Indocyanine green-augmented diode laser therapy vs. long-pulsed Nd:YAG (1064 nm) laser treatment of telangiectatic leg veins: a randomized controlled trial

Klein, Annette; Buschmann, M.; Babilas, Philipp; Landthaler, Míchael; Bäumler, Wolfgang

doi:10.1111/bjd.12415

Cited by 21 publications

(8 citation statements)

References 32 publications

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“…232 The superiority of indocyanine green was reported also versus Nd:YAG, even if associated with higher pain scores. 233 Empirically, radiofrequency diathermy is sometimes used to treat telangiectasia and residual veins. The panel was not able to find guidelines and document providing evidence-based recommendations on its use.…”

Section: Discussionmentioning

confidence: 99%

Global guidelines trends and controversies in lower limb venous and lymphatic disease

et al. 2019

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Guidelines are fundamental in addressing everyday clinical indications and in reporting the current evidence-based data of related scientific investigations. At the same time, a spatial and temporal issue can limit their value. Indeed, variability in the recommendations can be found both among the same nation different scientific societies and among different nations/continents. On the other side, Garcia already published in 2014 data showing how, after three years in average, one out of five recommendations gets outdated (Martinez Garcia LM, Sanabria AJ, Garcia Alvarez E, et al. The validity of recommendations from clinical guidelines: a survival analysis. CMAJ 2014;186(16):1211–1219). The present document reports a narrative literature revision on the major international recommendations in lower limb venous and lymphatic disease management, focusing on the different countries’ guidelines, trends and controversies from all the continents, while identifying new evidence-based data potentially influencing future guidelines. World renowned experts’ opinions are also provided. The document has been written following the recorded round tables scientific discussions held at the vWINter international meeting (22–26 January 2019; Cortina d’Ampezzo, Italy) and the pre- and post-meeting literature search performed by the leading experts.

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Section: Discussionmentioning

confidence: 99%

Global guidelines trends and controversies in lower limb venous and lymphatic disease

et al. 2019

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“…IPLS are not regarded as first‐line treatment as there is a lack of controlled clinical studies and a relatively high risk of damaging non‐vascular structures. Indocyanine green injected shortly before laser radiation augments absorption of wavelengths between 700 and 801 nm . Results are promising, but clinical evidence is still too weak to justify this technique as standard therapy.…”

Section: Treatment Of Different Vascular Lesionsmentioning

confidence: 99%

“…Indocyanine green injected shortly before laser radiation augments absorption of wavelengths between 700 and 801 nm. 168 Results are promising, but clinical evidence is still too weak to justify this technique as standard therapy.…”

Section: Leg Veins and Telangiectasiasmentioning

confidence: 99%

Guidelines of care for vascular lasers and intense pulse light sources from the European Society for Laser Dermatology

Adamič¹,

Pavlović

Rubin

et al. 2015

Acad Dermatol Venereol

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Aim Lasers and non-coherent intense pulse light sources (IPLS) are based on the principle of selective photothermolysis and can be used for the treatment of many vascular skin lesions. A variety of lasers has been developed for the treatment of congenital and acquired vascular lesions which incorporate these concepts into their design. Although laser and light sources are very popular due to their non-invasive nature, caution should be considered by practitioners and patients to avoid permanent side-effects. The aim of these guidelines is to give evidence-based recommendations for the use of lasers and IPLS in the treatment of vascular lesions. Results Lasers and IPLS are very useful and sometimes the only available method to treat various vascular lesions. It is of a paramount importance that the type of laser or IPLS and their specific parameters are adapted to the indication but also that the treating physician is familiar with the device to be used. The crucial issue in treating vascular lesions is to recognize the immediate end-point after laser treatment. This is the single most important factor to ensure both the efficacy of the treatment and avoidance of serious side-effects. Methods Conflicts of interestNone declared. Funding sourceNone.Since the publication of previous European Society of Laser Dermatology (ESLD) guidelines in 2007, there have been significant advances in the field of laser treatment of common vascular lesions.1 These guidelines have been updated by the Consensus Panel under the auspices of the ESLD. Methodology, search strategy and recommendation formulation are described in Appendix II. A brief overview of vascular lasersStandard vascular lasers include pulsed dye lasers (585 and 595 nm), and KTP-lasers (532 nm), followed by longer wavelength lasers such as alexandrite lasers (755 nm), diode lasers (800-900 nm) and millisecond Nd:YAG lasers (1064 nm). New developments include a non-uniform pulse sequence or a dual-wavelength modality (combined dual wavelength 595 and 1064 nm-pulsed dye and Nd:YAG laser) and microsecond Nd: YAG lasers. [2][3][4][5][6] Even fractional photothermolysis has begun to be used for selected vascular lesions. Lasers' and intense pulse light sources (IPLS) effects are based on the principle of selective photothermolysis. In general, they deliver a precisely graded aliquot of energy to a defined area of the skin in a reproducible, standardized manner that almost always involves addition or evacuation of heat. The greatestThe first two authors have contributed equally to the manuscript.

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“…After manuscript review, two were excluded for being duplicates and 27 were excluded for not being RCTs. This left 181 articles in 27 journals to be included in the review . Of these, 137 studies had parallel‐armed control groups, 42 had placebo control groups, one was a cross‐over design and one used no treatment as the control group.…”

Section: Resultsmentioning

confidence: 99%

Statistical reporting in randomized controlled trials from the dermatology literature: a review of 44 dermatology journals

McClean

Silverberg

2015

Br J Dermatol

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Indocyanine green-augmented diode laser therapy vs. long-pulsed Nd:YAG (1064 nm) laser treatment of telangiectatic leg veins: a randomized controlled trial

Abstract: ICG+DL therapy represents a new and promising treatment modality for TLV, with high clearance rates and a very good cosmetic outcome after one single treatment session.

Cited by 21 publications

References 32 publications

Global guidelines trends and controversies in lower limb venous and lymphatic disease

Global guidelines trends and controversies in lower limb venous and lymphatic disease

Guidelines of care for vascular lasers and intense pulse light sources from the European Society for Laser Dermatology

Statistical reporting in randomized controlled trials from the dermatology literature: a review of 44 dermatology journals

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