Individualizing the risk for preterm birth: an overview of the literature

Os, Melanie van; Ven, Jeanine van der; Kazemier, Brenda M.; Haak, Monique; Pajkrt, Eva; Mol, Ben Willem J.; Groot, Christianne de

doi:10.1586/17474108.2013.825481

Cited by 5 publications

(2 citation statements)

References 65 publications

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“…Etiology of preterm labor may be vascular disease, and breakdown in maternal-fetal tolerance, uterine over distension, maternal stress, cervical weakness (4-9); or infection. (10)(11)(12) Low socioeconomic status, poor antenatal care, extremes of maternal age and malnutrition, low maternal pre-pregnancy body mass index (19.8 kg / m2 or less), maternal smoking, substance abuse, alcohol consumption, heavy physical work, and a short pregnancy interval (less than 18 months between pregnancies), cervical issues, uterine malformation, prior history of preterm birth; are considered risk factors for preterm delivery (13)(14)(15). Acute phase reactants (APR) are inflammatory markers which show significant changes in serum concentration during inflammation.…”

Section: Introductionmentioning

confidence: 99%

The Role of Acute Phase Reactants (Fibrinogen, Ferritin, Albumin, Calcium) in Pregnant Women with Preterm Delivery

Ibrahim

Mosa

2022

JFacMedBagdad

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Background: Preterm labor and related prematurity are predisposing factors that increase perinatal morbidity and mortality. Acute phase reactants are inflammatory markers which are positive and negative reactants explained by the reaction of reactants to the subclinical infection that are commonly associated with preterm labor. Objectives: To assess the role of acute phase reactants in pregnant women with preterm delivery. Patients and method: A case control study conducted in Gynecological Department of Baghdad Teaching Hospital from 1st February 2021 to 30th October 2021, on one hundred pregnant women with gestational age (28weeks - 36weeks+6days) who attended outpatient clinic; fifty pregnant women with established preterm labor as case group and fifty pregnant women with no signs and symptoms of preterm labor as control group. Data was collected using structured questionnaire included demographic features, and biochemical parameters (serum ferritin (ng/ml), albumin (gm/dl), fibrinogen (mg/dl), and calcium (mg/dl) . Results: Mean±SD serum ferritin in control group was (46.2 ± 16.2 ng/ml) while in case group (52.47 ± 11.6ng/ml) with significant difference between both groups (P=0.03), mean±SD serum albumin in control group (3.18 ± 0.31 ng/ml) while in case group (2.92 ± 0.39) with highly significant difference between both groups (P<0.001). Validity test of serum ferritin at cutoff ≥ 52.7 (ng/ml) in case group was as follows: Sensitivity (94%), specificity (90%), negative predictive value (94%), positive predictive value (90%) and the accuracy was (92%). The validity test of serum albumin at cutoff ≤ 3.06 (gm/dl) to detect the preterm labor as follows: Sensitivity (78%), specificity (86%), negative predictive value (78%), positive predictive value (83%) and the accuracy was (84%). Mean±SD serum fibrinogen in control group was (400.9 ± 38.1) while in case group was (410.7 ± 51.2) with no significant difference between both groups (P=0.1). Mean±SD serum calcium in control group was (8.1 ± 0.7) while in case group was (7.92 ± 0.5) with no significant difference between both groups (P=0.1). Conclusion: serum ferritin and albumin can be used in prediction of preterm labor in 3rd trimester.

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Section: Introductionmentioning

confidence: 99%

The Role of Acute Phase Reactants (Fibrinogen, Ferritin, Albumin, Calcium) in Pregnant Women with Preterm Delivery

Ibrahim

Mosa

2022

JFacMedBagdad

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“…El parto pretérmino es una de las causas más importantes de morbimortalidad perinatal en el mundo (6) ; ha aumentado en las últimas décadas y los ginecoobstetras tienen un rol relevante en disminuir dicha morbimortalidad (7) . Se señala que los indicadores de riesgo de parto pretérmino espontáneo pueden ser categorizados en cinco grupos: características individuales de la madre (etnicidad/raza), características del feto (género, número y corionicidad fetal), historia obstétrica (de parto pretérmino), indicadores de riesgo modificables (estatus social, estilo de vida, infección) y los signos en sí de parto prematuro; y son predictores potenciales los marcadores ecográficos y los biomarcadores (6) . El artículo Medición de la longitud del cérvix por ecografía abdominal en gestantes normales entre 21 a 23 semanas evalúa la factibilidad técnica de medir la longitud del cérvix por ecografía abdominal en gestantes entre 20 y 23 semanas, de manera de disminuir los riesgos de la ecografía transvaginal en estos casos.…”

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Romero

2015

Rev peru ginecol obstet.

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Hace pocos días, Medscape publicó un resumen de los avances en el tratamiento de la infertilidad, al recordar que hace 62 años nació el primer bebé concebido utilizando esperma congelado(1). Desde entonces, se ha ideado una creciente variedad de opciones para aumentar las posibilidades de concebir, desde la fertilización in vitro (FIV) a la congelación de tejido ovárico y el trasplante de útero. El primer bebé por fecundación in vitro (FIV), Louise Joy Brown, nació en 1978, y desde entonces millones de padres han tenido descendencia mediante este procedimiento. Otra técnica, desarrollada en los inicios de los 1990s, es la inyección intracitoplasmática de espermatozoides (ICSI), utilizada inicialmente para problemas de infertilidad masculina. Se ha obtenido la fertilización hasta en 50% a 80% de las veces, pero, en comparación con la FIV convencional, su uso no parece haberse asociado con mejores resultados reproductivos, según el artículo de Medscape.

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Routine second trimester cervical length screening in low risk women identified women at risk of a ‘very’ preterm birth but did not reduce the preterm birth rate: a randomised study from India

Mishra

Bagga

Kalra

et al. 2018

Journal of Obstetrics and Gynaecology

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Women (n = 300) at 'low risk' for a preterm birth (PTB), a singleton pregnancy and for a 16-24 week period of gestation (POG) were randomised to undergo cervical length (CL) measurement by transvaginal sonography (TVS) or not. The aim was to see if routine CL measurement and treatment of a short CL reduced the PTB rate. 'Low risk' was defined by an absence of a prior abortion or PTB of a singleton infant (>16 to <37 weeks) due to a spontaneous preterm labour (PTL) or a preterm pre-labour rupture of membranes (pPROM). The PTB rate was similar in the screened and unscreened group (10.3 and 8%, respectively, p = .433). In the screened group, women who delivered at 'term' or 'moderate to late' preterm (32 to <37 weeks) had a significantly higher mean CL (3.46 ± 0.41 and 3.48 ± 0.65 cm, respectively) than the women who delivered 'very' preterm (28 to 31 + 6 weeks; 2.05 ± 0.5 cm; p = .01). A short CL ≤2.5 cm was observed in two primigravidas (2/147 or 1.3%). They delivered at 28 + 3 and 30 + 6 weeks POG, respectively, despite treatment with vaginal progesterone and rescue cerclage in one. Their neonates were discharged in a good condition. In our low risk cohort, a routine second trimester CL measurement did not reduce the overall PTB rate. However, it identified two primigravidas at risk of having a 'very' PTB.Clinical Trials Registry (CTRI), India: Registration number CTRI/2016/01/010438 Impact statement What is already known on this subject? In women with a singleton pregnancy who are at a 'low risk' for preterm birth (PTB), a short cervical length (CL) at mid trimester measured by transvaginal sonography (TVS) identifies those at risk for a PTB. This risk may be reduced by the treatment with vaginal progesterone. At present, though evidence in favour of CL measurement in low-risk women exists, it is not established as a part of antenatal care. What do the results of this study add? A routine second trimester CL measurement in low risk women did not reduce the PTB rate. However, screening for a short CL helped to identify two primigravidas at risk for a 'very' PTB. It may be possible that detection and treatment of a short CL averted an 'extremely' PTB (<28 weeks) in these two women. What are the implications of these findings for clinical practice and/or further research? Future studies should assess the outcome of women with a short mid-trimester CL to see whether its treatment resulted in pregnancy prolongation and an improved neonatal outcome.

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Individualizing the risk for preterm birth: an overview of the literature

Cited by 5 publications

References 65 publications

The Role of Acute Phase Reactants (Fibrinogen, Ferritin, Albumin, Calcium) in Pregnant Women with Preterm Delivery

The Role of Acute Phase Reactants (Fibrinogen, Ferritin, Albumin, Calcium) in Pregnant Women with Preterm Delivery

Editorial

Routine second trimester cervical length screening in low risk women identified women at risk of a ‘very’ preterm birth but did not reduce the preterm birth rate: a randomised study from India

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