Indobufen

Abstract

Indobufen is as effective as warfarin in the prophylaxis of thromboembolic events in at risk patients with nonrheumatic atrial fibrillation, as aspirin plus dipyridamole in the prevention of CABG occlusion and may be more effective than aspirin or pentoxifylline in improving walking capacity in patients with intermittent claudication. The improved tolerability profile of indobufen (favourable gastric tolerance and reduced haemorrhagic complications) compared with aspirin 300 to 325 mg 3 times daily or warfarin, in addition to a similar antiplatelet effect, suggests indobufen can be considered a drug with a definite role in the management of atherothrombotic events. In particular, indobufen may be an effective alternative for at risk patients with nonrheumatic atrial fibrillation in whom anticoagulant therapy is contraindicated or who are at higher risk of bleeding.

Quality of domestic cat semen collected by urethral catheterization after the use of different alpha 2-adrenergic agonists

“…Semen collection has been performed using urethral catheterization after the administration of an α 2adrenergic agonist in cats, but medetomidine drugs are emphasized in several studies; their effectiveness for this procedure is referenced in both domestic and wild cats. [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] MED is a selective α 2 -adrenergic agonist composed of the enantiomers DEX and levomedetomidine. 24 DEX is the newest and most selective α 2 -adrenergic agonist used with effects such as sedation, analgesia and anxiolysis.…”

“…24 DEX is the newest and most selective α 2 -adrenergic agonist used with effects such as sedation, analgesia and anxiolysis. 17 Its efficiency as an ejaculation inductor has also been demonstrated in domestic cats. 9 Considering that studies performed on domestic cats contribute to the application of the sperm collection by urethral catheterization technique in wild species, 11 these results regarding the effectiveness of the two drugs generate valuable knowledge, especially in countries that lack the license to commercialize MED.…”

“…7,8,13,15 DEX is the newest and most selective α 2 -adrenergic agonist with effects such as sedation, analgesia and anxiolysis. 16,17 Its efficiency as an inductor of ejaculation in domestic cats has also been demonstrated. 9 This technique offers semen with motility parameters that can reach 90% 9 and progressive motility of 70%, 18 and becomes important when using the domestic cat as a model for assisted reproduction processes in wild cats.…”

Electroselective C(sp3)–H deuteration of isoindolinones

“…3 Indobufen is an antiplatelet aggregation drug. 4 Ubisindine is an antiarrhythmic agent. 5 Isoindolinones bear a common benzylic methylene, which is susceptible to P450 oxidative metabolism in vivo (Fig.…”

Resolution of indobufen enantiomers by capillary zone electrophoresis Pharmacokinetic studies of human serum

“…1) and exists in two enantiomeric forms as (−)-R and (+)-S. Its structure is similar to that of derivatives of 2-arylpropionic acid but profens ␣-methyl group is replaced by an ␣-ethyl group. Up to now, INDB has been used in the medical treatment as a racemate, though its anti-platelet and anti-inflammatory activity resides mainly in (+)-S-enantiomer (eutomer) [1][2][3][4]. After administration of rac-INDB to healthy volunteers [5,6] or patients with obliterative atherosclerosis [7], serum levels of the (+)-S enantiomer were significantly lower than those of the (−)-R antipode.…”