Indocyanine green fluorescence mapping for sentinel lymph node biopsy in early breast cancer

Pitsinis, Vassilis; Provenzano, Elena; Kaklamanis, Loukas; Wishart, Gordon; Benson, John R.

doi:10.1016/j.suronc.2015.10.002

Cited by 56 publications

(43 citation statements)

References 19 publications

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“…Of 567 studies identified from the initial search, 35 cohort studies (4244 subjects) satisfied the inclusion and exclusion criteria, and were included in this meta‐analysis (Fig . , Table ).…”

Section: Resultsmentioning

confidence: 99%

Network meta‐analysis of novel and conventional sentinel lymph node biopsy techniques in breast cancer

et al. 2019

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Background The aim of this network meta‐analysis was to compare the performance of blue dye alone or in combination with radioisotope (technetium‐99m, Tc) with three novel techniques for sentinel lymph node detection in breast cancer: indocyanine green fluorescence (ICG), superparamagnetic iron oxide (SPIO) nanoparticles and contrast‐enhanced ultrasound imaging (CEUS). Methods PubMed, Embase, the Cochrane Library, China Knowledge Research Integrated Database, http://clinicaltrials.gov and OpenGrey databases were searched up to 31 November 2017, without language restriction. Studies that compared the detection performance of at least one of the novel methods (ICG, SPIO and CEUS) with that of traditional methods (blue dye and/or radioisotope) were included in network meta‐analysis. Results Thirty‐five studies were included. Pooled risk ratios (RRs) for Tc (1·09, 95 per cent c.i. 1·04 to 1·15), ICG (1·12, 1·07 to 1·16) and SPIO (1·09, 1·01 to 1·18) showed statistically better performance in detecting sentinel lymph nodes than blue dye alone. ICG had the lowest false‐negative rate, with a RR of 0·29 (0·16 to 0·54), followed by Tc (RR 0·44, 0·20 to 0·96) and SPIO (RR 0·45, 0·14 to 1·45), with blue dye alone as the reference group. Conclusion SPIO or ICG alone are superior to blue dye alone and comparable to the standard dual‐modality technique of blue dye with Tc.

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Section: Resultsmentioning

confidence: 99%

Network meta‐analysis of novel and conventional sentinel lymph node biopsy techniques in breast cancer

et al. 2019

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“…The greatest advantage of the ICG fluorescence imaging system is that it allows visualization of SN and afferent lymphatic vessels from primary tumor sites more clearly than a conventional dye approach based on visual recognition without special tools. To date, several investigators have demonstrated the clinical benefit of the ICG fluorescence imaging approach for SN detection in patients with several malignancies, including gastric cancer 16, 17, 18, 19…”

Section: A Novel Imaging System Developed For Sn Detectionmentioning

confidence: 99%

Novel surgical approach based on the sentinel node concept in patients with early gastric cancer

Natsugoe

Arigami

Uenosono

et al. 2017

Annals of Gastroent Surgery

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Recent prospective multicenter trials have demonstrated the clinical safety and efficacy of sentinel node navigation surgery (SNNS) in patients with early gastric cancer. Further, development of an intraoperative imaging system and an indocyanine green fluorescence imaging approach has been attracting attention as a novel tool for detection of the sentinel node (SN). The greatest advantage of an in vivo imaging system is that it visualizes SN and afferent lymphatic vessels from the primary tumor site more clearly than the conventional dye approach. Besides visualization of the SN, it is also essential to accurately assess the presence or absence of lymph node metastasis in the intraoperative management of SNNS. However, the clinical significance of lymph node micrometastasis (LNM) in patients with gastric cancer remains controversial. Reverse transcription‐polymerase chain reaction (RT‐PCR) is one of the representative assays used to identify LNM. A rapid RT‐PCR assay that completes the detection of LNM within approximately 40 minutes has recently been produced and applied in the clinical management of SNNS. From the viewpoint of surgical methods, modified laparoscopic and endoscopic cooperative surgery with non‐exposed approaches has recently been highlighted as a promising technique to prevent tumor dissemination caused by surgical procedures, and is likely to be clinically applied to SNNS in the future. When carrying out SNNS as a minimally invasive surgery, it is important to consider the balance between post‐surgical quality of life and curability. Future prospective studies on SNNS will greatly contribute to furthering its establishment as a beneficial procedure for patients with early gastric cancer.

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“…Some investigators analyzed the false-negative rate of ICG in SLNB and found it to be lower than 10 % [22,24,[26][27][28][30][31][32][33]. A meta-analysis of six studies, which used ICG as a tracer in SLNB of breast cancer patients, reported the sensitivity of about 92 % (85 %-96 %) and the specificity of about 100 % (97 %-100 %) [34].…”

Section: The Developing Stagementioning

confidence: 99%

Detection of Sentinel Lymph Nodes with Near-Infrared Imaging in Malignancies

Zeng

Bai

et al. 2018

Mol Imaging Biol

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Optical molecular imaging, a highly sensitive and noninvasive technique which is simple to operate, inexpensive, and has the real-time capability, is increasingly being used in the diagnosis and treatment of carcinomas. The near-infrared fluorescence dye indocyanine green (ICG) is widely used in optical imaging for the dynamic detection of sentinel lymph nodes (SLNs) in real time improving the detection rate and accuracy. ICG has the advantages of low scattering in tissue absorbance, low auto-fluorescence, and high signal-to-background ratio. The detection rate of axillary sentinel lymph nodes biopsy (SLNB) in breast cancers with ICG was more than 95 %, the false-negative rate was lower than 10 %, and the average detected number ranged from 1.75 to 3.8. The combined use of ICG with nuclein or blue dye resulted in a lower falsenegative rate. ICG is also being used for the sentinel node detection in other malignant cancers such as head and neck, gastrointestinal, and gynecological carcinomas. In this article, we provide an overview of numerous studies that used the near-infrared fluorescence imaging to detect the sentinel lymph nodes in breast carcinoma and other malignant cancers. It is expected that with improvements in the optical imaging systems together with the use of a combination of multiple dyes and verification in large clinical trials, optical molecular imaging will become an essential tool for SLN detection and image-guided precise resection.

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Indocyanine green fluorescence mapping for sentinel lymph node biopsy in early breast cancer

Cited by 56 publications

References 19 publications

Network meta‐analysis of novel and conventional sentinel lymph node biopsy techniques in breast cancer

Network meta‐analysis of novel and conventional sentinel lymph node biopsy techniques in breast cancer

Novel surgical approach based on the sentinel node concept in patients with early gastric cancer

Detection of Sentinel Lymph Nodes with Near-Infrared Imaging in Malignancies

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