Indocyanine green fluorescent imaging for detecting extrahepatic metastasis of hepatocellular carcinoma

Abstract

Extrahepatic metastases from HCC exhibited ICG fluorescence when illuminated by near-infrared light, indicating their capability to transport ICG. This imaging can be a useful tool for intraoperative detection of metastasis in HCC patients.

Indocyanine Green Fluorescence Navigation Thoracoscopic Metastasectomy for Pulmonary Metastasis of Hepatocellular Carcinoma

“…2) Satou et al reported that ICG fluorescence could also be observed at extrahepatic metastases. 3) They reported that they had succeeded in identifying one pulmonary metastases out of two lesions that were explored using an ICG-NIF system; however, they reported that the excitation light was unable to reach another three lesions through a thoracotomy because their system was not an endoscopic device. In the present study, we used an endoscopic ICG-NIF system, which is able to access the entire thoracic cavity, and clear blue fluorescence was observed at the metastatic site.…”

“…ICG fluorescence is detectable when a target lesion exists within 1 cm from the organ surface, 10,11) and small metastatic lesions of HCC with a diameter of 3 mm were reported detectable by an ICG-NIF system when the lesions were close to the pleural surface. 1,3) Therefore, the ICG-NIF system may be useful in identifying small metastatic lesions without the need of preoperative marking and exploration of small lesions unidentified by preoperative imaging.…”

“…[1][2][3] Recent reports demonstrated that ICG fluorescence imaging for HCC patients presents clear boundaries between tumors and normal tissue. This is the first report of thoracoscopic metastasectomy using ICG fluorescence for a patient with pulmonary metastasis of HCC.…”

Management of abdominal malignancies: updates from the International Association of Surgeons, Gastroenterologists and Oncologists

“…Norihiro Kokudo (Department of Surgery, University of Tokyo, Japan) spoke about advanced liver resection using indocyanine green (ICG) fluorescence [10].…”

Intraoperative Photodynamic Surgery (iPDS) with Acridine Orange for Musculoskeletal Sarcomas

“…It would result in good functioning of organs or tissues. However, no such ideal method has been devised yet, although there are scattered reports of the use of various kinds of fluorescence dyes towards achieving this purpose [1][2][3][4][5]. The present review paper introduces one such ideal agent that could aid surgeons in realizing their dream: acridine orange (AO).…”