Indocyanine Green Angiography in Classic Choroidal Neovascularization

Gelişken, Faik; Inhoffen, Werner; Schneider, Ulrike; Stroman, Gesa A.; Kreissig, Ingrid

doi:10.1016/s0021-5155(98)00010-0

Cited by 12 publications

(4 citation statements)

References 12 publications

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“…2 Features of Type 2 NV have been widely analyzed with FA, ICGA, and SD-OCT descriptions. [7][8][9][10] In the present series, Type 2 NV could be visualized in all cases by OCT-A, with 1 of 2 very typical patterns. Neovascular membranes appeared either as a glomerulus-shaped lesion or a medusashaped complex in the outer retina and corresponded topographically to a well-demarcated hyperfluorescent lacy area in the early frames of FA.…”

Section: Discussionsupporting

confidence: 64%

“…[7][8][9][10] Optical coherence tomography angiography (OCT-A) is a novel and noninvasive imaging tool that allows the visualization of retinal microvasculature by detecting the intravascular blood flow, based on splitspectrum amplitude-decorrelation angiography and/or an "en face" OCT-derived technique, 11 without any dye injection. It allows imaging of the dynamic motion of erythrocytes using sequential OCT cross-sectional scans, which are repeated at the same location on the retina.…”

mentioning

confidence: 99%

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Type 2 Neovascularization Secondary to Age-Related Macular Degeneration Imaged by Optical Coherence Tomography Angiography

Ameen

Cohen

Semoun

et al. 2015

Retina

123

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Section: Discussionsupporting

confidence: 64%

mentioning

confidence: 99%

Type 2 Neovascularization Secondary to Age-Related Macular Degeneration Imaged by Optical Coherence Tomography Angiography

Ameen

Cohen

Semoun

et al. 2015

Retina

123

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“…Type 2 CNV have been described by Gass as a well defined hyperfluorescent lacy pattern on FA with early staining and progressive leakage [2]. They appear on SD-OCT as a hyperreflective subretinal lesion, situated above the retinal pigment epithelium (RPE) [6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography angiography features of choroidal neovascularization secondary to angioid streaks

Chapron

Mimoun

Mière

et al. 2018

Eye

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Purpose To characterize the features of choroidal neovascularization (CNV) secondary to angioid streaks (AS) with optical coherence tomography angiography (OCT-A) and to assess its sensitivity in CNV detection in this particular context. Methods Consecutive patients, both with treatment-naïve and recurrent CNV associated with angioid streaks were prospectively analyzed. All patients underwent macular imaging by fluorescein angiography (FA), indocyanine green angiography (ICGA), spectral-domain (SD)-OCT, and OCT-A (AngioVue, Optovue, Optovue Inc., Freemont, CA, USA). OCT-A detection rate of CNV associated to AS was evaluated by two independent observers. We studied the association between OCT-A feature and either exudative or active status using Fisher exact test. Results A total of 32 eyes of 18 consecutive patients were included in the analysis. OCT-A was able to detect CNV associated with angioid streaks in 87.5 % (28/32) eyes. OCT-A phenotypes of CNV were classified into interlacing pattern in 9 eyes, pruned vascular tree pattern in 7 eyes, and combined pattern in 12 eyes (Interuser agreement: 0.871 ± 0.071). CNV were not detectable in 4/32 eyes. There was a statistically significant association between the presence in OCT-A of densely ramified networks with both previous treatment status in the last 6 months (p < 0.001) and with exudative signs on SD-OCT (p = 0.014). Conclusion OCT-A appears as a sensitive tool for detection of CNV secondary to AS. The interlacing pattern was significantly associated with active and exudative features.

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“…1, 2 In ophthalmology, ICG has been used to evaluate the choroidal circulation 3 and has played a significant role in the diagnosis of chorioretinal disorders . 4-7 Because systemic adverse effects are rare, 8 ICG is thought to be safe when injected intravenously. ICG is also useful in staining the internal limiting membrane (ILM) of the retina for visualization during vitrectomy 9 and ICG is now routinely used in retinal surgeries for repair of macular holes 9, 10 and in epiretinal membrane surgeries 11.…”

mentioning

confidence: 99%

Involvement of Illumination in Indocyanine Green Toxicity After Its Washout in the Ex Vivo Rat Retina

Tokuda

Zorumski

Izumi

2009

Retina

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Purpose To elucidate the involvement of illumination in indocyanine green (ICG) retinal toxicity. Methods We incubated isolated rat retinas with or without illumination after exposure to 0.5 % ICG. We also examined whether a time lag following ICG exposure prior to illumination altered the damage. Toxicity was evaluated by histological and biochemical assays, including measurement of lactate dehydrogenase (LDH) release. Results Retinas fixed immediately after ICG exposure showed minimal morphological changes. However, illumination for 3 h at 34 °C starting after washout of ICG selectively damaged the outer nuclear layer. Retinas incubated for 3 h under the same condition in the dark showed preserved morphology but were damaged by subsequent illumination. When retinas were illuminated after washout of ICG at a lower temperature (30 °C), the damage was attenuated. Results obtained using LDH release were consistent with these morphological changes. Conclusions Incubating retinas in the dark and cooling after ICG exposure significantly inhibited retinal damage, suggesting that ICG interacts with illumination to induce retinal damage. Summary Statement Illumination after indocyanine green (ICG) exposure damaged the outer nuclear layer in isolated rat retinas. Incubating retinas in the dark or cooling after its exposure attenuated the damage, indicating phototoxic properties of ICG. Phototoxic damage developing after ICG exposure suggests the importance of protecting the retina from light during and after vitrectomy.

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Indocyanine Green Angiography in Classic Choroidal Neovascularization

Cited by 12 publications

References 12 publications

Type 2 Neovascularization Secondary to Age-Related Macular Degeneration Imaged by Optical Coherence Tomography Angiography

Type 2 Neovascularization Secondary to Age-Related Macular Degeneration Imaged by Optical Coherence Tomography Angiography

Optical coherence tomography angiography features of choroidal neovascularization secondary to angioid streaks

Involvement of Illumination in Indocyanine Green Toxicity After Its Washout in the Ex Vivo Rat Retina

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