Indocyanine Green–Assisted Internal Limiting Membrane Peeling for Macular Holes To Stain or Not To Stain?

Mata, Andrea P Da; Riemann, Christopher D.; Nehemy, Márcio Bittar; Foster, Robert E.; Petersen, Michael R.; Burk, Scott

doi:10.1097/00006982-200506000-00002

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Cited by 24 publications

(12 citation statements)

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“…In fact, Wollensak et al 20 demonstrated increased biomechanical stiffness of porcine ILM after ICG and light exposure. 17 In summary, eccentric macular holes occurring after otherwise successful epimacular proliferation peeling are uncommon. To our knowledge, no case series such as this one has been described in the literature.…”

Section: Discussionmentioning

confidence: 99%

Eccentric Macular Holes After Vitrectomy With Peeling of Epimacular Proliferation

Mason

Feist

Albert

2007

Retina

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Section: Discussionmentioning

confidence: 99%

Eccentric Macular Holes After Vitrectomy With Peeling of Epimacular Proliferation

Mason

Feist

Albert

2007

Retina

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“…Only a prospective, randomized, double-masked clinical trial will determine whether the current "off-label" use of ICG in this new surgical approach is worthy, although such a study is unlikely to be performed in the near future. 100 Such a randomized, controlled trial should also assess whether there is truly a need for ILM peeling at all. Currently, there are several possible scenarios regarding the use of ICG in chromovitrectomy.…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of Intravitreal Toxicity of Indocyanine Green Dye

Rodrigues¹,

Meyer²,

Mennel³

et al. 2007

Retina

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Much evidence supports that ICG dye has a dose-dependent toxic effect on the retina. Therefore, the following recommendations to minimize toxic effects on the retina are proposed: dye injection in concentrations as low as possible; avoidance of repeated ICG injections onto bare retina; dye injection far from the macular hole to prevent direct dye contact with the RPE; short incubation time of ICG in the vitreous cavity to diminish the concentration in contact with the retinal tissue; and the light pipe kept far from the retina throughout the whole surgical procedure.

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“…15 These and other evidence to defend the safety of ICG have been recently reviewed. 44 Nevertheless, the conflicting opinions and results have caused many to advocate caution, further study, or restraint regarding the use of ICG. 45,46 Sodium hyaluronate use has been suggested to block ingress of the ICG through the macular hole to the subretinal space.…”

Section: Discussionmentioning

confidence: 99%