Individualized Running Wheel System with a Dynamically Adjustable Exercise Area and Speed for Rats Following Ischemic Stroke

Wang, Yu Lin; Cheng, Jui Chi; Chang, Ching‐Ping; Su, Fong-Chin; Chen, Chi Chun

doi:10.12659/msm.924411

Cited by 3 publications

(2 citation statements)

References 37 publications

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“…That design does not allow for a tether or unobstructed video recording, but does incorporate positional tracking using infrared sensors. There, position alone is used to grade exercise and to enable a more limited responsive exercise approach 26 . In general, the construction and hardware configuration are much more complex than our design, and do not allow for measurements other than position.…”

Section: Discussionmentioning

confidence: 99%

Adaptive Wheel Exercise for Mouse Models of Parkinson’s Disease

Skelton,

Grogan,

Kotlure

et al. 2024

Preprint

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Exercise is widely studied as a therapy in mouse models of neurological disease. However, the established techniques for exercise in mice are not ideally suited toward motor deficient disease models, nor do they facilitate active measurement of neurophysiology with tethered assays. To address this, we developed an apparatus and technique for inducing exercise in mice without aversive stimuli, using a motorized wheel with closed-loop acceleration that tracks subject performance. We demonstrated the efficacy of this approach in the 6-hydroxydopamine mouse model of PD, including with single-unit electrophysiology. This approach should allow for exercise to be better studied as a dynamic, physiological intervention in neurological disease models.

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Section: Discussionmentioning

confidence: 99%

Adaptive Wheel Exercise for Mouse Models of Parkinson’s Disease

Skelton,

Grogan,

Kotlure

et al. 2024

Preprint

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“…For many biological and medical studies, it is necessary to assess the movements of laboratory animals. As an example, some studies require the animal to run involuntarily on a treadmill or motorized wheel [1][2][3][4]. In Alzheimer treatment strategies, exercise plays an important role [5], and forcing a laboratory animal to run involuntarily is imperative.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2024

INTERNATIONAL JOURNAL OF INNOVATIVE RESEARCH IN ELECTRICAL, ELE

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Stepper motors are the most commonly used motors for all devices that require precise displacement or movement. Among these devices, motorized wheels and treadmills are designed for small laboratory animals and their speed requires adjustment in revolution per minute (RPM) mode. In this study, an Arduino code is introduced to control a stepper motor speed in RPM mode. This software has the ability to set the speed of the motor between 1 and 30 RPM. Additionally, an Android application has been developed for controlling the rotational time of stepper motors. In current study, all codes and Arduino-based circuits were evaluated using a homemade motorized wheel for rat and mice.

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