Individuals with migraine have a different dry eye symptom profile than individuals without migraine

Farhangi, Monika; Diel, R.; Buse, Dawn C.; Huang, Amy; Levitt, Roy C.; Sarantopoulos, Constantine; Felix, Elizabeth R.; Galor, Anat

doi:10.1136/bjophthalmol-2018-313471

Cited by 25 publications

(10 citation statements)

References 34 publications

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“…Individuals with migraine had higher neuropathic eye pain scores on the NPSI-E compared with individuals without migraine (39.9±23.3 vs. 21.9±20.2, P =0.0001), despite having similar ocular surface parameters. 51 These findings suggest a relationship between ocular and systemic pain and may be applicable to individuals with SS.…”

Section: What Can Eye Findings Tell Us About Systemic Nerve Status In...mentioning

confidence: 83%

Rethinking Sjögren Beyond Inflammation: Considering the Role of Nerves in Driving Disease Manifestations

Sanchez,

Dobzinski,

Fox

et al. 2024

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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Sjögren syndrome (SS) is a chronic inflammatory autoimmune disease characterized by destruction of mucosal glands resulting in dry eye and dry mouth. Ocular presentations can be heterogenous in SS with corneal nerves abnormalities that are structural, functional, or both. Some individuals present with corneal hyposensitivity, with a phenotype of decreased tear production and epithelial disruption. Others present with corneal hypersensitivity, with a phenotype of neuropathic pain including light sensitivity and pain out of proportion to signs of tear dysfunction. A similar correlate can be found outside the eye, with dry mouth predominating in some individuals while pain conditions predominate in others. Understanding how nerve status affects SS phenotype is an important first step to improving disease management by targeting nerve abnormalities, as well as inflammation.

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Section: What Can Eye Findings Tell Us About Systemic Nerve Status In...mentioning

confidence: 83%

Rethinking Sjögren Beyond Inflammation: Considering the Role of Nerves in Driving Disease Manifestations

Sanchez,

Dobzinski,

Fox

et al. 2024

Eye &Amp; Contact Lens: Science &Amp; Clinical Practice

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“…20,57 Specifically, some studies, like ours, did not find differences in inflammatory markers in MF/CFS versus control patients. In one study, cytokine expression levels by peripheral blood mononuclear cells (TNFα: 89 vs. 45 [32][33][34][35][36][37][38][39][40][41][42][43][44][45]) (all units in mean intensity of fluorescence with [median interquartile range], all p-values >0.05). 58 On the other hand, other studies have noted differences in serum inflammatory markers in ME/CFS compared to controls, with differences in the specific markers noted across studies.…”

Section: Discussionmentioning

confidence: 99%

“…Beyond ME/CFS, a discordance between ocular symptoms and signs has been observed across various chronic pain conditions, 43,44 and is thought to reflect generalised hypersensitivity due to neuropathic mechanisms 45 . One example is fibromyalgia, a neurological disorder with significant symptom overlap with ME/CFS 7 .…”

Section: Discussionmentioning

confidence: 99%

Dry eye symptoms and signs in United States Gulf War era veterans with myalgic encephalomyelitis/chronic fatigue syndrome

Sanchez,

Kim,

Locatelli

et al. 2023

Clinical Exper Ophthalmology

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BackgroundTo examine ocular symptoms and signs of veterans with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) diagnosis, ME/CFS symptoms, and controls.MethodsThis was a prospective, cross‐sectional study of 124 South Florida veterans in active duty during the Gulf War era. Participants were recruited at an ophthalmology clinic at the Miami Veterans Affairs Hospital and evaluated for a diagnosis of ME/CFS, or symptoms of ME/CFS (intermediate fatigue, IF) using the Canadian Consensus criteria. Ocular symptoms were assessed via standardised questionnaires and signs via comprehensive slit lamp examination. Inflammatory blood markers were analysed and compared across groups.ResultsMean age was 55.1 ± 4.7 years, 88.7% identified as male, 58.1% as White, and 39.5% as Hispanic. Ocular symptoms were more severe in the ME/CFS (n = 32) and IF (n = 48) groups compared to controls (n = 44) across dry eye (DE; Ocular Surface Disease Index [OSDI]: 48.9 ± 22.3 vs. 38.8 ± 23.3 vs. 19.1 ± 17.8, p < 0.001; 5 item Dry Eye Questionnaire [DEQ‐5]: 10.8 ± 3.9 vs. 10.0 ± 4.6 vs. 6.6 ± 4.2, p < 0.001) and pain‐specific questionnaires (Numerical Rating Scale 1‐10 [NRS] right now: 2.4 ± 2.8 vs. 2.4 ± 2.9 vs 0.9 ± 1.5; p = 0.007; Neuropathic Pain Symptom Inventory modified for the Eye [NPSI‐E]: 23.0 ± 18.6 vs. 19.8 ± 19.1 vs. 6.5 ± 9.0, p < 0.001). Ocular surface parameters and blood markers of inflammation were generally similar across groups.ConclusionIndividuals with ME/CFS report increased ocular pain but similar DE signs, suggesting that mechanisms beyond the ocular surface contribute to symptoms.

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“…Patients with migraines had varying degrees of eye dryness and corneal pain, [56] often had DED, [57] and had poor visual ability [58] . They have been shown to have enhanced corneal discomfort, especially on the affected side [59] .…”

Section: Corneal Pain and Trigeminal Nerve Sensitizationmentioning

confidence: 99%

Calcitonin gene‐related peptide and persistent corneal pain: A trigeminal nerve sensitization perspective

Hong,

Ding,

Xiong

et al. 2023

Brain-X

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Persistent corneal pain (PCP) has excellent research prospects, especially the central sensitization mechanism of the trigeminal nerve, which is involved in migraine, corneal pain, and trigeminal neuralgia. The cornea has dense sensory innervation, and repeated corneal neuropathic pain has been associated with trigeminal nerve central sensitization, which is induced in PCP. The calcitonin gene‐related peptide (CGRP) is involved in corneal pain conduction, injury protection, and immune homeostasis. A high CGRP level maintains corneal pain perception and protects corneal epithelial cells. However, a persistently high CGRP level causes hypersensitivity of the corneal and trigeminal nerves, resulting in PCP. CGRP‐related drugs can effectively improve trigeminal nerve sensitization and relieve central sensitization‐related pain (PCP, migraine, and trigeminal neuralgia). Exploring the role of CGRP in PCP's pain sensitization mechanism is vital in the pain perception field, with the potential to improve the quality of life of patients with PCP and strengthen the understanding of CGRP's dual role in corneal pain.

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Individuals with migraine have a different dry eye symptom profile than individuals without migraine

Cited by 25 publications

References 34 publications

Rethinking Sjögren Beyond Inflammation: Considering the Role of Nerves in Driving Disease Manifestations

Rethinking Sjögren Beyond Inflammation: Considering the Role of Nerves in Driving Disease Manifestations

Dry eye symptoms and signs in United States Gulf War era veterans with myalgic encephalomyelitis/chronic fatigue syndrome

Calcitonin gene‐related peptide and persistent corneal pain: A trigeminal nerve sensitization perspective

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