IJAs assisted by CDDP at 37 °C temperature within 12 h. The presence of CDDP in ICG favors IJA formation and thereby reduces the harshness of the reaction conditions in the conventionally followed protocols. Moreover, the presence of CDDP can facilitate photoactivated combinatorial therapy. The as synthesized IJA optical system has superior properties to those of free ICG, in terms of diagnostic and therapeutic capabilities (being activatable at ∼896 nm wavelength, which can achieve deeper tissue penetration) and excellent optical and storage stability. The facile synthesis proposed along with CDDP incorporation makes the optical system a clinically relevant one-component theranostic agent.

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Cyanine-Curcumin Assembling Nanoparticles for Near-Infrared Imaging and Photothermal Therapy

Zhang

Liu

et al. 2016

ACS Biomater. Sci. Eng.

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Near-infrared (NIR) imaging and photothermal therapy (PTT) based on the multifunctional cyanine dyes has shown great promise for cancer therapy. However, most of the PTT agents are often limited by low drug loading, short circulation time, and low biocompatibility. Herein, we developed cyanine-curcumin assembling nanoparticles (CCNPs) via a single-step reprecipitation method. IR-780-C4 (Cyc4) was employed as a photothermal and NIR imaging agent. Self-assembly of Cyc4 and curcumin in aqueous solution could be performed in the absence of surfactants or adjuvants, which is a simple and efficient way to fabricate nanomedicine with high drug loading. Formed CCNPs showed monodispersity, good stability in physiological conditions, and lower cytotoxicity. Moreover, CCNPs possess the high loading (70%) of cyanine dyes and a higher photothermal conversion efficacy than free Cyc4, which contribute to a decrease in the application dosage of cyanine dyes in cancer therapy. Importantly, CCNPs exhibited excellent NIR imaging capacity and photothermal tumor ablation under laser irradiation in vitro and in vivo. This work highlights the potential of using self-assembling of drug molecules to develop functional nanoparticles for drug delivery and cancer therapy.

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Indocyanine Green Nanoparticles for Theranostic Applications

Cited by 4 publications

References 14 publications

Exploiting cyanine dye J-aggregates/monomer equilibrium in hydrophobic protein pockets for efficient multi-step phototherapy: an innovative concept for smart nanotheranostics

Exploiting cyanine dye J-aggregates/monomer equilibrium in hydrophobic protein pockets for efficient multi-step phototherapy: an innovative concept for smart nanotheranostics

Optical Characteristics of Indocyanine Green J-Aggregates Induced by Cisplatin for Phototheranostic Applications

Cyanine-Curcumin Assembling Nanoparticles for Near-Infrared Imaging and Photothermal Therapy

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