Individuals at increased coronary heart disease risk are characterized by an impaired microvascular function in skin

IJzerman, Richard G.; Jongh, Renate T. de; Beijk, Marcel A.M.; Weissenbruch, Mirjam M. van; Waal, Henriëtte A. Delemarre-van de; Serné, Erik H.; Stehouwer, Coen D.A.

doi:10.1046/j.1365-2362.2003.01179.x

Cited by 235 publications

(183 citation statements)

References 46 publications

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“…Recent studies have indicated that changes in the cutaneous microvasculature often mirror changes in vessels of different size (Debbabi et al, 2010) and in other vascular beds, such as the coronary microcirculation (Khan et al, 2008). In fact, increasing evidence indicates that the cutaneous microcirculation can serve as a representative model to examine mechanisms of vascular function and dysfunction that occur on a systemic level (Holowatz et al, 2008;IJzerman et al, 2003).…”

Section: In Vitro Vascular Modelsmentioning

confidence: 99%

Transdermal iontophoresis as an in-vivo technique for studying microvascular physiology

Tesselaar

Sjöberg

2011

Microvascular Research

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Section: In Vitro Vascular Modelsmentioning

confidence: 99%

Transdermal iontophoresis as an in-vivo technique for studying microvascular physiology

Tesselaar

Sjöberg

2011

Microvascular Research

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“…The role of impaired microvascular haemodynamics is increasingly being recognised in the pathogenesis of sub-sequent vascular target organ damage [7,8]. This may, in part, represent shared risk factors; however, the association remains when these are adjusted for, indicating that microvascular injury may occur on the mechanistic pathway between risk factors and vascular target organ damage.…”

Section: Introductionmentioning

confidence: 99%

Differences in the association between type 2 diabetes and impaired microvascular function among Europeans and African Caribbeans

et al. 2005

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Aims/hypothesis: Diabetes is associated with microvascular damage in all populations, but diabetic patients of Black African descent (African Caribbeans) have a greater risk of vascular target organ damage than would be anticipated for any given blood pressure level. We investigated whether this may be due to differences in the microvasculature. Materials and methods: To assess the maximum hyperaemic response to heating and the post-ischaemic response, Laser Doppler fluximetry was performed on 51 and 100 Europeans, and on 66 and 88 African Caribbeans with and without diabetes, respectively. Subjects were aged between 40 and 65 years and recruited from the general population. Echocardiographic interventricular septal thickness (IVST) was measured as a proxy for vascular target organ damage. Results: In diabetic subjects of both ethnic groups, the maximum hyperaemic response and peak response to ischaemia were attenuated as compared to the corresponding non-diabetic subjects (p=0.08 for diabetic and 0.03 for non-diabetic Europeans; p=0.03 and 0.1 for African Caribbeans). Adjustment for cardiovascular risk factors, in particular insulin and blood pressure, abolished these differences in Europeans (p=0.8 for diabetic and 0.2 for non-diabetic Europeans), but not in African Caribbeans (p=0.03 and 0.05). Conclusions/interpretation: Persisting microvascular dysfunction in African Caribbeans may contribute to the increased risk of target organ damage observed in diabetes in this population. The weak contribution of conventional cardiovascular risk factors to these disturbances indicates that conventional therapeutic interventions may be less beneficial in these patients. There was a risk-factor-independent, inverse association between IVST and maximal hyperaemia. These ethnic differences in microvascular responses to temperature and arterial occlusion could account for increased target organ damage in African Caribbeans.

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“…A pele é facilmente acessível [1] e potencialmente representativa [2] para a avaliação dos mecanismos de função e disfunção da microcirculação periférica [3][4][5] em particular quando são usadas tecnologias não invasivas, como a Fluxometria por Laser Doppler (FLD). A FLD está entre as tecnologias mais amplamente utilizadas para este propósito [6] , fornecendo um sinal complexo que pode ser decomposto em componentes com intervalos de frequência característicos, por meio de ferramentas de análise espectrais, tais como a transformada rápida de Fourier, a modelação autorregressiva e a análise de ôndula [7] .…”

Section: Introductionunclassified

“…The skin is easily accessible [1] and potentially representative [2] for the evaluation of peripheral microcirculation function and dysfunction mechanisms [3][4][5] , in particular when noninvasive technologies such as Laser Doppler Flowmetry (LDF) are used. LDF is among the most widely employed technologies for this purpose [6] , providing a complex signal which can be decomposed into components with characteristic frequency ranges by means of spectral analysis tools, such as the fast Fourier transform, autoregressive modelling and wavelet analysis [7] .…”

Section: Introductionmentioning

confidence: 99%

The wavelet transform as a tool for the characterization of the vascular response in the human lower limb

Silva¹,

Ferreira²,

Buján³

et al. 2014

BBR

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75 Biomedical and Biopharmaceutical Research J o r n a l d e I n v e s t i g a ç ã o B i o m é d i c a e B i o f a r m a c ê u t i c aThe wavelet transform as a tool for the characterization of the vascular response in the human lower limb AbstractIn recent years, cutaneous microcirculation gained considerable interest for the assessment of microcirculation function and dysfunction mechanisms. Laser Doppler Flowmetry (LDF) is a noninvasive and widely employed technology to study microcirculation. It provides a complex signal that may be decomposed by wavelet analysis into several components at characteristic frequency ranges. These are related to the heart (0.6 Hz to 2 Hz), respiration (0.15 Hz to 0.6 Hz), myogenic activity in the vessel wall (0.052 Hz to 0.15 Hz), sympathetic activity (0.021 Hz to 0.052 Hz) and endothelial (nitric oxide-mediated) activity (0.0095 Hz to 0.021 Hz). A group of 30 healthy (22.3 ± 3.1) years old subjects , giving previously informed consent, tested two perfusion-restricting protocols which allowed us to study the circulatory response in the lower limb: (1) passive leg elevation from the supine position for 10 minutes, (2) inflated cuff occlusion at the ankle level for 3 minutes from the sitting position. The LDF signal was partitioned using a Morlet wavelet model. Data analysis revealed significantly lower components' amplitudes for both protocols during provocation, with consistently lower values for protocol 1 in relation to protocol 2. Significant gender differences were found for protocol 1 but not for protocol 2. These results demonstrate the usefulness of the wavelet analysis to assess each LDF signal component as part of the physiological response to the lower limb microcirculation regulation.

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Individuals at increased coronary heart disease risk are characterized by an impaired microvascular function in skin

Abstract: Increased CHD risk is associated with an impaired endothelium-dependent vasodilatation and capillary recruitment in skin, suggesting that microvascular function in skin is a valid model to study the relationships between cardiovascular risk factors and microvascular function.

Cited by 235 publications

References 46 publications

Transdermal iontophoresis as an in-vivo technique for studying microvascular physiology

Transdermal iontophoresis as an in-vivo technique for studying microvascular physiology

Differences in the association between type 2 diabetes and impaired microvascular function among Europeans and African Caribbeans

The wavelet transform as a tool for the characterization of the vascular response in the human lower limb

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